摘要:

Two cases of epidermoid carcinomain situof the skin, one with mucinous metaplasia and the other with sebaceous metaplasia, are reported. These unique cases suggest a spectrum of differentiation possible by neoplastic epidermal keratinocytes, which may help in the understanding of the histogenesis of certain skin neoplasms.

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1981.tb00990.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Misonidazole, a hypoxic cell radiation‐sensitizer, has been usedin vivoto analyze its effects on normal and x‐radiation epidermis. The drug action was evaluated 3 days after being implanted subcutaneously. The response of the epidermis and especially of the basal cells to the drug alone and in combination with x‐radiation was studied. The ultramorphological analysis as well as quantitative data on epidermal thickness and keratinocyte volume showed that high doses of misonidazole impair the usual post‐irradiation epidermal reaction, thus enhancing the involutional effects of radiation and inhibiting radiation‐damage repair, even under conditions of normal ox

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1981.tb00991.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Supernumerary nipple (SNN) is a developmental abnormality that occurs most commonly over the anterior aspect of the trunk in the pathway of the embryonic milk lines. This report describes a histologic study of 48 eases with 51 SNN found among 360,000 consecutive skin biopsy specimens received in a dermatopathology laboratory. Histologically, the supernumerary nipple shows all the components observed in the nipple area, including epidermal thickening, pilosebaceous structures, smooth muscles and mammary glands. A brief review of the literature is also made concerning the incidence and other characteristics of this lesion.

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1981.tb00992.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Twenty patients with rheumatoid arthritis (RA) had a biopsy taken from clinically normal skin. These were examined for histological and immunological abnormalities and were compared to those of 8 patients with osteoarthritis (OA). No ‘lupus band’ linear deposition of immunoglobulin or complement at the dermo‐epidermal interface was seen in any patient in either group. Perivascular deposits were seen in 5 out of 20 (25%) patients with RA. These were of IgM in all 5 cases with additional C, in 2 cases (10%) and additional fibrin in one case (5%). No immunoprotein deposits were seen in specimens from any OA patient. 4 of the 5 patients with perivascular immunoprotein deposits had circulating ANAs present and dilutions of 1/256 or higher but normal DNA binding. A sparse perivascular, predominantly lymphoeytie infiltrate was seen in 13 out of 20 (65%) patients with RA and 3 of 8 (35%) patients wi

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1981.tb00993.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

A skin biopsy from an 8‐year‐old boy with generalized lichen nitidus revealed a transepidermal perforating lesion never observed before in this disorder. A disturbance in dermo‐epidermal interaction with alterations of epidermal cell kinetics could explain this finding in a disease which, curiously, shows many histologic features conducive to transepidermal perforation. A clear distinction should be made between primary and secondary perforating dermatoses, since perforation per sc is a non‐specific cutaneous reaction pattern occurring in the course of many unrelated di

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1981.tb00994.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1981.tb00995.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1981.tb00996.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY