摘要:

Sixty‐nine patients with predominantly asymplomatic solitary angiomatous lesions were studied. Lips and perioral skin were the usual location, and the lesion occurred almost exclusively in adults. The essential histopathologic features are multiple dilated vascular channels located in the corium or submucosa and without significant epidermal participation. Anastomosing vascular spaces are lined by endothelial cells and thin‐walled veins contrast sharply with arteries showing thick fibromuscular walls. The pathogenesis of these peculiar hemangiomas is unknown, but they probably represent hamartomas with numerous arteriovenous shunts and arise from the subpapillary vascular plexus. Simple surgical excision is curative and represents the treatment of choice. The term of arteriovenous hemangioma is proposed for this clinicopathologic entity and should be considered in the differential diagnosis of other acquired benign hemangiomas and vascular lesions occurring in middle‐aged pat

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1974.tb00195.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

The pathogenetic mechanisms in acanthosis nigricans are not well known. Hirschowitz et al. (1971) described a new syndrome which included complete nerve deafness, progressive peripheral sensory nerve demyelinization, loss of gastric antral motility, multiple diverticula of ileum and lower jejunum, steatorrhea and unusually extensive acanthosis nigricans. Dramatic clinical and histological response of the dermatosis to topical vitamin A acid treatment led to search and demonstration of severe hypovitaminosis A. The trifluoroaceticacid method ofNeeld&Pearson (1963), repeatedly used with serum samples, either failed to detect β‐carotene and/or vitamin A or showed levels below the normal range. These findings indicate that vitamin A deficiency may be a factor in the pathogenesis of acanthosis nigrica

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1974.tb00196.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

Two cases are reported, one of multiple myeloma and the other of erythrodermia (malignant reticulosis?), the former associated with a Bence‐Jones paraprotein and the latter with IgM paraproteinemia. With anin vitroculture technique and/or the immunofluorescence method it could be demonstrated that the paraprotein present in the serum was synthesized not only in the bone marrow but also in the lesional ski

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1974.tb00197.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

The activities of five enzymes of carbohydrate metabolism were determined by fluorometric micromethods in epidermal tumors (basal and squamous cell epithelioma, keratoacanthoma, verruca seborreica) and compared to the activities in the adjoining, apparently normal epidermis. Glutamic pyruvate transaminase activity was reduced in all cases: that of the other enzymes was generally increased, except for isocitrate dehydrogenase and glutamic‐aspartate transaminase in squamous cell epithelioma

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1974.tb00198.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1974.tb00199.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1974.tb00200.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY