摘要:

We examined 32 cases (38 lesions) of extramammary Paget's disease (EMPD) in relation to comparative studies on intraductal carcinoma of the breast (ductal carcinoma in situ, DCIS) and apocrine adenocarcinoma (AAC). Lesions included scrotum (18 lesions), vulva (8), axilla (6), groin (3), penis (2) and chest wall (1), and the distribution was compatible with that of apocrine or supernumerary mammary glands. Histologically, extra‐mammary Paget's and DCIS cells exhibited a large amount of a pale‐stained cytoplasm. The cytoplasm of AAC cells frequently contained granules, was eosinophilic and differed from that of Paget's or DCIS cells. Immunohistochemical studies revealed positive reactions for polyclonal and monoclonal antibodies to carcinoembryonic antigen in all EMPD and most DCIS, but not in AAC. Recent studies have shown that extramammary Paget's cells exhibit characteristics of glandular epithelial cells and that most cases of EMPD are not accompanied by an underlying carcinoma. The results obtained in this study, coupled with data on the frequency of the supernumerary breasts, lead to the speculation that extramammary Paget's cells originate from ectopic mammary glands or from pluripotential germinative cells in the epidermis, capable of differentiating toward the mammary gla

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1990.tb00099.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

The incidence of pericapillary fibrin cuffs was investigated in 49 biopsies of venous leg ulcers and 67 biopsies of leg ulcers of non‐venous etiology. Pericapillary fibrin cuffs were seen in 28 biopsies (57.1%) of venous leg ulcers, but only in 11 biopsies (16.4%) of non‐venous leg ulcers. In the venous leg ulcers pericapillary fibrin cuffs occurred predominantly near the ulcer surface and around dilated capillaries. Dilation of the capillaries and inflammation probably contribute more to the pathogenesis of pericapillary fibrin cuffs than venous hypertens

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1990.tb00100.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

A 63‐year‐old Chinese man with a solitary sclerotic fibroma on the abdomen is described. Skin biopsy showed a well‐demarcated dermal nodule composed of hypocellular, eosinophilic collagen bundles separated by prominent clefts. Retrospective electron microscopic study revealed wide collagen bundles containing tightly packed collagen fibrils, only 50 nm in diameter. There were no signs of Cowden's disease. To our knowledge, this is the first report of electron microscopic study of sclerotic fibroma. A brief review of the literature is inc

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1990.tb00101.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

We report a case of cutaneous metastases from a scapular chondrosarcoma in a 85‐year‐old man. The metastatic skin lesion was noted nine years after resection of the primary tumor. Metastases to lung and soft tissues had occurred four years earlier. The patient also had a history of malignant melanoma. Although this case illustrates an unusual pattern of metastases, we conclude that the appearance of cutaneous lesions in a patient with a prior history of chondrosarcoma should alert the clinician to the possibility of a metastatic chondrosarc

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1990.tb00102.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

We report an angioleiomyoma developed within a cellular histiocytoma on the calf of a 77‐year‐old man. The lesion consisted of a spherical nodule with two well‐defined concentric areas. The outer circular area was a cellular histiocytoma and the inner central area consisted of an angioleiomyoma. Immunoperoxidase investigations for desmin demonstrated positivity in the angioleiomyoma, whereas the histiocytoma positivity in the angioleiomyoma, whereas the histiocytoma remained negative. Serial sections of the lesion failed to demonstrate a connection between the angioleiomyoma and a normal vein which could have been trapped by the histiocytoma. The angioleiomyoma may have originated from a vessel in the histioc

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1990.tb00103.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1990.tb00104.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1990.tb00105.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1990.tb00106.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY