摘要:

Schwann cell features were found on ultrastructural examination of a neurotropic melanoma (de novotype) of the lip. A neurotropic pattern of growth was retained in metastatic tumors in lymph nodes and lung. Melanin was not demonstrable in extra‐epidermal tumor cell

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1981.tb00997.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

The following features of trichoepithelioma papulosum multiplex (TPM) were revealed by electron microscopy: 1. Proliferation of basaloid cells similar to that in basal cell epithelioma (BCE). 2. Abortive hair shafts and hair papillae. 3. Keratinous cysts surrounded by flat keratinocytes, the cytoplasm of which had small‐sized keratohyalin and Odland's bodies. 4. Glycogen deposition near the nuclei, vacuoles filled with amorphous materials and lipid droplets in the cytoplasm of tumor cells. 5. Extracellular compartments, in which fibrous materials, cell fragments, and mucinous substance were found. 6. Melanocytes containing melanosomes in stage 11, Langerhans cells involving Birbeck's granules, Merkel cells and other dendritic cell

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1981.tb00998.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

An electron microscopic study was performed to demonstrate the pathological changes induced by long term PUVA treatment in recalcitrant psoriasis. Three patients developed mottling (hyperpigmentation and hypopigmentation) during two to three years of treatment. Three different types of morphological changes were found: disarrangement of keratinocytes, clustering and stimulation of melanocytes and homogenization of papillary dermis. Furthermore, the superficial blood vessels were loaded with the same type of amorphous granular substance. These changes might be specific to PUVA treatment or they might occur only in patients with previous treatment with, e.g., arsenic, methotrexate, anthralin + UVB or a combination of these.

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1981.tb00999.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

An ointment containing 0.05% retinoic acid (RA) was applied to the anterior surface of the chest in a patient suffering from Darier's keratosis follicularis. A mixture of two ointments containing equal amounts of 5% 5‐fluorouracil (5‐FU) and 0.05% RA was used on the dorsum of the same patient. Biopsies were taken 30 days and 70 days after treatment started. Retinoic acid gave rise to an initial disorganisation of desmosomes; the “corps ronds” and “grains” disappeared, the lacunae gradually decreased in size, and the epidermis was practically normal when the clinical manifestations of the skin had disappeared. The damage induced with the RA + 5‐FU mixture was more serious, but when the skin lesions relapsed they did so later and in a less severe way than the recurrences observed after treatment

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1981.tb01000.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Two cases of juvenile elastoma (nevus elasticus in disseminated tumors) were histologically and ultrastructurally investigated. The predominant components of this disseminated dysembryoplasia are abnormal elastic fibers. Both cases showed numerous large elastic fibers with an abundant background matrix. The elastic microfibrils were replaced by granular material. In one case, most of the abnormal elastic units remained isolated without forming elastic fibers.

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1981.tb01001.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

This report describes thein situdemonstration of “T” lymphocytes and “T” lymphocyte subsets in tissue sections using a case of lichen planus as a model. The technique utilized is the indirect immunoperoxidase method with monoclonal antibodies to “T” cells and “T” cell subsets. In the case examined a predominance of helper “T” cells was found. The potential application of this method in the immunopathology of skin and internal

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1981.tb01002.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Although basal cell carcinomas are the commonest malignant condition of the skin (Borel 1973) pulmonary metastases are rare; it appears that only 30 authenticated cases have been reported (Sakula 1977). A futher case is described of a man aged 64 who presented with severe dyspnoea and who for 12 years had harbored an untreated ulcerating lesion of the abdominal wall shown histologically to be a basal cell carcinoma. Chest radiography showed metastatic disease confirmed histologically to be identical to the ulcerating skin lesion. Unfortunately, because of the severe respiratory condition, no definitive treatment was indicated and the patient died of respiratory failure 2 weeks following discharge.

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1981.tb01003.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

A carcinosarcoma of the skin in a 74–year‐old man is reported. The epithelial clement consisted of a highly anaplastic basal cell carcinoma with focal keratinization. The mesenchymal component included elements of fibrosarcoma, chondrosarcoma, osteogenic sarcoma, and synovial sarcoma. This is, to our knowledge, the second reported case of carcinosarcoma arising in the s

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1981.tb01004.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Two children with unusual milia‐Iike lesions on the pubic and groin area were found to have idiopathic perforating calcinosis cutis. The inconspicuous clinical appearance may escape detection unless a biopsy is performe

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1981.tb01005.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

A 35‐year‐old woman was examined because of a symptomless multiple annular eruption. The lesion consisted of rings of closely set, smooth, firm papules that were brown in color. Hemosiderotic histiocytoma was diagnosed by light and electron microscopy. Ultrastructurally, the lesion consisted of fibroblastic and histiocytic cells with marked hemosiderin and lipid deposit

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1981.tb01006.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY