摘要:

Histological, histochemical and immunohistochemical findings were studied in 40 cutaneous biopsies from 7 patients with Cowden's disease. Most facial biopsies showed a spectrum of trichilemmomas and related follicular malformations, including cylindrical trichilemmomas, lobulate trichilemmomas (14 lesions), and a keratinizing type sharing features with inverted follicular keratosis. One facial growth showed trichilemmomal changes without apparent follicular origin. Studies for common papilloma virus structural antigens were negative, apart from a typical common wart in one patient. Immunohistochemical studies in 6 facial trichilemmomas and acral keratoses, using a panel of anti‐keratin antibodies, disclosed only abnormal differentiation with lack of large keratins in the lobulate trichilemmomas. Nine biopsies revealed a distinctive type of fibroma characterized by an organized pattern of interwoven fascicles of collagen bundles with a laminated or tortuous appearance, embedded in abundant mucin. A number of fibromas showed striking hyalinizalion; these may represent a second microscopic hallmark of Cowden's disease in addition to facial trichilemmoma

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1985.tb01607.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

The literature about the changes occurring in histiocytomas mentions only the possibility of induction of primitive pilosebaceous structures and basal cell epithelioma‐like lesions by the histiofibrocytic growth. We suggest here that the histopathologic findings arc indicative of regressive changes of the pre‐existing cutaneous adnexa resulting in the formation of basal cell epithelioma‐like struc

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1985.tb01608.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

A 78‐year‐old woman with a history of follicular carcinoma of the thyroid developed a painless nodule on her face. A skin biopsy showed a dermal tumor composed of cells with granular, cosinophilic cytoplasm. Immunoperoxidase staining demonstrated thyroglobulin in the tumor cells, confirming the diagnosis of meta‐static thyroid carc

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1985.tb01609.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

Apocrine hidrocystomas are often pigmented clinically. The cause of this pigmentation is not known. A case of pigmented apocrine hidrocystoma is presented with evidence of melanin as the underlying mechanism of the pigmentation. Review of an additional 150 cases suggests that this is rare. The Tyndall effect, analogous to that seen in blue dome cysts of fibrocystic disease of the breast may be the likely explanation of the pigmentation seen clinically in most cases of apocrine hidrocystomas.

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1985.tb01610.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

Elastic fibers were found in the amyloid islands of primary systemic amyloidosis heredo‐familial amyloid polyneuropathy, macular amyloidosis andamyloidosis cutis nadularis atraphicans.In macular amyloidosis, the elaunin fibers in amyloid islands were loosely arranged, waved and twisted. In systemic amyloidosis and arm.loidosis cutis nodularis atrophicans, amyloid fibers did not deposit in homogeneous electron‐lucent material of elastic fiber, but were located close to the elastic fiber where the peripheral microfibrils were pres

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1985.tb01611.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

Recent investigations have suggested that in addition to basaloid cells, basal cell carcinomas (BCC) may also contain Langerhans cells and neuroendocrine cells. In order to establish the relative frequency of neuroendocrine differentiation in BCC, we performed a retrospective study of 50 consecutive BCC using conventional histochemical, immunocytochemical and ultrastructural methods. Argyrophil staining according lo Grimelius was used for initial identification. Tumors containing argyrophil cells, as well as randomly selected tumors without these cells, were immunocytochemically stained with a panel of antisera against neurohormonal pep‐tides. Only 2 tumors with argyrophil cells showed occasional somatostatin immunoreactivity; peptide hormone immunoreactivity could not be detected in any of the others. The somatostatin immunoreactive tumors, as well as 3 others, were subjected to electronmicroscopy to study the presence of dense‐core secretory granules. However, these characteristic intracytoplasmatic structures could be detected in none. It is concluded that if neuroendocrine differentiation exists at all in BCC, it must be extremely rare. Our results indicate that reliable identification of multiple lines of differentiation in neoplasms can only be performed using combinations of (immuno) histochemical and ultrastructural techniq

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1985.tb01612.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

Epidermal keratinocytes with abnormally large nuclei were found in 12 of 13 patients who received high‐dose busulfan and cyclophosphamide prior to receiving bone‐marrow transplantation for treatment of hematological malignancies. These cells were similar to those previously described in the lungs, cervix and bladder of patients on long‐term busulfan therapy. Marked keratinoeyte nuclear abnormalities were not observed in bone‐marrow transplant recipients who received a preparatory regimen of cyclophosphumide and total‐body irradiation. This histologic cutaneous busulfan effect was transient and was unrelated to the development of graft ‐versus‐

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1985.tb01613.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

A black baby, born al full term of a normal healthy mother, showed multiple erosions and ulcers. No history of skin diseases was known in the family. A skin biopsy taken shortly after birth from an arm lesion showed subepidermal edema and cavity formation. Electron microscopy showed clumping of microfibrils and anchoring fibril‐like fibers at the dermo‐epidermal junction. In more severely affected areas, absence of anchoring fibrils and collagenolysis were found and the diagnosis of dystrophic epidermolysis bullosa was made. Two weeks later, the lesions healed without leaving scars and a second biopsy from the chest area revealed typical histopathology of epidermolytic hyperkerato

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1985.tb01614.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

Thirty‐seven lesions from 29 patients withcondylomata acuminatawere comparatively studied by peroxidse‐antiperoxidase (PAP) technique and routine histopathology. PAP staining demonstrated pupillomavirus common antigen (PCA) mostly in the granular layer of the epidermis in 22 of 37 lesions (59%) ofcondylomata acuininata.Presence of PCA is closely correlated with the following histopathologic findings: 1) coarse keratohyalin granules; 2) perirmclear vacuolization or koilocytotic cells in the granular layer; 3) hypcrkeratosis with focal parakcratosis. From these findings it is concluded that these histopathologic findings suggest the presence of PCA, and that the presence of papillomavirus may play a role in the formation of these histopathologic features ofcondylomata acumin

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1985.tb01615.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

Serum amyloid P component (SAP) is present not only in all types of cutaneous amyloidosis, but also in the normal dermal clastic fibers as well as abnormal elastic‐fibers, such as clastotic degeneration of clastic fibers in actinic keratosis. It was previously postulated that the colloid substance in colloid milium is a final degeneration stage of actinic clastosis. In a lesion of colloid milium SAP was intensely positive with an indirect iinmuiiofluorescence method using rabbit antiserum to human SAP. Electron microscopy of the colloid lesion revealed components of normal elastic fibers as well as those of actinic elastoid as seen in actinic clastosis. It is concluded that the colloid substance derives, at least in major part, from elastic fibers through actinic degeneratio

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1985.tb01616.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY