摘要:

Multiple follicular tumors of the type recently described by Birt and colleagues as fibrofolliculomas were observed in the dorsal skin of a white man in association with a large connective tissue nevus. No signs of systemic disease or phakomatosis were present. This type of lesion represents benign neoplasia of the fibrous root sheath of the hair follicle in association with proliferations of the infundibular portion of the outer epithelial root sheath. Its existence supports the view that the mesodermal portions of the pilar apparatus can become neoplastic, and also provides another example of the close interactions existing between the ectodermal and mesodermal components of the hair follicle.

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1977.tb00920.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

Angiofibromas from two patients with tuberous sclerosis were studied by light and electron microscopy. Light microscopy revealed that these tumor‐like nodules (which in the past have been called adenoma sebaceum) were made up of dilated capillaries, venules and arterioles embedded in connective tissue. At the ultrastructural level the arterioles embedded in connective tissue. At the ultrastructural level the endothelium of these vessels showed large numbers of microvilli on their luminal surface. The stroma contained many banded structures (so‐called fibrous long spacing collagen). Myofibroblasts recently described in juvenile nasopharyngeal angiofibromas were not found in these angiofibromas of tuberous sclero

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1977.tb00921.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

A primary leiomyosarcoma of skin was studied by light and electron microscopy and by histochemistry. Systematic evaluation of the entire neoplasm suggested that a single biopsy sample would show little cellular pleomorphism but could vary considerably in number of mitoses per mm2. Electron microscopy revealed a high degree of cytologic differentiation. Strong myosin ATPase activity and negative demonstrations for hydrolytic enzymes suggest a diagnostic profile which will clearly separate this neoplasm from malignant fibrous histiocytoma. High mitoses counts, the conventional criterion for malignancy of non‐cutaneous smooth muscle tumors, may not be appropriately applied to primary leiomyosarcomas arising in the dermis. The findings in this case and a critical review of the literature suggest that reliable criteria for diagnosis of primary cutaneous leiomyosarcoma by light microscopy remain to be establishe

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1977.tb00922.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

Cutaneous papules of two patients with the Hunter syndrome (mucopolysaccharidosis II) were compared with their normal appearing skin by light and electron microscopic techniques. While most fibrocytes of normal and papular skin contained metachromatic cytoplasmic material and characteristic vacuoles, only the papules had extracellular accumulation of metachromatic material and evidence of coalescence and rupture of vacuoles. Alcohol fixation provides better preservation of the mucosubstances.

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1977.tb00923.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

Two collodion baby girls with disorder evolving into lamellar ichthyosis were followed by light and electron microscopy. Light microscopically, the neonatal collodion skin was characterized by a thick compact stratum corneum which was PAS positive in its upper two thirds, by a thin stratum granulosum and by a non‐acanthotic stratum spinosum with normal mitotic activity. Electron microscopically, the upper stratum corneum appeared pathological, whereas the lower part was normal except for some minor parakeratosis. The main alterations in the underlying stratum granulosum were diminished tonofibrils and keratohyalin. Biopsy specimens taken at the age of 2 weeks were typical for lamellar ichthyosis and showed hyperkeratosis with focal parakeratosis, a thickened stratum granulosum in which the cellular content of keratohyalin and tonofibrils was moderately diminished, and acanthosis with increased mitotic activity. It appears that the ultrastructural changes of the stratum granulosum, seen in lamellar ichthyosis, are already present in the collodion skin of the newborn, at a time when the epidermis does not yet show an increase in mitotic activit

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1977.tb00924.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

Punctate porokeratosis is not usually recognized as a clinical form of porokeratosis of Mibelli. Two cases of punctate porokeratosis are presented. Other punctate lesions with similar clinical features which should be considered in the differential diagnosis are discussed.

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1977.tb00925.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

Thirty‐nine keratoacanthomas from 35 patients have been studied, six of which showed perineural, and one vascular, invasion. Thus far, their aggressive histological behavior has not been paralleled by a similar clinical course. However, continued close follow‐up is essent

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1977.tb00926.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1977.tb00927.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1977.tb00928.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1977.tb00929.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY