摘要:

Antibodies prepared against the collagen C‐chain derived from human placenta specifically stain the epidermal basement membrane of normal human skin as well as the basement membrane surrounding the skin appendages and capillaries. Using the antibodies, it was observed that all basement membranes in untreated psoriatic plaques appear fragmented and separated into several layers. The results suggest that psoriatic lesions are associated with a general loss of basement membranc integrity which may play a crucial role in the pathogenesis of the diseas

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1979.tb01108.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

A report on four patients with psoriasis who have developed multiple keratoacanthomas and squamous cell carcinoma at the treatment sites is presented. Two other reports have appeared in the literature which link the development of keratoacanthoma with psoriasis and pustular psoriasis. Although a number of etiologic factors have been suspected for the development of these new growths, this presentation will further assess the specific roles that treatment measures may have played in these cases. Furthermore, the significance of impaired cellular immune defense mechanisms will be discussed.

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1979.tb01109.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Light microscopic examination of a basalioma (basal cell carcinoma) revealed unusual keratinizing cells resembling signet ring cells with pink cytoplasmic inclusions. Ultrastructurally the inclusions consisted of filamentous masses encircled by abundant tonofilaments giving a striking picture of abnormal individual tumor cell keratinization.

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1979.tb01110.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Twenty‐one of 65 (31%) biopsy specimens from patients with male pattern alopecia demonstrated the presence of individually displaced multinucleate giant cells without a significant concomitant cellular infiltrate. This finding was absent in a diverse group of other forms of alopecia. Whether individually displaced multinucleate cells are a useful histologic marker for diagnosingearly stagesof androgenetic alopecia remains to be determine

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1979.tb01111.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Two patients with solitary lesions of pagetoid reticulosis are presented. A third case with disseminated lesions and similar microscopic detail is also reported. Light microscopic findings include an abnormal cell infiltrate confined to the epidermis and distributed diffusely in a pagetoid pattern. In ultrathin sections, the abnormal cells are seen to have an abundant cytoplasm with numerous organelles and a convoluted nucleus, often with a prominent nucleolus. The nature of the abnormal cells is discussed. The infiltrate is differentiated from that of mycosis fungoides.

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1979.tb01112.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Janeway lesions in three patients with infective endocarditis caused byStaphylococcus aureuswere biopsied. Two, taken before therapy, showed evidence of suppuration and microabscesses. The other lesion which developed while the patient was on appropriate therapy, showed minimal inflammatory reaction.

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1979.tb01113.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Explants of skin from patients with pemphigus vulgaris and pemphigus foliaceus taken in the active stages of the disease hadin vivobound IgG in the intercellular area. After 24–48 h incubation of these explants in normal sera acantholytic bullae developed above the stratum basale, thus indicating that the bound IgG is probablyin vivobound pemphigus antibody. In both cases, skin from the inactive stage of the disease contained noin vivobound pemphigus antibodies. Explants of these skin specimens failed to develop acantholysis in cultur

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1979.tb01114.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

An 83‐year‐old man experienced abrupt onset of a solitary lesion of porokeratosis on his bald, actinically damaged scalp. The features in this case are unusual and represent another point in the broad spectrum of lesions characterized by the cornoid lamella of porokerato

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1979.tb01115.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

A patient with clinical and histologic features of epidermolysis bullosa dystrophica‐recessive (EBD‐R) developed superimposed clinical lesions of pityriasis rosea (PR). Electron microscopy showed distinct “blebbing” of basal cells at the basement membrane zone in clinically normal skin of a non‐predilected area, as well as in scarred skin from a predilected area and a lesion of PR. An increased susceptibility of the basement membrane zone to proteolytic enzymes is suggested as a possible hypothesis to explain these obs

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1979.tb01116.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1979.tb01117.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY