摘要:

Ultrastructural investigations in 15 patients with lichen planus (LP) revealed a multitude of epidermal changes. The most consistent findings were (1) multiplication, irregular folding or dislocation of the basal lamina, (2) fragmentation with degenerative changes of basal keratinocytes, (3) formation of numerous fibrillar Civatte bodies and, (4) presence of dyskeratotic elements. In addition, mitotic figures of keratinocytes and Langerhans cells were observed. These findings support the view that the primary event in LP represents an injury involving epidermal basal cells. Furthermore, the replacement of destroyed tissue seems to originate not only from the margin of the lesions or the skin appendages but also from unaffected cells within the LP papule.

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1976.tb00858.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Cell proliferation has been evaluated in four patients with discoid lupus erythematosus afterin vivoincorporation of tritiated thymidine. Numerous epidermal cells are in S phase or in mitosis. The acceleration of cell renewal is paralleled by a shortening of the transit time of completely differentiating keratinocytes. Remodellings of the vascular belt are evidenced by the labeling of many endothelial cells. There is no sign of lymphoblastic transformation in the dermis since the mononuclear infiltrate remains unlabeled.

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1976.tb00859.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

The eighth Colombian case of lobomycosis and the one hundredth in the world literature is reported here. The patient was a 38‐year‐old female who showed a bilobed mass on the left forearm which had appeared at the site from where a similar lesion had been excised 19 years previously. She had always lived in a rural area, located in the humid subtropical forest. The tissue reactions to the fungus as well as the fruitless attempts to culture it are described. An analysis of the relevant literature is made and suggestions for experimental animal models are given in the t

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1976.tb00860.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Two hundred moles were examined histologically and the degree and type of epidermal change was recorded and correlated with the arrangement, density and type of naevus cells present and with the clinical presentation. Resemblances to the epidermal architecture of seborrhoeic warts were noted in 49% of the moles studied (this type of change was mainly seen in younger patients). In these there was a predominance of epithelioid cells, mainly in the junctional and upper dermal zones. Thirty‐five per cent of moles possessed an epidermis with an overall appearance of being stretched, beneath which was a relatively clear zone followed by a uniform distribution of predominantly “lymphocytoid” naevus cells and large numbers of naevus cells of the giant type. These were found mainly in the older age groups. A third group (11%) was characterized by the presence of bulbous epidermal rete ridges and many junctional nests of naevus cells. This group was found mainly in younger age groups and there was often a history of recent change in the mole. It is concluded that the epidermal component of moles might itself be a naevoid disorder or result from the dermal disturbance induced by the mole

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1976.tb00861.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

A heretofore undescribed localization for solitary keratoacanthoma, namely the skin of the nipple, is reported. The tumor developed in a 69‐year‐old man who had suffered a trauma in the thorax near the left nipple 5 months before. A possible origin in mammary ducts, considering the breast as a modified sweat gland, is discus

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1976.tb00862.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

An ultrastructural investigation of two patients suffering from acrodermatitis chronica atrophicans revealed in the small dermal vessels swelling of the endothelial cells, material of probably plasmatic origin accumulated in the subendothelial area, and sleeves of basement membrane‐like material on a concentric perivascular layou

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1976.tb00863.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1976.tb00864.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY