摘要:

After radiotherapy and chemotherapy for treatment of a brain tumor, hyperpigmentation occured in a Caucasian man. Ultrastructural examination of the hyperpigmented skin revealed melanocytes often very prominent and extending down into the papillary dermis. These melanocytes seemed to be increased in number and contained large cytoplasmic lipidic vacuoles. Most striking was the prominent alteration in melanosome distribution within the keratinocytes. The melanosomes were mainly nonaggregated, as in negroids and were no longer arranged in membrane‐bound groups, as is usually found in Caucasian skin. Most melanosomes were completely melanized and their greatest length was 0.65 μ. An increase in the number of melanosomes was apparent. The present study shows that the basis for this hyperpigmentation is in part similar to that of UVL plus psoralen or topical application of nitrogen mustard, in that melanosomes in Caucasians remain un‐aggregated in the keratino

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1976.tb00872.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Two males with enlargement of one upper extremity, deep purple in color, and one female with a long, deep‐red stripe along the lower extremity were found to have an increased number of tiny vessels in the dermis with dense round‐cell infiltration consisting mainly of plasmacells. There were no signs of arteriovenous shunts, venous malformations or diseases associated with plasmacells. Polycythemia and thrombocythemia were excluded. Some immunological abnormalities were found in all cases. This condition seems to be self‐he

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1976.tb00873.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Biopsies taken from the lesions of cutaneous leishmaniasis of two patients showed, by light microscopy, abundant leishmania bodies within macrophages. Electron microscopic study showed leishmania parasites in various stages of degeneration within macrophages. In some macrophages a few Michaelis‐Gutmann bodies were seen in the cytoplasm; around them there was a positive Gomori reaction for acid phosphatase activity. This study confirms that Michaelis‐Gutmann bodies may develop from transformed phagosomes and demonstrates the heterogenicity of their ori

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1976.tb00874.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

When iodoxuridine (IDU) – carried in dimethylsulfoxide (DMSO) – was topically applied on penile lesions suspected to be herpes simplex, premalignant epidermal changes developed. Discontinuation of treatment resulted in complete healing. It seems wise when IDU in DMSO is used for similar cases, to consider this treatment experimental because both constituents of this preparation are, in theory, potentially carcinoge

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1976.tb00875.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

A case of nevus comedonicus is described which was bilateral, more prominent on the right side, worse on the buttocks with unusual verrucous nodules on the right helix, knee and elbows, and affecting the palms and soles. This patient would appear to have been the most seriously afflicted of the 130 reported cases. In addition to the more comedo‐like lesions on the trunk, a unique feature was the gradual development of verrucous nodules on the helix of the right ear, knee, hand and elbows. The pathologic changes on the nevus comedonicus on the trunk showed the epidermis to be invaginated, in some instances suggesting a tubular‐like quality, with a dilated orifice containing keratin protruding above the surface. Sebaceous glands and hair shaft were absent. The pathologic changes of the verrucous nodule could be described as a more severe form of nevus comedonicus with folding and involution of the epidermis forming large crypts and cysts filled with keratin. Lesions were generally more severe in areas of pressure, which might explain the production of verrucous nodu

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1976.tb00876.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

A peculiar branchiogenic malformation of the face producing a 2 × 1 cm excrescence on the left cheek of a 1‐month‐old girl is reported. The tumor was composed of normal skin with epidermal appendages and an axis with longitudinal and circular striated muscle fibers. There was also a mature cartilage nodule and cartilage and bone‐forming groups of cells. To the best of our knowledge, only one similar case has been previously re

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1976.tb00877.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1976.tb00878.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1976.tb00879.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1976.tb00880.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY