ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1988.tb00521.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Twelve cases of actinic graculoma (O'Brien) are reported. It is concluded that actinic granuloma is a specific disease characterized by clinical lesions indistinguishable from granuloma annulare, but occurring on solar damaged skin. Histologically, clastic tissue is destroyed by the granulomatous process in actinic granuloma. But not in granuloma annulare. It would appear that actinic granuloma, granuloma multiforme, necrobiosis lipoidica of the face and scalp (Wilson‐Jones) and Miescher's granuloma of the face (Mehregan and Altman) are the same deseas

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1988.tb00522.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

We have found a previously undescribed histopathologic feature of necrobiosis lipoidica diabeticorum among 310 biopsied cases: lymphoid nodules. This feature does not correlate with unique clinical lesions or forms of the disease. The lymphoid nodules are similar in appearance to those in other chronic dermal inflammations.

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1988.tb00523.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Electron micrographs of human mast cells in normal neonatal and adult skin and in cutaneous lesions of basal cell carcinoma (BCC), hemangioma and mastocytosis were assessed by morphometric analysis. Using this quantitative histologic approach, adult skin mast cells were found to be significantly larger (47.7μm2± 2.4 SEM vs. 38.3 μm2± 1.8 SEM, p<0.001) and have larger granules (0.63 μm ± .02 SEM vs. 0.53 μm ± .02 SEM, p 0.001) than infant mast cells while both mast cell populations had comparable nuclear sizes (13.7 μm2± 0.9 SEM vs. 14.3 μm2± 0.8 SEM) and numbers of cytoplasmic granules (72 ± 4.0 SEM vs. 66 ± 4.0 SEM). Morphometric analysis of mast cell infiltrates in the adult skin lesions of BCC and hemangioma revealed that these cells were larger than neonatal mast cells but were similar to normal adult controls. Cutaneous mast cells from 2 mastocytosis patients, however, had significantly larger mean cell surface areas (78.0 μm2± 3.4 SEM and 70.6 μm2+ 3.2 SEM, p<0.001), nuclear areas (20.8 μm2± 1.1 SEM and 21.3 μm2± 1.2 SEM, p 0.001) and granule diameters (0.82 urn ± 0.4 SEM and 0.83 μm ± .03 SEM, p ± 0.001) when compared with mast cells in normal adult skin and in the other pathologic lesions. No difference in the total number of cytoplasmic granules was observed in the different mast cell populations. This study demonstrates that morphometric analysis in combination with electron microscopy provides a valuable and sensitive tool for assessing mast cells in norma

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1988.tb00524.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

This study describes the presence of crystalline inclusions in the endothelial cells of foreskins. They were found in 9 normal full‐term newborn infants, without maternal medication or complication during pregnancy and delivery. These cytoplasmic crystalloids occurred in 10% of endothelial cells of small blood vessels. The diameter of the inclusions ranged from 0.3 to 1.5 μm and they appeared as round, oval, hexagonal or irregular polygonal in shape. These inclusions were surrounded by a triple membrane and their contents demonstrated granular, homogenous and crystalloid‐like material with a regular periodicity of dense and less dense layers measuring about 20–25 nm. Similar crystalloids in the endothelial cells were observed in the normal upper lip skin of a 6‐week‐old girl, although they were present in much smaller numbers than in foreskin. No endothelial inclusions were found in normal skin taken from 11 body areas in 29 patients aged 2.5 to 56 years. The nature and function of these cotyplasmic crystalloids a

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1988.tb00525.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

In two cases of elastosis perforans serpiginosa (EPS) new clinical and laboratory data are described and discussed. In Case 1, EPS was triggered by penicillamine‐D within an unusually short period (about one year). In Case 2, EPS was apparently primarily triggered by a vena puncture. In both cases the light and electron microscopic findings were strictly compatible with EPS. These findings are summarized. In the active lesions of botli cases increased numbers of helper T‐cells and Langerhans cells were shown, while cytotoxic‐suppressor T‐cells were nearly completely absent. Leu 3a+cells and Leu 6+cells were also present in the inactive central area of the lesions. The data presented may cast doubt on the relationship of immunological findings to pathogenetic events in the

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1988.tb00526.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Specimens from a patient with epidermolysis bullosa contained many elastic globes in the dermis. Ultrastructurally they were composed of (i) medium electron‐dense amorphous substances, (ii) electron‐dense round structures, and (iii) fine filaments. These various elements were seldom organized into typical normal elastic fiber and, therefore, it was difficult ultrastructurally to recognize them as such or components thereof. Immunohistochemically, elastic globes were strongly reactive with NKH‐1, which stains elastic microfibrils, and antibody to serum amyloid P component (anti‐SAP), which binds to elastic fiber micro‐fibrils. However, elastic globes were negative with EKH‐4 which recognizes 50 kd keratin of amyloid keratin and cytoid bodies. These findings suggested that elastic globes have a close immunologic profile to elastic fiber microfibrils, but not that of epidermal or epithel

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1988.tb00527.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Langerhans cells (LC) were identified and quantitated in non‐inflamed keratoacanthoma (KA), inflamed KA, non‐inflamed squamous cell carcinoma (SCC), and inflamed SCC, by their content of S100 protein. The number of LCs per high‐power field was markedly increased in inflamed KA when compared to the other groups. Using similar methods on frozen sections, the expression of HLA‐DR was identified on keratinocytes in KA in areas of inflammation but not in other lesions under study. We hypothesize that increased numbers of LCs in inflamed KA are part of the process which results in tumor reg

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1988.tb00528.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Rhabdomyosarcomatoid renal tumors were initially described as subset of tumors in the National Wilms Tumor Study that had light microscopic features similar to rhabdomyosarcomas. Subsequent studies failed to reveal evidence of muscle differentiation, thus the genesis of the term “rhabdoid” tumor. Such renal tumors are rapidly lethal. Recent reports suggest the occurrence of tumors with similar morphology in other anatomic sites. We wish to report primary malignant rhabdoid tumor of the facial skin with detailed immunohistochemical and Ultrastructural studies. Vimentin was expressed in the tumor cells, but there Was no immunoreactivity for cytokeratins, neurofilaments, muscle actin, synaptophysin, S‐100, melanoma antigen HMB‐45, epithelial membrane antigen, neuron specific enolase, Leu‐7, leucocyte common antigen or lysozyme/alpha‐1‐antitrypsin. Ultrastructure revealed typical whorled cytoplasmic aggregates of intermediate filaments. These studies along with literature review reveal the heterogeneous immunohistochemical profiles of these tumors with common morphologic features. While the histogenesis of these tumors remain uncertain, it is necessary to recognize that these aggressive neoplasms may occur primaril

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1988.tb00529.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

We report a female patient, now aged 60, followed for 20 years for lesions originally diagnosed as necrobiosis lipoidica diabeticorum. In fact, the anatomical and clinical features of her disorder correspond to the new entity described as necrobiotic xanthogranuloma. Two elements distinguish this from earlier cases: 1) two examinations failed to reveal paraproteinemia; 2) there was transepithelial elimination of cholesterol crystals and degenerated xanthomatous cell debris via hair follicles. This demonstrates the characteristic histology of the disorder and indicates that the diagnosis of necrobiotic xanthogranuloma should be considered even in the absence of paraproteinemia.

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1988.tb00530.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY