摘要:

A multistep immunocytochemical method, utilizing horseradish peroxidase as an immunological bound marker enzyme, was employed to demonstratein vivofixed immunoglobulins (IgG, IgM) in the skin of three patients with CDLE and three patients with SLE. The immunoglobulin deposits were confined to the uppermost strata of the dermis, i.e. the area just below the basal lamina. Small amounts of immunoglobulin were visible within the lamina lucida and the basal lamina. Only quantitative differences were observed between deposits of immunoglobulins in CDLE and SLE. In CDLE, the reaction product covered a wider area of the superficial dermis and extended deeper down into the dermis. IgG and IgM deposits exhibited an identical fine structural morphology.

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1978.tb00961.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Three fibrous histiocytomas, primary in skin, were studied by light and electron microscopy and by frozen section histochemistry. The term malignant was applied to cutaneous tumors which demonstrated aggressive multinodular local growth, including angioinvasion and/or extension into bone, muscle, and fascia. Metastases were not found. Strongly positive reactions for hydrolytic enzymes, particularly acid phosphatase will help differentiate malignant fibrous histiocytoma from most other primary soft tissue malignancies of skin. Electron microscopic studies reaffirm the presence of both histiocyte‐like and fibroblast‐like cells. Langerhans' granules were not identified. Primary malignant fibrous histiocytoma of skin may have a prognosis superior to homologous tumors arising in deeper soft tissue and the retroperiton

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1978.tb00962.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Four cases of recurrent digital fibroma of childhood are presented, bringing the total of reported cases to 79. From our material and a review of the literature, the most characteristic features of this entity are delineated. There is no predilection for either sex. Seventy‐three percent (58 cases) occurred under one year of age with 14 observed at birth; only four patients were over 5‐years‐old and the oldest was 15. The localization is highly diagnostic, being limited to the second to fifth carpal and pedal digits and no reported involvement of thumbs or great toes. Two cases were observed in the sole and ulnar side of the hand but associated with others in classical locations. In 50% of cases, the lesions are single at the time of diagnosis. The recurrence rate, based upon cases with adequate follow‐up, was found to be 75%. To our knowledge no metastasis has ever been reported. The histology is that of a well‐differentiated fibroblastic tumor with pathognomonic eosinophilic cytoplasmic inclusion bodies. A review of the available electron microscopic data is presented and the histogenesis is

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1978.tb00963.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Sixteen cases of pruritic papules of pregnancy were collected during a 32‐month period. This dermatosis was introduced to the literature in 1962 but no histopathologic study of it has been published. Histopathologic presentation of pruritic papules of pregancy is that of toxic dermatitis. This finding is not characteristic of this condition and clinico‐pathologic correlation is needed for a definitive diagno

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1978.tb00964.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Inflammation in inflammatory seborrheic keratoses was found to be composed of mononuclear cells, particularly lymphocytes. Accumulations of mononuclear cells in the papillary and subpapillary dermis frequently showed no tendency to infiltrate the epithelium. However, dramatic interaction of the seborrheic keratosis and the inflammatory process also was common. The lymphocytic exocytosis into the epithelium followed two basic patterns: eczematous, characterized by intercellular and intracellular edema, microvesicle formation, and epithelial necrosis; and lichenoid, in which a bandlike infiltrate attacked the dermoepidermal junction and hyaline bodies occurred in the infiltrated epithelium and in the dermis. Epithelial changes consisted of necrosis of epithelial cells and related parakeratosis; squamous eddies were occasionally found. Inflammatory cell infiltration in seborrheic keratoses possibly represents a process other than irritation, and we propose that mononuclear cell infiltration in seborrheic keratoses may be related to an involutionary process.

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1978.tb00965.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

This case proves the possibility of a malignant transformation of seborrheic keratosis. This evidence is furnished by a biopsy specimen that shows not only a topical relationship between seborrheic keratosis and Bowen's disease, but also the progressive transition. An evident biopsy has to be made prior to clinical suspicion of malignant degeneration, that means prior to the destruction of the transitional zone by the tumor.

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1978.tb00966.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Lesions of seborrheic keratoses studied by transmission electron microscopy showed an unusually large number of Langerhans cells in the epidermis. The role of Langerhans cells in the development of these lesions needs further study.

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1978.tb00967.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1978.tb00968.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1978.tb00969.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1978.tb00970.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY