摘要:

Electron microscopy of lentigines was performed to study the pigmentation abnormality in two children with LEOPARD syndrome. Giant melanosomes similar to those seen in café‐au‐lait spots of neurofibromatosis and nevus spilus were found in a lentigine from one of our cases. Our results show that „spherical granular melanosomes” described in neurofibromatosis, are lysosomal‐like structures associated with the development of complex melanin granules. Our study also demonstrates that immature melanosomes are present in some keratinocytes of LEOPARD syndrome. This finding is in contrast to the prevailing concept that only mature melanosomes are transferred to keratinocytes. The occurrence of individual melanosomes of normal size and shape in keratinocytes of skin in whites with LEOPARD syndrome, suggests that neither the size of melanosomes, nor the racial differences are the factors determining the distribution of melanosomes in ker

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1976.tb00865.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

One hundred thirty‐eight patients who presented with solitary cutaneous lesions appearing clinically as papules or plaques and histologically showing a lichenoid tissue reaction were studied. Many of the lesions occurred in sites not usually exposed to sunlight and histologically the lesions did not show significant atypical change in keratinocytes and many did not show evidence of solar elastosis in the superficial corium. Our study indicates that the lesions are benign keratoses showing a lichenoid tissue reaction or lichenoid benign keratose

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1976.tb00866.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Five patients with osteoporosis were treated with human growth hormone (hGH) for a year and the changes in their skin were studied by light and electron microscopy. The abnormally thin skin of osteoporosis appeared to change towards normal after treatment with hGH. There was a consistent proliferation of blood vessels, and increased number of mast cells and fibrocytes. The collagen bundles and elastic tissue fibers appeared hyperplastic and more horizontally oriented. The fine, vertical elastic fibrils of the papillary dermis had appeared decreased before treatment, but seemed to be restored to their normal configuration after treatment. Since there was no evidence of stimulation of hair, sebum, or melanin such as occurs in acromegaly, it is suggested that the scope of the direct action of hGH on the skin is limited to mesenchymal structures.

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1976.tb00867.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Deposits of C3 have been demonstrated at the dermo‐epidermal junction in the lesions of experimental cutaneous candidiasis in guinea pigs. The deposits were granular in character and similar to those previously found in the lesions of chronic mucocutaneous candidiasis in humans. Immunoglobulin, C4 and candida antigen were not detected in the lesions. C3 was also found in a similar pattern at the dermo‐epidermal junction of candida‐infected skin from homozygous C4‐deficient guinea pigs. From these observations, it is postulated that complement deposition occurs in these lesions as a result of alternative pathway activation, perhaps by cell wall components from the infecting or

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1976.tb00868.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

A sebaceous gland tumor on the back of a 28‐year‐old man underwent periodic exudation of yellowish material in association with local irritation. Pathological examination revealed entire sebaceous gland lobes lying subcorneally in the orifices of sebaceous follicles. This case appears to represent transfollicular extrusion of sebaceous gland lobes as a natural phenomenon rather than as an artif

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1976.tb00869.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1976.tb00870.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1976.tb00871.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY