ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1993.tb00676.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

Proliferating cell nuclear antigen (PCNA) grade (a semi‐quantitative assessment of the entire tumor profile) and estimation whether PCNA grade is low (0–50% positive cells) or high (51–100% positive cells) has been demonstrated to be of prognostic significance in gastric carcinoma. Sixteen vertical growth phase melanomas with 8 or more years of clinical follow‐up were reacted with antibody to PCNA. PCNA grade was independently evaluated by both authors without knowledge of clinical outcome. PCNA grade was subsequently correlated with clinical outcome and other prognostic indicators. Agreement in assigning PCNA grade was noted between the two observers in 13/16 cases. However, PCNA grade failed to accurately predict patient survival or death. Additionally, PCNA grade was not significantly correlated with other recognized prognostic attributes. While interpretation of the prognostic significance of PCNA grade based upon this small series of cases should be conservative, a semi‐quantitative estimate of PCNA‐positive cells appears to have little utility in predicting the clinical outcome in maligna

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1993.tb00677.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

Dermal dendrocytes comprise a subset of spindle‐shaped cells which normally reside in the dermis. While they appear to play some role in the reticuloendothelial system, their exact functions have not been completely elucidated. In addition to their purported immunologic functions, it has been suggested that dermal dendrocytes may play an inhibitory role in the regulation of dermal collagen synthesis. We examined 7 collagenomas with antibodies directed against factor XIIIa (FXIIIa) in order to test the hypothesis that dermal dendrocytes were focally diminished in these hamartomatous overgrowths of collagen. In all cases, there was a marked diminution in the number of FXIIIa‐positive cells in the lesional dermis when compared to the surrounding dermis. Our data support the hypothesis that dermal dendrocytes may be involved in regulation of collagen synthe

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1993.tb00678.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1993.tb00679.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1993.tb00680.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1993.tb00681.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1993.tb00682.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY