摘要:

We report 6 cases of an immature variant of trichoepithelioma which histologically appears to show differentiation toward the primitive hair germ. The lesions presented in mature adults (mean age 44 years). Four occurred in men and 2 in women. Four lesions occurred on extremities, an unusual location for trichoepitheliomas. Histologically, the lesions were characterized by well‐circumscribed, but unencapsulated, dermal collections of small tumor lobules composed of basaloid cells with invaginations resembling primitive dermal hair papillae. There was no adenoidal growth pattern or horn cyst formation. The separation of the immature lesions from those of classical trichoepithelioma and basal cell carcinoma can be made if multiple morphological features are considered; no one particular finding is diagnostic. The major differential features between the immature trichoepithelioma and basal cell carcinoma are circumscription, tumor lobule uniformity, occasional immature hair germs, and lack of retraction artifact of the tumor lobules from the stroma. The differential features between the immature and classical trichoepithelioma are less conspicuous. The immature form typically exhibits no horn cysts, displays fewer primitive hair structures, and lacks the adenoidal growth patterns of the tumor lobules which are usually present in the classical trichoepithelioma

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1988.tb00564.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Biopsies of morpheaform basal cell carcinomas (MBCCs) were separated into 2 groups based on histological features: 1) a pure morpheaform group with narrow elongated strands of basaloid cells in a dense fibrous stroma; and 2) a complex morpheaform group with pure morpheaform regions as well as regions with other histological patterns (nodular, etc.). Analysis by sex and body location revealed a female predominance in the pure morpheaform group. Lesions were found primarily on the mid‐face in women with pure MBCCs. Using a monoclonal antibody which identifies eccrine duct in routinely fixed tissues, we could not identify eccrine ductal differentiation in MBCC

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1988.tb00565.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Epidermal Langerhans cells (LC) from skin of clinically normal appearance in psoriatics were studied electron microscopically and compared with LC from the skin of healthy volunteers and from those with other dermatoses. Results show that LC from psoriatics display partly distinct cytoplasmic alterations. Moreover, about half of LC investigated were partly or mainly surrounded by clearly widened intercellular spaces, such that an immediate cellular contact with neighbouring keratinocytes was correspondingly decreased. Whether such LC are functionally altered remains to be clarified.

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1988.tb00566.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

The presence of 43 kDa papain inhibitor in 43 different skin diseases was immunohistochemically studied by using both poly‐and monoclonal antibodies. Psoriasis and various eczematoid reactions as well as viral infections showed the most pronounced staining in the squamous cells of the epidermis. The antigen was also present in benign tumours or precancerous lesions which showed keratinization. Cells of poorly differentiated squamous cell carcinomas, basal cell carcinomas and melanocytic tumours were negative. The antigen seems to be related to disturbed keratinization and benign proliferation in non‐neoplastic derma‐toses and it is also present in differentiating squamous neop

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1988.tb00567.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Two human melanoma cell lines (OAL‐1 and OAIy‐2) were obtained from primary tumors. Electron microscopy and indirect immunofluorescence for S‐100 protein and human melanoma associated antigen p97a were used to characterize the cell lines. Ultrastructural correlation between primary tumor cells and cultured cells was investigated. The ultrastructural features of OAL‐2 cells were similar to those of primary tumor cells. However, OAL‐1 cells showed a fibroblast‐like appearance, quite different from that of the primary tumor cells. This fibroblast‐like appearance persisted after 50 subcultures of the OAL‐2 cell line and suggests cellular dedifferentiation. No spontaneous re‐differentiation of the cells to the original phenotype of the primary tumor cells was observed even aft

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1988.tb00568.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

A long‐standing tumor of scalp is reported characterized histologically by extensive proliferation of pilar epithelium made up exclusively of cells with small round nuclei and clear cytoplasms containing glycogen granules. The tumor epithelium showed no tendency for keratinization and no cytologic atypia. The growth, however, appeared aggressive and replaced the entire thickness of the dermis and extended into the subcutaneous fat tissu

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1988.tb00569.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

A 51‐year‐old imunosuppressed man presented with ulcerations of the abdominal wall. Biopsy of the ulcer margin was necessary for the diagnosis of cutaneous cryptococcosis. Since a variety of opportunistic organisms can present with non‐specific cutaneous lesions, these infections must be ruled out by tissue diagnosis of all immunosuppressed patients. A review of 22 additional cases is included together with electron microscopic fin

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1988.tb00570.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

A ease of porokeratotic eccrine ostial and dermal duel nevus (PEODDN) affecting all 4 extremities is described. Clinically, palmo‐plantar lesions resembled those of nevus comedonicus and the remaining lesions those of linear verrucous epidermal nevus. Histologically, all lesions were identical with cornoid lamellae in the eccrine ostia and epidermal duct

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1988.tb00571.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

We report an unusual case of sebaceous gland hyperplasia manifested clinically as a large solitary intracutaneous nodule, which was at first diagnosed as an epidermoid cyst. Histologically, the nodule consisted of a single large central cavity connected with numerous fully‐matured sebaceous glands. We discuss the unique clinical appearance and its histopathological differential diagnosis including sebaceous adenoma, sebaceous trichofolliculoma, organoid nevus and sebaceous gland hyperplasi

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1988.tb00572.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

A 68‐year‐old male with a myclodysplastic syndrome developed a bulla on his right thigh. A skin biopsy revealed a subepider‐mal cleavage containing fibrin and a mononuclear cell infiltrate exhibiting prominent erylhrophagocytosis. Erythrophagocytosis by mononuclear cells was present, to a lesser extent, throughout the dermis and in the subcutis. Immunoperoxidase studies with anti‐lysozyme and anli‐alpha‐1‐chymotrysin confirmed the histiocytic nature of the phagocytic cells. Only a few prior reports of cutaneous erythrophagocytosis exist in the literature. In contrast to the generally grave clinical manifestations of the patients described in previous publications documenting erythrophagocytosis, this patient lacked a concomitant hematologic deterioration or serious sys

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1988.tb00573.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY