摘要:

The ultrastructural features of lesions from three patients with transient acantholytic dermatosis of the type resembling Darier's disease by light microscopy were studied. The cellular changes appeared to reflect a mixture of acanthosis, acantholysis, dyskeratosis and cytoplasmic vacuolization which varied to a certain extent with the age of the lesion. The electron microscopic findings could not be distinguished from those of Darier's disease and it is suggested that the pathologic events in both diseases may reflect disturbances of the normal maturation of epidermal cells, rather than the production of unique lines of cells.

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1975.tb00834.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Patients with Xeroderma Pigmentosum (XP) frequently exhibit small, white hypopigmented spots on the parts of the body not exposed to the sun. These hypopigmented spots, 1–5 mm in diameter, appear early in the life. Punch biopsies were performed for electron microscopic studies and DOPA reaction. Melanocytes were either absent or occasionally found along the basal layer of the hypopigmented area; Langerhans cells were numerous; DOPA positive cells were rare or absent. Thus a vitiligo‐like syndrome is realized. In clinically normal skin, Langerhans cells were observed within the basal layer. These findings may help explain the clinical appearance of the white macules and the fact that the absence of pigment protection on sun exposed areas exposes the skin widely to UV radiation. It seems logical to propose that apart from the genetic enzymatic defect of XP, there is a genetic melanocytic abnormality leading to conditions which increase the general sensitivity to UV radiat

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1975.tb00835.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

In an attempt to determine the viral content and to observe the morphological features of clear cells in human warts of various clinical types, 17 lesions were studied with the electron microscope and 26 in thick sections. Plantar warts were, by far, the richest in viral particles, which are often found in crystalline arrangement. Morphologically, three groups observed in thick sections were also discovered with the electron microscope. In flat warts, poor in keratohyaline, the vacuolating process was total and massive, with abundant viral particles in the nucleus; two flat warts were taken from immunosuppressed patients and their appearance was quite similar to epidermodysplasia verruciformis lesions. In common warts, poorer in virus particles but rich in keratohyaline, vacuolization was often not complete. In plantar warts, characterized by their peculiar wealth in viral particles sometimes invading the cytoplasm, the production of keratohyaline was tremendous and the vacuolization, although often complete, was, however, not massive. Thus it seems that keratohyaline production is related to viral production but hampered by the vacuolating process and differing according to the ultrastructure of the three types of warts. It is suggested that the oncogenic potential of a wart (papilloma) may be related to decrease in keratohyaline production, i.e. cell maturation, and increase in vacuolization.

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1975.tb00836.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

The following findings were striking in two young patients, suffering from mycosis fungoides: 1) paracrystalline bodies, probably of a proteic nature, both in the cytoplasm of well‐preserved mycosis fungoides cells and in cells undergoing degeneration; 2) a remarkable number of mast cells mixed with mycosis fungoides cells and mast cell granules in the intercellular spaces of the epidermis, close to Pautrier's abscesse

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1975.tb00837.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1975.tb00838.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1975.tb00839.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY