摘要:

The majority of findings in relation to warts have been passed on from one textbook to the other since the end of the last century. More recent studies have been carried out with the electron microscope. But information is lacking as to histology, histochemistry, examination with the phase‐contrast microscope, with the interference microscope, microradiography and other new techniques. Warts are a proliferation of the epidermis caused by a virus, and we know that the culprit acts in the epidermis itself. Warts are acanthomas, and a transition to malignancy is possible in predisposed persons. It is most remarkable that in the malignant tumors of epidermodysplasia verruciformis, no virus could be found. As the demonstration of viruses with the electron microscope and other techniques cannot be made as a matter of routine, we have to search for a simpler method with the light microscope. With the application of more elaborate procedures, new information about epidermal proliferation will certainly be obtaine

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1978.tb00938.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Six examples of basal cell epithelioma were compared to fetal and adult skin. Five parameters were used in this study: abnormally large aggregates of melanosomes in epithelial cells; the paucity of half‐desmosomes; the increase of microfilaments in the cell periphery; clustered membrane‐limited granules; and desmosome‐like structures of stromal fibroblasts. All of these indicators were positive in both basal cell epithelioma and fetal hair follicle; but they were negative in both fetal and adult epidermis. Therefore, it was concluded that basal cell epithelioma seems to mimic fetal primary epithelial germ. Interestingly, stromal fibroblasts of basal cell epithelioma phagocytize collagen fibers, and membrane‐limited granules were found both inside and outside the tumor cells facing the digested collagen stroma. In view of the collagenolytic activity of the homogenate of basal cell epithelioma, membrane‐limited granules might represent zymogen granules for col

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1978.tb00939.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Direct immunofluorescence investigations were performed on skin biopsies from five patients with granuloma eosinophilicum faciale (GEF; facial granuloma). An extensive and brilliant granular picture was observed along the basement membrane (BM) of the epidermis and the hair follicles, in the walls of the vessels, in the cellular infiltrates and on the connective tissue fibers. These granules were positively stained by antisera directed against IgG, complement (C3/4) and, although less consistently, against IgA and IgM. IgE was found in one case along the BM, but anti‐ IgD was negative. Concomitantly heavy fibrillar deposits of fibrin were present in the walls of the vessels and in the cellular infiltrates, together with granular depositions along the BM. The analysis of the complement factors showed that Clq, C4, C3, C3c, C3d and C5 were present in the same pattern as C3/4. These results indicate that GEF can be considered as a chronic form of leukoclastic vasculitis mediated by an Arthus‐like mechanism, maintained by an unidentified, persistent antigen or by locally produced Ig aggrega

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1978.tb00940.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1978.tb00941.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

A case is described in which the initial clinical and histological features were suggestive of rosacea. Subsequent progress revealed the diagnosis to be chronic lymphatic leukemia. The initial biopsy specimens were reviewed and small but definite quantities of follicular mucinosis were noted after appropriate staining. If this had been noted earlier the diagnosis would have been made more rapidly. This case demonstrates the importance of detecting follicular mucinosis. We are not aware of follicular mucinosis having been described in association with chronic lymphatic leukemia previously. It is also rare for leukemias other than the monocytic type to present with cutaneous lesions, though skin lesions may occur in established cases.

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1978.tb00942.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

A case report of condyloma acuminatum of the nipple with electron microscopic demonstration of intranuclear Papovavirus‐like particles, in a patient with Darier's disease, is presente

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1978.tb00943.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1978.tb00944.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1978.tb00945.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY