摘要:

The internal organization of plasma membranes was studied in seven subjects with pemphigus vulgaris and in one subject with familial pemphigus using the freeze‐fracture technique. The results obtained seem to suggest that the acantholytic process is produced in a similar fashion whatever the pathogenic agent and that desmosomes represent the “target” membrane specializations in the acantholytic phenomena. The reduction and eventual disappearance of desmosomal particle aggregations is seemingly accompanied by an increase in gap junc

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1980.tb01184.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

Chondrodermatitis nodularis helicis is a chronic disorder occurring exclusively on the ear. It is most common in the sixth decade, and two thirds of the patients are men. Although it has no single characteristic histologic feature, a diagnosis can be made with certainty with a clinical history and a combination of morphologic changes seen in the cartilage and overlying skin. The natural history and histology are similar to a group of disorders characterized by transepithelial elimination known as the perforating dermatoses.

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1980.tb01185.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

Dowling‐Degos' anomaly is characterized by a reticular and spotted pigmentation of the skin folds; this pigmentary disturbance, occurring most often in women, is a dominant inherited genodermatosis which worsens progressively and may exhibit in the early phase rapid changes in severity after emotional stress. In a 9‐year‐old girl, an electronmicroscopic study of pigmented lesions showed a strong melanocytic activity with quantitative increase of the melanosomes; the average size of the melanosomes was not different when compared to normal Caucasoid skin, but in the keratinocytes they were distributed according to a dispersed pattern as in black skin. The pigmentary state of Dowling‐Degos' disease is another example of melanocyte‐keratinocyte interaction where the epidermal melanin pattern and the size of pigment granules are not in striking correlation. An accelerated rate of melanogenesis and pigmentation may be another factor determining a non‐aggregated distribution of the melanosomes within the keratinocytes. The nature of the stimulus of pigmentation in these skin areas which are not sun‐exposed is

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1980.tb01186.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

Five different cases of verrucous proliferative lesions of skin are described and discussed. One of each developed in a chronic ulcer on a heel, in a scar on a lower leg, and on the penis, and two appeared in the region of the buttock in relation to chronic inflammatory sinuses. All these lesions showed morphological and clinical features of verrucous carcinoma which are described. It has been concluded that the variously named verrucous lesions in the literature (epithelioma cuniculatum, florid papillomatosis, giant cutaneous papilloma and papillomatosis cutis carcinoides), as well as our five cases represent a verrucous carcinoma which is a particular type of squamous cell carcinoma. This tumor develops typically in moist areas which are frequently sites of chronic inflammation. Despite the favorable prognosis, it is a potentially invasive tumor.

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1980.tb01187.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

This is a report on a 67‐year‐old female patient with Graves' disease and extensive pretibial myxedema. Linear IgM deposits were observed in the basement membrane zone by direct immuno‐fluorescence. These deposits were found, by immunoelectron microscopy, to be haphazardly distributed in the uppermost dermis without any correlation to preexisting structures. An amorphous material that coated not only the surface of fibroblasts and collagen bundles but was also present within the dilated endoplasmic reticulum of the fibroblasts was the predominating pathological finding at the ultrastructural level. Mast cells were morphologically normal. These results support previousin vivoand recentin vitrofindings indicating that the fibroblast plays a major role in the pathogenesis of pretibial myx

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1980.tb01188.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

Cellular blue nevus can be clinically and histogenetically confused with malignant melanoma but remains a benign neoplasm of uncertain histogenesis. This paper reports the ultrastructural features of three cases of cellular blue nevus and emphasizes melanosomal alterations, including immature and granular forms, multiple layers of basement membrane around vessels, nerve fibers and tumor cells; endothelial fenestrations and banded structures within the nerve and outside in the stroma. A unifying concept of neural crest derived tumors is presented to better understand the histogenesis of cellular blue nevus.

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1980.tb01189.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1980.tb01190.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY