ISSN:0148-6071    

DOI:10.1177/014860717800200201

出版商:SAGE Publications    

年代:1978

数据来源: WILEY

ISSN:0148-6071    

DOI:10.1177/014860717800200202

出版商:SAGE Publications    

年代:1978

数据来源: WILEY

ISSN:0148-6071    

DOI:10.1177/014860717800200203

出版商:SAGE Publications    

年代:1978

数据来源: WILEY

ISSN:0148-6071    

DOI:10.1177/014860717800200204

出版商:SAGE Publications    

年代:1978

数据来源: WILEY

摘要:

Free essential “fatty acids (EFA) are reported to suppress cell‐mediated immunity. Because Intralipid contains a high concentration of esterified EFA, the effects of this emulsion onin vitrolymphocyte transformation were studied. Intralipid concentrations of 11.5,115, and 230 mg% in lymphocyte cultures increased phytohemag‐glutinin (PHA) stimulation by an average of 8.2% (not significant [NS]), 18.1%(p<0.01), and 11.8% (NS), respectively. These same concentrations also increased Varidase stimulation in lymphocyte cultures by an average of 11.3 (p<0.02), 18.9 (p<0.02), and 4.4% (NS), respectively. Control wells did not demonstrate allergic reactions to Intralipid. These data demonstrate that Intralipid can significantly increase the mitogenic response of human thymic lymphocytes and the antigenic response of human lymphocytes,in vitro.

ISSN:0148-6071    

DOI:10.1177/014860717800200205

出版商:SAGE Publications    

年代:1978

数据来源: WILEY

ISSN:0148-6071    

DOI:10.1177/014860717800200206

出版商:SAGE Publications    

年代:1978

数据来源: WILEY

ISSN:0148-6071    

DOI:10.1177/014860717800200207

出版商:SAGE Publications    

年代:1978

数据来源: WILEY

摘要:

Stress or injury‐induced phenomena, such as impaired wound healing and immune depression, may be related to impaired function of certain leukocyte populations. Since vitamin A prevents some aspects of stress, we studied its effect on various white cell populations in normal and injured rats. Supplemental vitamin A (150,0001U/ kg chow) to normal rats resulted in marked increases in thymic weight and lymphocytes without any ellect on adrenal weight. The basal chow contains 13,700 IU vitamin A per kg. In rats subjected to moderately severe injury (dorsal wounding or unilateral femoral fracture), supplemental vitamin A greatly diminished the thymic involution observed in chow‐fed controls and delayed or minimized the accompanying adrenal hypertrophy. In uninjured rats, supplemental vitamin A induced in three to four days a temporary circulatory leukocytosis characterized by lymphocytosis, monocytosis, and a relative neutropenia. These changes in the blood picture persisted one day after femoral fracture. On the second and third day postfracture the lymphocyte and neutrophil values returned to normal while the monocytosis persisted. Polyvinyl alcohol sponges implanted next to the fracture site demonstrated that supplemental vitamin A consistently increased the number of white blood cells migrating into the wound area and showed significantly larger numbers of monocytes/macrophages. These data suggest that vitamin A influences the numbers and nature of white cells involved in immune, inflammatory, and wound healing processes. In addition to the known antiglucocorticoid activity of vitamin A, these effects may represent a direct beneficial action of dietary vitamin A supplements for stressed and injured animals.

ISSN:0148-6071    

DOI:10.1177/014860717800200208

出版商:SAGE Publications    

年代:1978

数据来源: WILEY

ISSN:0148-6071    

DOI:10.1177/014860717800200209

出版商:SAGE Publications    

年代:1978

数据来源: WILEY

ISSN:0148-6071    

DOI:10.1177/014860717800200210

出版商:SAGE Publications    

年代:1978

数据来源: WILEY