摘要:

In order to assess the diagnostic validity of a new test of tone duration discrimination (TDD), we tested elderly subjects, 32 Alzheimer-type (AD) and 11 vascular-type dementia (VAD) patients, 11 memory-impaired (MI), and 21 healthy controls with a TDD test as well as with 18 standard neuropsychological (NP) tests. The TDD test efficiently discriminated demented patients from MI, and MI from controls. As an index of cognitive impairment, the TDD test was sensitive also in comparison to NP tests. This suggests that processing of auditory duration information is impaired in dementia as well as in MI. Patients suffering from AD and VAD differed in that the VAD but not the AD patients improved their TDD performance when the interstimulus interval was lengthened. This shows that the processing of auditory temporary information involves functions sensitive to dementia diseases as well as to MI. The TDD test could add discriminatory power in diagnosis and differential diagnosis of dementia.

ISSN:1420-8008    

DOI:10.1159/000106600

出版商:S. Karger AG    

年代:1997

数据来源: Karger

摘要:

The subject presented with intellectual decline followed by progressive muscle weakness of the bilateral upper limbs when he was 60 years old. He had a point mutation (methionin-valine) at 129 prion protein codon. He died at the age of 63 and necropsy revealed bilateral frontal lobe atrophy. The frontal cortex showed neuronal cell loss in layers II and III with spongiform change. Reusche silver impregnation technique for β-peptide combined with ubiquitin immunostaining revealed perineuronal structures encircling degenerated neurons and ubiquitin-immunoreactive (IR) dot-like deposits. They were distributed particularly in the temporal neocortex and entorhinal cortex. They differed from either classic senile or diffuse plaque by the absence of amyloid core in the center and of amyloid fibrils. Ubiquitin-IR materials were also found as neuronal inclusions in the hippocampal granular cells. Nigral degeneration and neuronal loss in the hypoglossal nerve nucleus and in the anterior horn of the spinal cord were also found and spinal cord motoneurons had Bunina body inclusions. The clinical features and pathological findings were consistent with non-Alzheimer dementia with status spongiosus and neuronal cell loss. The unusual perineuronal structures found in our case might be a specific cellular pathology of dementia of the frontal lobe type

ISSN:1420-8008    

DOI:10.1159/000106601

出版商:S. Karger AG    

年代:1997

数据来源: Karger

ISSN:1420-8008    

DOI:10.1159/000106602

出版商:S. Karger AG    

年代:1997

数据来源: Karger

ISSN:1420-8008    

DOI:10.1159/000106668

出版商:S. Karger AG    

年代:1997

数据来源: Karger