摘要:

SYNOPSIS.A reduction in the growth temperature ofTetrahymena pyriformisstrain WH‐14 from 35 C to 15 C resulted in distinct alterations in the fatty acid composition of the glycerophospholipids. The proportion of normal saturated acids declined from 26 to 19%; palmitoleic acid increased by 6%, and the composition of the polyunsaturated fatty acids increased in 18:2 Δ6,11(n) and decreased in 18:2 Δ9,12(n) and 18:3 Δ6,9,12(n). The unsaturation index (the average number of double bonds/100 molecules) did not change with a shift in temperature.Two biosynthetic pathways exist inTetrahymenafor the formation of unsaturated fatty acids. The observed changes in fatty acid composition that accompany a lowering of the environmental temperature can be accounted for by a reduction in the accumulation of products of the fatty acid pathway leading to the formation of γ‐linolenic acid [16:0(n) → 18:0(n) → 18:1 Δ9(n) → 18:2 Δ9,12(n) → 18:3 Δ6,9,12(n)] and an increase in the components of the pathway leading to the formation of 18:2 Δ6,11(n) [16:0(n) → 16:1 Δ9(n) → 18:1 Δ11(n) → 18:2 Δ6,11(n)]. The data suggest that the regulatory mechanism inTetrahymenadiffers from that found in some bacteria where a simple substitution of unsaturated fatty acids for saturated fatty acids occurs

ISSN:0022-3921    

DOI:10.1111/j.1550-7408.1976.tb05269.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Book reviewed in this article:Albert, A. 1975.The Selectivity of Drugs.

ISSN:0022-3921    

DOI:10.1111/j.1550-7408.1976.tb05270.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

ISSN:0022-3921    

DOI:10.1111/j.1550-7408.1976.tb05271.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY