摘要:

AbstractThe hypoglycaemic activity of the extract of the crude drug ‘Yvahai’ (Hexachlamys edulis, Myrtaceae) was assessed on normoglycaemic and alloxan‐diabetic rats. After 7 days of oral treatment at 100 mg extract/kg body weight, Yvahai significantly reduced glycaemia in normal (p<0.02) and diabetic (p<0.05) rats during an oral glucose tolerance test. The maximum effect was observed between 1.5 and 2.5 h after glucose administration in normoglycaemic rats, and at 1.0 h in diabetic animals. The extract, however, did not have a statistically significant effect on the basal glycaemia of untreated compared with treated rats. A single oral dose of 500 mg extract/kg administered to normoglycaemic rats 1 h before glucose, elicited a significant reduction (p<0.02) in the percent increase in glycaemia compared with vehicle‐treated animals. The effect was comparable to a single oral dose of 100 mg/kg tolbutamide. During the oral toxicity study, animals exhibited no symptoms of drug‐induced toxicity with doses up

ISSN:0951-418X    

DOI:10.1002/ptr.2650060112

出版商:John Wiley&Sons, Ltd.    

年代:1992

数据来源: WILEY

摘要:

AbstractSeveral specimens of garlic bulbs (Allium sativumL., fresh sap and rehydrated dry powder), as well as a few otherAlliumspecies, were assayed for their ability to inhibit the enzyme adenosine deaminase (ADA). A clear dose‐dependent inhibition of enzyme activity, leading to an accumulation of the substrate adenosine (Ado) in the system, was observed. A standardin vitrotesting procedure was derived which is suitable for quality assessment of either raw or dried garlic, as well as for bioequivalence control of pharmaceutical products derived therefro

ISSN:0951-418X    

DOI:10.1002/ptr.2650060113

出版商:John Wiley&Sons, Ltd.    

年代:1992

数据来源: WILEY

摘要:

AbstractThioacetamide (100 and 200 mg/kg s.c.) reduced the volume of bile secretion by 33.1–50.6% and this was accompanied by a reduction in bile acids (31–54%) and bile salts (60–61%) in conscious rats and anaesthetized guinea‐pigs. A significant reversal of these effects was achieved by pretreatment with picroliv, the hepato‐protective principle ofPicrorhiza kurrooa, in a dose dependent manner against thioacetamide‐induced cholestasis. Picroliv was found to be more active than silymarin in both experimental models of

ISSN:0951-418X    

DOI:10.1002/ptr.2650060114

出版商:John Wiley&Sons, Ltd.    

年代:1992

数据来源: WILEY

ISSN:0951-418X    

DOI:10.1002/ptr.2650060115

出版商:John Wiley&Sons, Ltd.    

年代:1992

数据来源: WILEY

ISSN:0951-418X    

DOI:10.1002/ptr.2650060101

出版商:John Wiley&Sons, Ltd.    

年代:1992

数据来源: WILEY