摘要:

AbstractThe present results show that the association of plant extracts, Euphytose®, interacts with central benzodiazepine (BDZ) receptors, alpha‐2 adrenoceptors and muscarinic M1 receptors with respective IC50values of 37.1, 3.6 amd 30.0 μg/mL. In contrast, Euphytose® does not show any interaction with peripheral BZD, 5‐HT1 and 5 HT2 serotoninergic, alpha‐1 adrenergic, DA1 and DA2 dopaminergic and M2 muscarinic receptors. The presentin vitrobinding data demonstrate clearly the different interactions of Euphytose® with various neurotransmitter binding sites in the central nervous system. This is of importance in order to elucidate the mechanism of action of the putative anxiolytic and/or antidepressant effect of

ISSN:0951-418X    

DOI:10.1002/ptr.2650050602

出版商:John Wiley&Sons, Ltd.    

年代:1991

数据来源: WILEY

摘要:

AbstractMale Wistar rats were divided into four equal groups: (i) controls, (ii) animals exposed to organic solvents, (iii) animals exposed to organic solvents and receiving pollen extracts, (iv) rats given pollen extracts. The experiment lasted 3 months. The protective effect of pollen extracts against changes evoked by organic solvents was demonstrated. Pollen extracts inhibited or counteracted the elevation of aminotransferases and alkaline phosphatase activity and lipid and carbohydrate metabolism disturbances in the liver. The ascorbate system was improved. It is concluded, that pollen extracts are able to protect the liver against changes evoked by environmental influences.

ISSN:0951-418X    

DOI:10.1002/ptr.2650050603

出版商:John Wiley&Sons, Ltd.    

年代:1991

数据来源: WILEY

摘要:

AbstractCrude extracts obtained from leaves ofCedrela tubiflora(CT) (Meliaceae family) show antiviral and virucidal effects against several viruses. Herpes simplex, pseudorabies and vesicular stomatitis viruses were extremely susceptible and a reduction of 3–5 log in infectivity occurred after 15 min of direct incubation with the plant extract. By contrast, poliovirus and the Tacaribe arenavirus are inhibited intracellularly. The inhibitory action is dose dependent and no cytotoxic effects were detected on Vero cells after 2 days of CT treatmen

ISSN:0951-418X    

DOI:10.1002/ptr.2650050604

出版商:John Wiley&Sons, Ltd.    

年代:1991

数据来源: WILEY

摘要:

AbstractFresh leaves ofBaphia nitidasupplied by a herbalist were extracted, screened phytochemically and then subjected to various pharmacological tests. The phytochemical tests showed the presence of saponin, flavonoid glycosides and true tannins. In the dose range used, no acute toxicity was observed for the ethanolic extract. The extract showed a dose dependent antinociceptive (analgesic) activity in mice with the analgesic activity of 500 mg/kg extract being comparable to that of 300 mg/kg of acetylsalicylic acid. The extract demonstrated an antidiarrhoeal effect by protecting rats against castor oil induced diarrhoea. This was also dose related but less than the protection afforded by sodium salicylate. The extract did not demonstrate any appreciable anticonvulsant effect against strychnine‐induced convulsion in rat

ISSN:0951-418X    

DOI:10.1002/ptr.2650050605

出版商:John Wiley&Sons, Ltd.    

年代:1991

数据来源: WILEY

摘要:

AbstractThe effects of CBD, a potent analgesic cannabinoid on LTB4and TXB2production stimulated by A23187 was determined in mouse bloodex vivoand in human polymorphonuclear cellsin vitro. At a dose of 10 mg/kg administered orally CBD inhibited LTB4production in mouse blood and was equieffective to the dual lipoxygenase/cyclo‐oxygenase inhibitor BW755C and the lipoxygenase inhibitor BWA4C used at a dose of 50 mg/kg. In the same blood samples CBD stimulated TXB2production from between 20 to 30% over a 4 h period. A23187 stimulation of LTB4synthesis in human polymorphonuclear cells was inhibited by CBD and Δ'‐THC in a dose related manner (IC505.4 and 8.2 μm respectively). However, only CBD produced a 100% inhibition of LTB4synthesis. The production of TXB2in these cells was initially stimulated at low doses by CBD but at higher doses TXB2synthesis was inhi

ISSN:0951-418X    

DOI:10.1002/ptr.2650050606

出版商:John Wiley&Sons, Ltd.    

年代:1991

数据来源: WILEY

摘要:

AbstractPassifloraspecies are used in folk medicine as hypnotic and sedative treatments. In this study the hypnotic‐sedative effects and toxicity ofPassiflora eduliswere assessed in rats and mice and in healthy volunteers. It was verified that some samples ofPassiflora edulishad a nonspecific central nervous system depressant effect. Furthermore, hepatobiliary and pancreatic toxicity to animals and humans were detecte

ISSN:0951-418X    

DOI:10.1002/ptr.2650050607

出版商:John Wiley&Sons, Ltd.    

年代:1991

数据来源: WILEY

摘要:

AbstractThe effects of fluid of roots ofUrtica dioicaandUrtica urenson 67 men of over 60 years of age, suffering from prostatic adenoma, were studied. Functional symptoms such as nocturia were alleviated, particularly in less severe cases, and no untoward effects were observed.

ISSN:0951-418X    

DOI:10.1002/ptr.2650050608

出版商:John Wiley&Sons, Ltd.    

年代:1991

数据来源: WILEY

摘要:

AbstractInhibitory effects of 18 condensed tannins and related compounds on reverse transcriptase from an RNA tumour virus were examined in the presence of poly(riboadenylic acid) oligo(deoxythymidylic acid) ((rA)n(dT)12–18) or poly(ribocytidylic acid) oligo(deoxyguanylic acid) ((rC)n(dG)12–18) as a template‐primer. A potent inhibitory effect was found in galloylated monomers and oligomers as well as non‐galloylated tetramer, trimer and two of three dimers. The mode of the inhibition of one of them, procyanidin B‐2, was competitive with regard to the templa

ISSN:0951-418X    

DOI:10.1002/ptr.2650050609

出版商:John Wiley&Sons, Ltd.    

年代:1991

数据来源: WILEY

摘要:

AbstractSeveral extracts and fractions fromCedronella canariensis(L.) have been submitted to analgesic, antipyretic and antiinflammatory tests on rats and mice. The experimental results obtained justified the utilization of this species as an anticatarrh and antiinfluenza agent in Canarian folk medicine. Its acute toxicity turned out to be low as measured in mice.

ISSN:0951-418X    

DOI:10.1002/ptr.2650050610

出版商:John Wiley&Sons, Ltd.    

年代:1991

数据来源: WILEY

摘要:

AbstractThe antidiarrhoeic activity of the bark ofSclerocarya birreawas investigated. The lyophilized decoction demonstrated antidiarrhoeic activity in experimental models of diarrhoea induced by magnesium sulphate and sodium picosulphate. This antidiarrhoeic activity was related to an inhibition of intestinal transit rather than to inhibition of net secretion of fluid and electrolytes provoked by the laxative agents. A condensed tannin was isolated from the crude drug which produced inhibition in intestinal motility, and the monomer of which was identified as procyanidin.

ISSN:0951-418X    

DOI:10.1002/ptr.2650050611

出版商:John Wiley&Sons, Ltd.    

年代:1991

数据来源: WILEY