摘要:

Paneth cell differentiation was investigated in two colorectal carcinomas. Ultrastructural study showed a range of granules and, in one case, fibrillary cytoplasmic inclusions. Similar inclusions in normal Paneth cells have been associated with zinc deficiency. However, there was no clinical evidence of abnormal zinc metabolism in this patient, nor were inclusions seen in adjacent non‐neoplastic Paneth cells. It is speculated that these fibrillary inclusions might reflect an intrinsic zinc‐related metabolic defect in the tumour ce

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1990.tb01063.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

Obsteosarcomas of the tubular bones of the hands and feet are rare tumours and the initial biopsies are frequently misdiagnosed. We report a case of parosteal osteosarcoma arising in the metacarpal of a female patient aged 53 at first presentation. The tumour recurred three times over two decades and eventually metastasized to the lungs. The differential diagnosis includes florid reactive mesenchymal proliferation and bizarre parosteal osteochondromatous proliferations of the tubular bones of the hand.

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1990.tb01064.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

Renal biopsies were taken from 42 patients at seven and 21 days after renal transplantation. Paraffin sections from these specimens were examined immunocytochemically for the presence of platelet microthrombi in glomerular capillaries using the monoclonal antibody Y2/51. Patients were treated by one of four different immunosuppressive regimes, three of which included cyclosporin A, either alone or in combination with steroids and azathioprine. Microthrombi were detected in approximately 30% of biopsies and were much commoner in patients receiving multi‐drug therapy. We conclude that, contrary to previous suggestions, glomerular capillary thromboses are not frequent in patients on cyclosporin A alone. They are found mainly in patients on multiple drug therapy, particularly when steroids are included. The detection of microthrombi is unlikely to be of assistance in the earlier detection of cyclosporin toxicit

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1990.tb01065.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

A rare vascular proliferation found as a skin lesion in patients suffering from the acquired immunodeficiency syndrome and sometimes referred to as epithelioid angiomatsis is believed to be a manifestation of infection by the cat scratch bacillus or a related organism. We describe the histological findings from eight lesions seen in two cases. In all cases the diagnosis could be confirmed by demonstration within the lesions of groups of gram‐negative rod‐shaped organisms staining positively with the Warthin‐Starry stain. This condition needs to be distinguished from a variety of reactive and neoplastic vascular prolifera

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1990.tb01066.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1990.tb01067.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1990.tb01068.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1990.tb01069.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

A case of small cell carcinoma of the rectum in a patient with chronic ulcerative colitis is described. There was no evidence of enteroendocrine cell hyperplasia.

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1990.tb01070.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

A 14‐year‐old girl presented with menorrhagia. The curettage specimen was extensively necrotic but examination of the subsequent hysterotomy specimen established the diagnosis of alveolar soft part sarcoma of the uterus, a very rare site for this uncommon malignant tum

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1990.tb01071.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1990.tb01072.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY