摘要:

The major forms of lung pathology in the perinatal period are reviewed with emphasis on disturbances of growth and maturation. Lung hypoplasia results from impairment in the physiological control of lung growth during the fetal period. It is more common than organogenetic defects which are discussed only briefly. Hyaline membrane disease is now seldom seen in a pure form due to improvements in perinatal care. However, its complications and sequelae such as interstitial emphysema, pneumothorax and bronchopulmonary dysplasia are encountered more frequently. In addition, a wide variety of pathological processes may localize to, or be expressed in, the lung of the newborn, notably asphyxial changes, persistent pulmonary hypertension, haemorrhage and infection

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1987.tb02682.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

The histopathology of eight cases of sporadic ileocaecal tuberculosis is described with particular reference to caecal lymphoid tissue. Adjacent to areas of ulceration in all cases there was an increase in lymphoglandular complexes (LGC) and proliferation of paravascular lymphoid aggregates deeper in the gut wall. Early and fully‐developed granulomas were present in locations comparable to LGC and lymphoid aggregates. Immunocytochemical staining of paraffin sections with monoclonal antibodies UCHL1 (T‐lymphocyte membrane antigen) and LN‐1, LN‐2 and LN‐3 (B‐lymphocyte and Ia antigens) showed that central cells in LGC and lymphoid aggregates stained like follicular centre B‐lymphocytes. Both LGC and lymphoid aggregates had a distinct peripheral rim of cells staining as T‐lymphocytes, but LN‐2 and LN‐3 also stained scattered peripheral cells, some of which were recognizable as interdigitating reticulum cells. Most lymphocytes within and around granulomas stained as T‐lymphocytes. In lymph nodes, granulomas appeared to occur first at the periphery of, and later to efface, cortical follicles. Lymph node compartments showed the expected T‐ and B‐zonation, and lymphocytes associated with granulomas stained as in caecal granulomas. Our observations suggest that LGC are sites of mycobacterial antigen sampling, of T‐lymphocyte and macrophage activation, and of (potential) granuloma formation in ileocaecal tuberculosis. Lymphoid aggregates deeper in the gut wall probably subserve a similar function during extension of the lesion. The location of both LGC and lymphoid aggregates beside lymphatics is suited to the transfer of their cellular constituents throughout the gut

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1987.tb02683.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

Co‐expression of intermediate filaments is being increasingly reported for many human tumours including carcinoma of the lung. However, it is unclear whether such findings are unusual or restricted to a group of highly atypical tumours. In the present study the pattern of co‐expression of intermediate filaments in 94 human lung tumours has been correlated with light and electron microscopical features which are thought to be atypical for particular tumour types. These same aberrant patterns of intermediate filament co‐expression have also been compared with the proliferative rate of these tumours as determined by labelling with the monoclonal antibody Ki67. The results of this study have shown that the aberrant expression of intermediate filaments is not a feature unique to a group of highly unusual tumours but is found throughout the spectrum of lung cancer. The implications of these findings for the use of anti‐intermediate filament antibodies in pulmonary pathology are discussed with suggestions for future directions which might be taken in thi

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1987.tb02684.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

Fifteen cases of anaplastic thyroid carcinoma, including eight cases with a differentiated component, were studied by DNA analysis. All areas of anaplastic carcinoma showed an aneuploid DNA content. The eight cases of anaplastic carcinoma with differentiated component (two follicular carcinomas, two papillary carcinomas, one Hürthle cell carcinoma and three poorly differentiated carcinomas) exhibited aneuploid DNA content in the differentiated area of the tumour. Karyometric parameters allowed a fairly clear separation between giant cell, spindle cell and differentiated components. The results support the hypothesis that patients with aneuploid differentiated carcinoma represent a higher risk group and are probably more prone to developing anaplastic carcinoma

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1987.tb02685.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

The presence of ceruloplasmin in follicular adenomas (15 cases) and thyroid carcinomas (39) and two Hürthle cell tumours was investigated by immunohistochemical methods. Follicular adenomas were all negative whereas Hürthle cell tumours, follicular and papillary carcinomas exhibited various degrees of cytoplasmic positivity for ceruloplasmin. Highly atypical multinucleated cells and incorporated follicular structures observed in anaplastic carcinomas were positively stained; the spindle cell variety of these cancers was always negative for ceruloplasmin. Medullary carcinomas and normal thyroid tissue were constantly unstained. The distribution pattern of ceruloplasmin is the same as that of lactoferrin, a marker recently proposed for the differential diagnosis between follicular adenomas and thyroid carcinomas; these two glycoproteins are structurally relate

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1987.tb02686.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

The monoclonal antibody Ki‐1 reacts with Reed‐Sternberg cells in Hodgkin's disease and with the tumour cells in a minority of large cell non‐Hodgkin's lymphomas. This study describes the results of immunophenotypic and DNA analysis in 30 cases of non‐Hodgkin's lymphoma, all of which expressed the Ki‐1 antigen. The genotypic analysis has been undertaken using both immunoglobulin and T‐cell receptor gene probes. Sixteen cases were shown by this method to be of monoclonal T‐cell origin, six of B‐cell origin, while in eight cases there was no evidence of either T‐ or B‐cell lineage. This confirms previous immunohistological data indicating that non‐Hodgkin's lymphomas which express the Ki‐1 antigen may be of either

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1987.tb02687.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

Previous studies have shown that oestrogen receptor content in breast cancer was correlated with qualitative and also, more strongly, with quantitative nuclear features in tissue sections. However, even with the better reproducible quantitative microscopical assessments, the variance in the correlation with oestrogen receptor was considerable. This might be due to the implicit problems of oestrogen receptor determination with the biochemical assay. Therefore, receptor content was studied using monoclonal antibodies in 50 consecutive invasive ductal breast cancers. Oestrogen receptor status was compared with qualitative features and with the mean and standard deviation of the nuclear area, morphometrically evaluated on immunostained and adjacent haematoxylin and eosin stained sections. In agreement with earlier observations, nearly all tumours with prominent elastosis were oestrogen receptor positive; but a minority of negative cases also showed elastosis. The correlation between the other qualitative features and receptor status was weak. A significant inverse correlation (P<0.001) existed between the receptor status and the mean and standard deviation of the nuclear area. Even with the highly reproducible morphometrical analysis, correlation between nuclear oestrogen receptor content and quantitative nuclear features was relatively weak. This might indicate that receptor status and nuclear morphometric features reflect different biological characteristics of breast cancers.

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1987.tb02688.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

The immunohistochemical and ultrastructural features of a case of pulmonary blastoma in a 39‐year‐old woman are documented. Three types of cells were observed: epithelial, mesenchymal and ‘blastomatous'. The latter stained with intermediate filament antibodies similar to those of mesenchymal and epithelial elements, thus supporting the hypothesis that this tumour is derived from a pluripotent undifferentiated el

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1987.tb02689.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1987.tb02690.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

Book reviewed in this article:Atlas of ImmunohistologyEdited by R.R. Tubbs, R.E. Petras&G.N. Gephardt. Raven Press, New York, 1986, 200 pages, £109.00Aspects of HypoxiaEdited by D. Heath. Liverpool University Press, Liverpool, 1986, 288 pages, £28.00New Concepts in Neoplasia as applied to Diagnostic PathologyEdited by C.M. Fenoglio‐Preiser, R.S. Weinstein&N. Kaufman. Williams&Wilkins, Baltimore, 1986, 292 pages, £

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1987.tb02691.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY