摘要:

Twenty‐five cases originally diagnosed as malignant histiocytosis/true histiocytic lymphoma were reviewed according to both pathological and clinical criteria. Microscopically, they were characterized by large, pleomorphic tumour cells showing variable degrees of atypia and phagocytic activity. The growth more often appeared as diffuse, being limited to the sinuses in only two cases. Cytochemistry on touch imprints showed tumour cells strongly positive for acid phosphatase and α‐naphthyl‐acetate esterase in all the samples tested. Immunohistochemistry on paraffin embedded sections using specific antisera showed tumour cell positivity for lysozyme in 12 of 25 cases, for α1‐antitrypsin in 24 of 25 cases and for α1‐antichymotrypsin in all 25 cases. Immunophenotyping on frozen‐sections in three cases displayed a clear‐cut reactivity of the neoplastic cells with the monoclonal antibody OKM1. Clinically, the disease more often presented with B‐symptoms, lymphadenopathy and mediastinal involvement. In the majority of the patients (18/25) it had a fatal and rapid course, despite therapy (median survival: 9 months; mean survival: 12 months). The presence of B‐symptoms and bulky disease appeared as the only factors influencing the prognosis, both suggesting a more aggressive

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02877.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

Forty‐one cases of dermatofibrosarcoma protuberans are presented. The clinical features and histopathological appearances are described. Immunohistochemical staining of thirteen cases with antisera to lysozyme, α1‐antichymotrypsin and S‐100 protein has provided no evidence to support either a histiocytic or neuroectodermal origin for these tumours. In reviewing the literature, the histogenetic origin, differential diagnosis and malignant potential of dermatofibrosarcoma protuberans are dis

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02878.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

Pretreatment bone marrow trephine biopsy sections (BMB) from 34 patients with acute myeloid leukaemia (AML) were studied in parallel with bone marrow aspiration smears and peripheral blood films. In four cases marrow aspiration was inadequate and in five cases it was unsatisfactory. In two other cases hypoplastic AML was diagnosed, the aspirate in one suggested hypercellularity and in another it was unsatisfactory. Trephine biopsy was superior to aspiration for the evaluation of fat and marrow cellularity, pattern and extent of blast cell infiltration, homogeneity of the leukaemic infiltrate, frequency of mitoses, residual haemopoietic activity and presence of inflammatory cells. Of the various features studied in the sections, the presence of an increased number of plasma cells and considerable myelodysplasia (MD) appeared to be unfavourable prognostic features. We conclude that trephine biopsies are essential for the diagnosis of hypoplastic AML and are most useful when marrow aspiration is either inadequate or unsatisfactory. They also provide additional information about the bone marrow changes in AML and suggest that some histological features may also have prognostic significance.

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02879.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

The controversies that exist amongst patlologists about ischaemic heart disease result in part from the widespread use of non‐quantifiable techniques in examining the coronary artery tree. Such techniques are used because it is believed that there is no alternative method which does not involve an inordinate expenditure of time, money and effort. This paper describes procedures involving post‐mortem coronary angiography which may be used alone or in combination with histological examination to give an immediate, accurate and permanent record of coronary artery disease or allow a far more detailed quantitative investigation of coronary vasculat

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02880.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

A case in which both malignant histiocytosis and T‐cell lymphocytic lymphoma occurred together is presented. Examples of malignant histiocytosis‐like syndromes associated with lymphoreticular malignancies, have been previously reported. Many of these represent reactive haemophagocytic syndromes, probably virally induced. The considerable degree of cytological atypia and frequent mitotic figures seen in the histiocytes in this case were indicative of a true malignant histiocyto

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02881.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

We report a case of polypoid spindle cell squamous carcinoma (pseudosarcoma) occurring in the anal canal. Electron microscopic findings and the demonstration of keratin by an immunoperoxidase method, gave clear cut evidence of the epithelial nature of the saicomatoid cells forming this tumour. To our knowledge, this is the first reported case in the literature.

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02882.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

We report a patient with a long history of pan‐hypopituitarism treated with pituitary snuff who developed superior mediastinal fibrosis involving the visceral pericardium, retroperitoneal fibrosis, and a peculiar widespread nodular fibrosis of the lung

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02883.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

We describe an unusual case of Caroli's disease in which the disease was confined to the left hepatic lobe, was accompanied by biliary papillomatosis and associated with intrahepatic pancreatic heterotopia.

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02884.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02885.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

Book reviewed in this article:H.Fox. W.B.Saunders, EastbourneJ.W.A. J.Reeders, G.N.J.Tytgat, G.Rosenbush&S.Gratama. Martinus Nijhoff Publishers, Boston, The Hague, Dordrecht, LancasterR.Valenzuela, W.F.Bergfeld&S.D.Deodhar, American Society of Clinical Pathologists, distributed by Raven Press, New York

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02886.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY