摘要:

This review aims to provide a simple guide and quick reference to the terminology and diagnostic applications of leucocyte monoclonal antibodies. The differentiation cluster terminology, where applicable, is used throughout.

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1988.tb01967.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Autopsy pancreases were studied from 14 patients who had idiopathic Addison's disease. One patient had been diabetic for 12 years and three patients were found to be diabetic during their terminal admission. While there was no evidence of diabetes or destruction of insulin‐secreting beta cells in the remaining 10 patients, islets in one pancreas exhibited many of the histological and immunohistochemical features seen in the patients with recent onset diabetes. These included the presence of alpha‐interferon in endocrine cells, hyper‐expression of class I major histocompatibility complex molecules by endocrine cells in islets where alpha‐interferon was also present, aberrant expression of class II major histocompatibility complex molecules by endocrine cells and the presence of insulitis. Since the combination of these changes has only been described in type 1 diabetes it is thought that the appearances seen in this pancreas were those of pred

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1988.tb01968.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

In a retrospective study comprising 216 germ‐cell tumours occurring in children from birth to the age of 18 years, 27 immature teratomas were found at a variety of sites. Seventeen of these were curatively treated by means of one operation. Only two patients died as a direct result of tumour growth. Recurrences and metastases often proved to be treatable. In ovarian tumours grading was of considerable prognostic importance. The term malignant teratoma, which is sometimes used to describe these tumours, is confusing and should be avoide

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1988.tb01969.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

One hundred and two cases of poorly differentiated adenocarcinoma were obtained from 71 surgical and 31 biopsy specimens of the stomach. These tumours produced both intracellular and extracellular mucins, which were demonstrated to be neutral mucins, N‐acetyl sialomucins, sulphomucins and O‐acetyl sialomucins. The majority of tumours (85.3%) secreted two or more kinds of mucins simultaneously, but only a small proportion (14.7%) produced a single kind of mucin. Ultrastructurally, three types of mucin granules were identified; these differed in shape and density. Tumour cells containing intracellular mucins or mucin granules were designated as mucous cancer cells and further subdivided into small, large and goblet mucous cells; tumour cells having neither mucins nor glandular differentiation were designated as undifferentiated cancer cells. These histochemical distinctions, supported by the electron microscopical observations, may be useful to demonstrate early malignant foci in gastric biops

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1988.tb01970.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Dedifferentiated chondrosarcoma is a biphasic tumour, comprising well‐differentiated chondrosarcoma and an anaplastic non‐cartilaginous sarcoma juxtaposed but distinct from each other. Two cases of dedifferentiated chondrosarcoma, one primary and one recurrent, demonstrated muscle differentiation when studied with monoclonal antibodies to muscle specific actin, desmin and myoglobin. One of the tumours was also positive for cytokeratin, identified by AE1/AE3 and CAM 5.2 antibodies. Our findings are consistent with the concept that these tumours are capable of diverse patterns of morphological and immunophenotypic differentiat

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1988.tb01971.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

A mucinous cystadenoma of the mesentery and two borderline mucinous cystadenocarcinomas of the mesentery and retroperitoneum are reported. The patients were females, aged 38, 47 and 58 years. The cysts showed identical features to those commonly seen in the appendix and ovary. One of our cases, with ‘borderline’ histology, developed metastases to mediastinal lymph nodes, 4 years after diagnosis. We suggest that these tumours develop through mucinous metaplasia in pre‐existing mesothelium‐lined cysts, the latter being the commonest cysts in this l

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1988.tb01972.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Two patients with chronic intestinal pseudo‐obstruction are reported, one of whom had definite systemic sclerosis while the other had certain manifestations of the disease. Biopsies of the small intestine revealed increased collagen and elastic fibres in the muscularis propria and subserosa in each case, while ganglion cells were normal. In addition, one patient had severe atrophy of the inner muscle layer and the other obvious vacuolation of the muscularis propria. Ultrastructural examination confirmed degeneration of the smooth muscle fibres. These latter features have been considered the hallmark of visceral myopathy and their finding in this patient therefore suggests that the different causes of pseudo‐obstruction may not be completely demarcated and cases in which the features overlap may oc

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1988.tb01973.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

A male infant was diagnosed as having diabetes mellitus 1d after birth and died on the third day. Histological examination of the pancreas showed small and inconspicuous islets of Langerhans that were completely devoid of insulin‐secreting cells. There was no evidence of insuliti

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1988.tb01974.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1988.tb01975.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

A solitary malignant schwannoma with glandular differentiation occurred in the forearm of a 54‐year‐old man. The patient displayed no stigmata of von Recklinghausen's neurofibromatosis. He did well after conservative surgery and there are no signs of recurrence 5 years after operation. The rarity of the tumour and the unusually long survival are points of interest. The histogenesis of the glandular component is discus

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1988.tb01976.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY