摘要:

This review summarizes the clinicopathological features of a number of vascular tumours that have been characterized only in recent years. These include: glomeruloid haemangioma. a multifocal vascular lesion associated with POEMS syndrome; Kaposi‐like infantile haemangioendothelioma, a borderline malignant tumour occurring in the retroperitoneum of infants, mimicking Kaposi's sarcoma histologically; giant cell angioblastoma, characterized by proliferated vessels with a granuloma‐like appearance; benign lymphangioendothelioma (progressive lymphan‐gioma), a slowly‐growing macule or plaque over the trunk or limb, mimicking low‐grade angiosarcoma histologically; largetoid haemosiderotic haemangioma. a benign lesion with a distinctive annular appearance and histologically overlapping with benign lymphangioendothelioma; spindle cell haemangioendothelioma, a lesion located mostly in the distal extremities, characterized by cavernous vascular spaces, spindle cells with interspersed narrow vascular channels and scattered plump vacuolated endothelial cells; acquired tufted angioma. characterized by ‘cannon‐ball’; involve aent of the dermis by lobules of pericyte‐rich capillaries: sinusoidal haemangioma, a distinctive variant of cavernous haemangioma which may be confused with angiosarcoma; and epithelioid angiosarcoma, a highly aggressive tumour of deep soft tissue mimicking metastatic carcinoma and co‐expressing endothelial and

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1991.tb01497.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

Plexiform fibrohistiocytic tumour is a recently described, seemingly benign neoplasm of superficial soft tissue which is poorly recognized and the differentiation pattern of which remains obscure. Fourteen new cases are presented here. These presented predominantly in the upper limb of infants and children, although the age‐range was wide. A morphological spectrum depending on the relative proportions of the spindle cellular and nodular histiocyte‐like components was evident. Immunohistochemical analysis revealed positivity of tumour cells in both components for smooth muscle actin. suggestive of myofibroblastic differentiation, as was borne out ultrastructurally in two cases. In addition, a minority of the histiocyte‐like cells were also CD68 positive but negative for leucocyte common antigen. HLA‐DR, Mac387 and lysozyme. In view of the ultrastructural and other immunohistochemical results, this is regarded as further evidence that the CD68 epitope recognized by KP‐1 is not confined to cells of monocyte/ macrophage or myeloid lineage. Plexiform fibrohistiocytic tumour appears to be a clinicopathologically distinctive myofibroblastic neoplasm which may warrant reclassification in d

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1991.tb01498.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

Solitary fibrous tumours (‘pleural fibromas’) are well‐recognized in the pleura, but their rare occurrence at other sites has only become appreciated in recent years, as a consequence of which extrapleural examples often go unrecognized or misdiagnosed. Eight cases (three peritoneal, two retroperitoneal. two intrapulmonary and one mediastinal) are presented herein. All but one presented in adulthood, and three were asymptomatic chance findings. Size ranged from 0.8 to 26 cm in maximum diameter. To date, none has behaved in an aggressive fashion. Histologically, these lesions are entirely comparable to their pleural counterparts, and accurate diagnosis is largely dependent on appreciation of their potential extrapleural location. Immunohistochemistry in seven cases favoured myofibroblastic fibroblastic differentiation, in keeping with the putative submesothelial origin of these le

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1991.tb01499.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

The inducible adhesion molecules mediate important functions in the lymphoid tissues. We have investigated the expression of intercellular adhesion molecule 1 (ICAM‐1), endothelial leucocyte adhesion molecule 1 (ELAM‐1), vascular cell adhesion molecule 1 (VCAM‐1), and platelet endothelial cell adhesion molecule (PECAM/CD31), using immunocytochemistry on cryostat sections of five lymph nodes from patients with Castleman's disease of the hyaline‐ vascular type. All five cases were characterized by marked hyperplasia of follicular dendritic reticulum cells, which were extensively present even in the mantle zone. Hyperplastic follicular dendritic reticulum cells showed marked expression of VCAM‐1, and weak expression of ICAM‐1. In two cases, several dysplastic giant cells with aberrant, polyploid nuclei showed aberrant expression of ELAM‐1, an endothelium‐restricted molecule. Dysplastic giant cells were positive with DRC‐1 (an antibody to dendritic reticulum cells). VCAM‐1 and occasionally ICAM‐1, were negative for the endothelial cell markers factor VIII‐related antigen and CD31 and were non‐proliferating (Ki‐67‐). Cells positive for ICAM‐1 or VCAM‐1 were rare in the interfollicular areas. In all cases vascular hyperplasia was prominent, but endothelial cells were poorly activated in terms of expression of inducible adhesion molecules and of HLA‐DR antigens. The possibility that dysplastic follicular dendritic reticulum cells have a pathogenetic role

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1991.tb01500.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

The light microscopic and polarization appearances of calcium pyrophosphate dihydrate crystal deposits in tissues are reviewed. In routine sections haematoxylinophilic crystalline deposits with a feathery or brush‐like pattern are typical of calcium pyrophosphate dihydrate. Short rhomboidal crystals showing positive birefringence are seen on polarizaition; X‐ray microanalytical and infrared spectroscopic data support the specificity of these appearances. The appcai ances of the crystal deposits in decalcified specimens are also described. We include six cases of calcium pyrophosphate dihydrate deposition within periarticular bone; to the best of our knowledge this has not previously been descri

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1991.tb01501.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

Observations differ on the pre‐invasive malignant lesions associated with the various categories of testicular germ cell tumours. Such lesions have been found to be similar in appearance and are assumed to be composed of multipotent cells, or conversely a distinctive pre‐invasive stage has been reported in association with each form of germ cell neoplasm. This study was undertaken to see whether distinctive morphological and immunohistochemical features of carcinoma in situ adjacent to various categories of germ cell tumours could be established. Carcinoma in situ adjacent to seminomas, teratomas and mixed germ cell tumours in 18 adults was indistinguishable morphologically. Placental alkaline phosphatase was demonstrated immunohistochemically but vimentin and low molecular weight cytokeratins were uniformly absent in these abnormal germ cells from all three groups. These findings support the concept of a multipotent pre‐invasive malignant cell for both seminoma and teratoma in the adult. Carcinoma in situ was not seen adjacent to 1 5 spermatocytic seminomas, nor was placental alkaline phosphatase demonstrated in tubules adjacent to these tumours. These negative findings are additional evidence that spermatocytic seminoma differs from classical seminoma in its histogenesis. Carcinoma in situ, as defined morphologically and immunohistochemically in adults, was not identified adjacent to yolk sac tumours and differentiated teratomas in 20 prepubertal testes. The possibility that pre‐invasive malignancy in children may not resemble that in adults must be considered when assessing the malignant potential of cryptorchid testes on biopsies taken during orch

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1991.tb01502.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

One hundred and eighty‐seven operable lung tumours were immunostained with the monoclonal antibody Ki‐67 and divided into groups of high, moderate or low proliferation. Patients have been followed clinically for up to 7 years to ascertain whether this immunocytochemical measurement reflected tumour behaviour in terms of survival. The majority of the tumours were squamous cell carcinomas (104 cases) and adenocarcinomas (60 cases). These were divided into three groups of low, intermediate and high growth fraction, in which survival was better for tumours of lower proliferative rate up to approximately 2 years after operation. By 5 years these differences had largely disappeared and all tumours of a particular type showed a similar survival curve. Small cell carcinomas (13 cases) had high Ki‐67 labelling indices, with more than 60% of patients dead in the first year, whereas carcinoid tumours (10 cases) had low labelling rates and all but one are still alive. We conclude that measurement of lung tumour growth rate with the monoclonal antibody Ki‐67 shows promise as a possible indicator of short‐term survival and perhaps as a means of choosing a group of patients with adenocarcinomas and squamous cell carcinomas for post‐operative c

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1991.tb01503.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

In a study of 40 patients with high‐grade (G2 and G3) transitional cell carcinoma of bladder invading the lamina propria—stage pT1, retraction artifact was often misdiagnosed as vascular/lymphatic tumour invasion. Vascular/lymphatic infiltration was diagnosed in five cases based on haematoxylin and eosin stained sections, but confirmed in only two of these using immunohistochemical techniques to demonstrate endothelial markers. Of the latter, these preparations demonstrating von‐Willebrand factor and binding the monoclonal antibody QBEND/10 were technically superior to those in whichUlex europaeusagglutinin 1 was used. It is unlikely that the demonstration of vascular/lymphatic infiltration, a rare feature, will prove of value in defining prognostic groups for trea

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1991.tb01504.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1991.tb01505.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1991.tb01506.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY