摘要:

The morphological features of 32 cases of malignant lymphomas involving the central nervous system presenting over a 32 year period were reviewed and the lymphomas redefined using current classifications. Twenty‐four cases (75%) of non‐Hodgkin's lymphomas were reclassified using the Kiel classification. There were 18 low grade non‐Hodgkin's lymphomas (comprising 11 lymphoplasmacytoid, five lymphocytic and two centroblastic‐centrocytic) and six high grade tumours (comprising two centroblastic, two immunoblastic, one unclassifiable and one lymphoblastic lymphoma). Cytologically the great majority of non‐Hodgkin's lymphomas were B‐cell lymphomas. The eight cases (25%) of Hodgkin's disease were classified by the Rye subtype and consisted of three mixed cellularity, two lymphocyte depletion, two lymphocyte predominant and one nodular sclerosis. The presence of intracytoplasmic immunoglobulins as well as markers for histiocytic cells were studied by the immunoperoxidase technique using polyclonal antisera. A monoclonal staining pattern, as revealed by light chain restriction, was found in nine cases (38%) of the non‐Hodgkin's lymphomas confirming their B‐cell origin. With the Marshall's metalophil method and the other histiocytic markers, scattered reactive microglial cells and histiocytic reticulum cells were found throughout the tumours in most cases. No histiocytic lymphomas were presen

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1987.tb02639.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

Tissue specimens of neural crest‐derived structures like normal spinal and sympathetic ganglia and adrenals of adults, infants and fetuses were used as immunohistochemical test substrates for a panel of 10 monoclonal antibodies to neuroblastoma cells raised by immunization with a variety of immunogens (fetal brain, neuroblastoma cell lineages, chick retinal cells or purified Thy‐1 antigen). Antigen expression varied among normal structures such as ganglion cells, satellite cells, various nerve fibres, and different cells in the adrenal cortex. This variability in immunoreactivity shown by different cell types and structures was comparable to that seen when the same panel of moncclonal antibodies was applied to neuroblastomas and to ganglioneuroblastomas of different degrees of maturation and differentiation. The neoplasms thus seemed to reflect the normal maturation in the neuroectodermally‐derived structures. Also, the studies give indications as to the cell of origin of the undifferentiated neuroblas

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1987.tb02640.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

A panel of monoclonal antibodies to neuroblastoma cells, leucocyte common antigen, vimentin and MHC class II antigens (HLA‐DR) and a polyclonal antibody to epidermal keratin were used for immunohistochemistry on sections of ethanol fixed and paraffin embedded specimens from 40 undifferentiated small cell tumours and 10 neural crest neoplasms. With the exception of central nervous system neoplasms and two embryonal rhabdomyosarcomas, immunohistochemical examination discriminated between the neural crest neoplasms and the other small cell tumours. Moreover, the staining pattern of neoplastic cells and structures in the neural crest neoplasms obtained with antibodies to neuroblastoma cells seemed, in part, to reflect the degree of tumour differentiatio

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1987.tb02641.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

Immunohistochemistry was used to examine 10 cases of malignant fibrous histiocytoma. Malignant cells in all cases expressed vimentin and in eight there was co‐expression of either desmin or neurofilament, both of these being present in four cases. In addition, cytokeratin was found in one case. In each tumour, a population of small cells was identified which had the staining characteristics of benign macrophages, and this was distinct from the tumour cells. This study supports the concept that malignant fibrous histiocytoma is a tumour of mesenchymal cells rather than of histiocytes and emphasizes the diversity of its cytostructur

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1987.tb02642.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

In a preliminary study, we assessed 10 lectins for the identification of dysplasia in colectomy specimens from patients with ulcerative colitis. Peanut agglutinin (PNA) binding was found in all cases of dysplasia. In the main study the relationship between PNA staining, high iron‐diamine/alcian blue (HID‐AB) histochemistry, and dysplasia was investigated in 115 pre‐operative colonoscopic biopsies and the subsequent resection specimens from patients with ulcerative colitis complicated by carcinoma (n=6) and patients undergoing proctocolectomy for failure of medical management (n=8). Peanut lectin was of no value in the assessment of pre‐malignant changes or cancer risk. However, the HID‐AB stain appears to clarify the interpretation of less severe pre‐malignant changes and may be usefully applied to the interpretation of colonoscopic biopsies for cancer surveillance in ulcerat

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1987.tb02643.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

An uncommon form of presentation of melanocytic dysplasia is described in 15 patients with primary cutaneous melanoma and a high incidence of multiple melanomas. This variation in melanocytic dysplasia appears macroscopically to the pathologist and to the clinician as a diffuse mottling or ‘freckling’of the widely excised skin around the melanomas. Most patients also were described clinically as having multiple moles in other sites as well as round the melanoma. Histologically, the abnormally pigmented skin of the wider excisions has the features of melanocytic dysplasia, usually of lentiginous type, and this is seen both in continuity with the melanoma and distant from it including the margins of the wider excisions. These patients seem particularly prone to developing additional primary melanomas and therefore recognition of this form of presentation of melanocytic dysplasia may be important in patient management and prophylactic care of their famil

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1987.tb02644.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

Two cases of pedunculated hepatocellular carcinoma are reported. One of these was known to have been present for 5 years. Both patients are alive 1 and 2 years after surgery though the former has developed a solitary bone metastasis. The literature on 30 previously published cases is reviewed and it is concluded that, minor differences apart, this tumour is not substantially different from hepatocellular carcinomas in general. The slow growth and good prognosis relate to its extrahepatic location which may be explained by an origin from accessory lobes of the liver.

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1987.tb02645.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

We report the fourth case of an osteoclastoma‐like giant cell tumour of the renal pelvis. A special feature was that although thorough sampling of the tumour showed an osteoclastoma‐like pattern throughout, it was intimately associated with carcinomain situchange of the adjacent transitional epithelium and this provides further support for the view that these tumours are of epithelial derivation. However, immunohistological and ultrastructural studies failed to reveal epithelial features within the tumour cells and the possible significance of this finding is discus

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1987.tb02646.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

A case of a primary sarcomatous tumour in the liver of an elderly female is reported. The tumour consisted of bundles of spindle cells focally in a storiform pattern, intermingled with bizarre giant cells. Immunocytochemically, carcinoembryonic antigen, alpha‐fetoprotein, keratin, desmin and type IV collagen could not be demonstrated. Most tumour cells, however, expressed vimentin, whereas a granular cytoplasmic immunoreactivity for alpha‐1‐antitrypsin and alpha‐1‐antichymotrypsin was shown in the giant cells. Ultrastructurally the tumour cells did not show any characteristics of epithelial derivation. The morphological and immunocytochemical data justify the conclusion that the tumour should be classified as a malignant fibrous his

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1987.tb02647.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1987.tb02648.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY