摘要:

The clinical, morphological and immunohistochemical features of 15 cases of pulmonary lymphoproliferative disease are described. The diagnosis of primary pulmonary lymphoma was based in 13 cases on the demonstration of light chain restriction and in two cases on morphological characteristics. Many patients had a prolonged clinical course without significant clinical or radiographic deterioration, a feature associated with malignant lymphomas of mucosa‐associated lymphoid tissue in other sites. Lympho‐epithelial lesions were characteristic and malignant cells had the features of centrocyte‐like cells, similar to those described in gastric and salivary gland lymphomas. Germinal centres were present in three cases: some were partially overgrown by centrocyte‐like cells but residual polyclonal follicle centre cells and dendritic reticulum cells were still detectable. It is suggested that primary pulmonary lymphoma arises from centrocyte‐like cells normally present in bronchus‐associated lymphoid tissue. In addition to the malignant population, reactive follicles and polytypic plasma cells are frequently present and may prejudice interpretation of immunohistochemical features. In the light of these findings, cases previously diagnosed as pseudolymphoma or lymphoid interstitial pneumonia require careful assessment and the majority are, in reality, examples of primary pulmonar

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1988.tb02000.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

The histology, immunophenotype and clinical presentation of 43 cases of T‐cell lymphoma are described. Cases were classified into nine types; T‐lymphocytic lymphoma (three), mycosis fungoides (six), Sézary syndrome (two), T‐zone lymphoma (13), angio‐immunoblastic lymphadenopathy (AIL)‐like T‐cell lymphoma (five), pleomorphic medium cell (one), large cell immunoblastic (four), large cell polylobated (five) and lymphoblastic (four). The patients comprised 26 males and 17 females aged between 15 and 86 years. The majority showed disseminated disease at the time of diagnosis (18 stage IV, nine stage III, five stage II, eight stage I and three cases not staged). Thirty‐one patients showed lymph node involvement. Cutaneous involvement was a common finding (18 cases, 10 cases excluding mycosis fungoides and Sézary syndrome). Details of therapy and clinical follow‐up were obtained in 37 cases. With simple chemotherapy only one complete response (7%, 1/16) was obtained. With aggressive therapy 48% (13/27) of patients showed complete responses. Twenty patients died during the follow‐up period. Life table analysis showed a 58% probability of surviving 1 year and 36% probability of surviving 3 years. There was a significant difference in survival probability between low/intermediate‐grade (lymphocytic, Sézary syndrome, mycosis fungoides and T‐zone lymphoma including AIL‐type) lymphomas and high‐grade (large cell immunoblastic and polylobated and lymphoblastic) lymphomas (P<0.025). However, when survival of T‐zone and AIL‐like T‐cell lymphoma was compared with survival of large cell immunoblastic and polylobated lymphomas no significant difference was detected. Age (<50 years) and stage I or II disease were associated with significantly b

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1988.tb02001.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

A series of 47 primary and seven metastatic thyroid follicular carcinomas, including well, moderately and poorly differentiated, were tested for thyroglobulin (Tg) using immunohistology. In addition, three combined follicular undifferentiated carcinomas, 17 undifferentiated carcinomas and five renal cell carcinomas metastatic to the thyroid were examined. Only two follicular carcinomas did not stain for thyroglobulin. Some inter‐tumour differences in Tg staining were found but there was no absolute correlation between this and the degree of tumour differentiation. The two tumours that failed to stain for Tg were poorly differentiated; thyroglobulin positive poorly differentiated tumours demonstrated a clearly weaker staining pattern for Tg. All but one of 15 oxyphilic follicular carcinomas stained positively for Tg but the staining intensity was often weak. Five of six clear cell follicular carcinomas were positive for Tg but the staining reaction was generally faint and there were often large areas devoid of positive cells. Positive staining was demonstrated in the differentiated areas of combined follicular undifferentiated carcinomas. Undifferentiated carcinomas and metastatic renal cell carcinomas gave negative results. Thyroglobulin is a reliable marker for thyroid follicular carcinoma but the patchy staining pattern, particularly in the less well‐differentiated tumours, may produce less reliable results in small biops

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1988.tb02002.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

We have studied mucosubstances in 12 cases of medullary carcinoma of the thyroid using histochemical techniques and a number of different lectins. Immunohistochemical staining for calcitonin and carcinoembryonic antigen was also performed. We have found that the presence of mucosubstances is a constant finding in medullary carcinomas; they were present extracellularly in 100% of cases and intracellularly in 53.3%. In both these compartments there was a predominance of neutral over acid mucosubstances. Receptors for UEA‐I, Con A, RCA‐I, Succ‐WGA and SBA were found in many cells in the majority of cases, but there were differences in the affinity from one case to another. Because of this lack of specificity lectin histochemistry is not of diagnostic value in medullary carcinomas of the thyroid. The possible relationships of the lectin‐binding results to glycosylated hormone precursors and carcinoembryonic antigen are di

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1988.tb02003.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

The occurrence and localization of IgA and secretory component (SC) were examined in the normal and in adenocarcinomas of Fallopian tube, endometrium and endocervix. IgA‐containing immunocytes were identified in the stroma of 90% of normal Fallopian tubes. It is suggested that the Fallopian tube may have an immunological function and may, together with the endocervix, constitute the local secretory immune system of the female genital tract. IgA and SC were frequently demonstrated in the cytoplasm and luminal secretion of adenocarcinomas of the endocervix, endometrium and Fallopian tube. This study has shown a decrease in immunoreactivity of SC among poorly differentiated adenocarcinomas but has failed to demonstrate any correlation between the expression of IgA and the degree of differentiation of the tumours. Secretory component appears, therefore, to be more useful than IgA as an indicator of secretory activity and differentiation of adenocarcinomas of the female genital trac

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1988.tb02004.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Antisera to α1‐antichymotrypsin, α1‐antitrypsin and lysozyme were reacted with 20 cases of glioblastoma multiforme, seven anaplastic astrocytomas, eight astrocytomas, six oligodendrogliomas, four ependymomas and the cerebral cortex from six normal autopsy brains. In addition, two pleomorphic xantho‐astrocytomas and two heavily lipidized malignant gliomas were similarly examined. All astrocytic lesions were confirmed with anti‐GFAP antisera. Thirty astrocytic tumours (77%), four oligodendrogliomas (67%) and three ependymomas (75%) reacted positively with anti‐α1‐antichymotrypsin; 25 astrocytic tumours (64%), three oligodendrogliomas (50%) and three ependymomas (75%) showed positive staining for α1‐antitrypsin. The pattern of staining with either of these two markers did not correlate with tumour grading. None of the gliomas examined stained positively with anti‐lysozyme. Non‐neoplastic glial elements did not react with any of the three antisera. The results of this study suggest that staining for α1‐antichymotrypsin and α1‐antitrypsin is of little value in the differential diagnosis of neuroepithelial or mesen

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1988.tb02005.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

The histopathological appearance of proliferative squamous lesions removed from the skin of iatrogenically immunosuppressed patients differs subtly from that of classical malignant and premalignant epidermal lesions. The majority of cases show ‘Bowenoid’ changes with a marked degree of cellular atypia including characteristic multinucleate ce

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1988.tb02006.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Using silver (Ag) staining to demonstrate nucleolar organizer region‐associated proteins (AgNORs), pigmented naevi exhibiting features of melanocytic dysplasia have been examined and compared with benign intradermal and compound naevi and with malignant melanomas. A highly significant difference was found between the numbers of AgNORs demonstrated in benign naevus cells and atypical melanocytes and in malignant melanocytes, suggesting that this technique may have a role in differentiating between difficult melanocytic lesion

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1988.tb02007.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Two cases of alveolar soft part sarcoma have been studied immunocytochemically using antisera against epithelial membrane antigen, lysozyme, keratins, S‐100 protein, desmin, vimentin, fetal myosin, slow myosin, alpha‐skeletal muscle actin, alpha‐smooth muscle actin and myoglobin. The neoplastic cells were negative with all antisera employed with the exception of the alpha‐skeletal muscle actin antiserum which stained the cytoplasm of numerous neoplastic elements, including the crystalloid rods, typical cytoplasmic inclusions of these tumours. It is suggested that the presence of this protein indicates rhabdomyoblastic differentiation of these

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1988.tb02008.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

The first case of a keratinizing squamous cell carcinoma of the uterine cervix with differentiation toward dermal adnexal structures is reported. A review of skin‐associated structures in the non‐neoplastic uterine cervix is given and the histogenesis discussed. Recent literature dealing with extracutaneous neoplasms with sebaceous differentiation is ci

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1988.tb02009.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY