ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1983.tb02260.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

Using the sensitive peroxidase, anti‐peroxidase immunohistological technique, carcinoembryonic antigen (CEA) was studied in formalin‐fixed, paraffin‐embedded cervical specimens from 225 patients. CEA was demonstrated in 33% of moderate dysplasia, 78.5% of severe dysplasia, 79% of in‐situ carcinoma and 78% of invasive carcinoma. CEA was not demonstrated in normal squamous epithelium, squamous metaplasia, reserve cell hyperplasia nor in mild dy

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1983.tb02261.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

In a semi‐quantitative necropsy study, total anomalous pulmonary venous connection (TAPVC) was an isolated anomaly in 35 cases and was associated with asplenia and either pulmonary stenosis or pulmonary atresia in 22 cases. A comparison of the two groups showed pulmonary venous obstruction (26% vs. 4%), a small interatrial communication (51% vs. 4%), a patent ductus arteriosus or operative shunt (40% vs. 64%), medial hypertrophy of muscular pulmonary arteries (80 vs. 23%), muscularization of arterioles (80% vs. 23%), capillary engorgement (60% vs. 27%) alveolar wall thickening (29% vs. 0%), interlobular septal oedema (34% vs. 14%), dilated lymphatics (80% vs. 45%), arterialization of pulmonary veins (86% vs. 68%), medial hypertrophy of veins (26% vs. 0%), and venous dilatation (74% vs. 50%). Only one patient, a 5‐year‐old girl with isolated TAPVC, had severe plexogenic pulmonary arteriopathy. In the remainder, the pulmonary lesions were those generally associated with reversible pulmonary venous hypertension; they were most striking in patients with pulmonary venous obstruction, and were least prominent in patients with pulmonary stenosis or puimonary at

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1983.tb02262.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

We studied 116 benign and 18 borderline malignant mucinous ovarian cystadenomas. Their epithelial lining was compared with normal epithelium of the uterine cervix and that of the small and large intestines, by both light and electron microscopy as well as histochemically. This morphological and histochemical analysis enabled us to subdivide mucinous cystadenomas into cervical, mixed and intestinal epithelial types. The epithelial cells of intestinal type tumours exhibited histochemical reactions very similar to, or identical with, those found in both immature and mature cells of intestinal mucosa. Malignant transformation was found in intestinal type mucinous cystadenomas only. Ultrastructural investigations of six neoplasms (four of intestinal and two of cervical epithelium type) confirmed the results found with the light microscope.

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1983.tb02263.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

Pleomorphic lipoma or giant‐cell lipoma is a recently recognized entity affecting predominantly elderly and middle‐aged men. The neck, shoulder region and back are the sites of predilection. The clinical setting is similar to that seen with spindlecell lipoma. The lesion is characterized by an intricate mixture of mature fibrous tissue, adipose tissue and myxoid tissue interspersed with cellular foci. Most characteristic of the latter are a variety of giant cells and especially the ‘floret’ giant‐cells, so named because of the arrangement of their nuclei which is reminiscent of the petals of a flower. The pleomorphism of the lesion frequently leads to misdiagnosis as liposarcoma. Criteria for the differentiation from the various types of liposarcoma are discussed. The possible relationship of pleomorphic lipoma to some of the ‘atypical lipomas’ described in the recent literature is analysed. The pleomorphic lipoma is a benign lesion of subcutaneous tissue which must be sharply differentiated from sarcomas. Some of the liposarcomas alleged in the literature to have originated within a pre‐existing lipoma possibly represented pleomorphic lipomas. Pleomorphic lipoma is an entity which must be added to the growing number of pseudosarcomatous lesions

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1983.tb02264.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

A histological review of 1003 invasive breast carcinomas identified 51 tumours in which the invasive component showed a predominantly cribriform pattern. These separated into two groups; 35 which showed exclusively cribriform or cribriform with a limited extent of tubular invasive elements only, designated ‘classical’ invasive cribriform carcinoma and 16 which also contained areas of less well differentiated invasive carcinoma, designated ‘mixed’ invasive cribriform carcinoma. At follow‐up, 10 to 21 years after diagnosis, none of the 35 patients with classical invasive cribriform carcinoma had died as a result of this initial carcinoma and 30 remained alive. Of the 16 remaining patients, whose tumours showed areas of less well differentiated carcinoma, only six remained alive. However, the adjusted 10 year survival rate of these patients in this mixed group was significantly better than that of invasive carcinoma in Edinburgh. Invasive cribriform carcinoma in its classical form, is a histological subgroup of invasive carcinoma with the same excellent prognosis as that of invasive tubular

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1983.tb02265.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

Germ cell tumours may imitate various structures of the developing embryo and foetus. Certain structures have, however, very rarely or never been observed in these tumours. Thus the presence of hepatic tissue in testicular germ cell tumours has not been reported. In a series of 37 non‐seminomatous testicular tumours seven tumours contained epithelial structures showing morphological and functional resemblance to liver cell trabeculae. These structures were present in tumours with yolk sac tumour (YST) components and most of the tumours also contained teratoid elements. With the immunoperoxidase technique the epithelial structures were heavily stained for alpha‐foetoprotein (AFP) and ferritin in all cases, while positive staining for albumin, prealbumin and transferrin was occasionally found. Alpha‐i‐antitrypsin and haemoglobin F were demonstrated in few scattered cells. Whether or not these epithelial structures should be included among the various patterns of YST or considered to be teratoid components is uncertain. It is suggested that examinations of the heterogeneity of the concomitant serologic AFP may support one or other ass

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1983.tb02266.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

The Kiel and Lukes‐Collins classifications of non‐Hodgkin's lymphomas are the only classifications based on immunological concepts. Their cytological types have been confirmed by numerous immunological studies as B‐ and T‐cell types and have been related to clinicc‐pathological entities. In this presentation, the cytological types of the two classifications are compared. Eleven of the 13 major types of the Lukes‐Collins classification are essentially identical with the Kiel counterparts, though the terminology differs in four of the 11 types. In the two types in which discordance occurs, the relationship between the types of the two classifications are clarified. As a result, the two classifications are placed into effective alignment for understanding and translating terminological differences. Both classifications represent sound bases for morphological diagnoses and also for relating the results of the broad range of current and future immunological studies to

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1983.tb02267.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

The benign ‘Triton’ tumour is a neural tumour with benign rhabdomyomatous differentiation: it must be distinguished from the better known malignant counterpart. We describe the first case outside the peripheral soft tissues and the first to be studied ultrastructurally. It also represents the second lesion identified in an adult pati

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1983.tb02268.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

A case of epithelioid sarcoma of scalp has been studied by light and electron microscopy, histochemistry and immunocytochemistry. The results suggest that epithelioid sarcoma is a tumour of myofibroblasts. The epithelioid appearance results from gross and disordered accumulation of cytoplasmic intermediate filaments (10 nm diameter), possibly of desmin type, producing the misleading light microscopical resemblance to epithelioid histiocytes and biphasic pattern of synovial sarcoma. The cause of the filament accumulation is unknown but it may represent a degenerative change leading to necrosis, a characteristic feature of epithelioid sarcoma.

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1983.tb02269.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY