摘要:

A wide variety of disease processes, each requiring different therapy, may give rise to granulomatous and vasculitic pulmonary lesions, making accurate aetiological diagnosis essential. For this, adequate sampling of tissue is necessary, and this usually requires open lung biopsy in order to obtain sufficient material for microbiological, immunocytochemical and ultrastructural as well as histopathological investigation. Many cases diagnosed as lymphonatoid granulomatosis are examples of extranodal lymphoma. It is suggested that this is an inappropriate name and that such cases should be referred to as pulmonary lymphomas and the phenotype specified.

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1991.tb00043.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

Tylosis is an autosomal dominant inherited defect of keratinization, associated in two Liverpool families with a high risk of eveloping oesophageal squamous carcinoma. In 29 individuals, followed by regular endoscopy and biopsy, we have noted several morphological abnormalities of the epithelium in this pre‐cancerous condition. A control group of 43 non‐tylotic patients with normal oesophageal histology and a further 26 patients with acute oesophagitis was used for comparison. Recognizable dysplasia was confined to the older age range in the tylotic group and was present in four patients. Almost half of the patients showed acute inflammation. Abnormalities of maturation were common, the most frequent being the presence of prominent basophilic inclusions and clear cell acanthosis, with parakeratosis and frank surface keratinization present in smaller numbers. There was, however, no statistically significant difference between the tylotic and inflamed control groups for any of these features. The only feature to show a significant difference between these groups was the presence of individual cell keratinization. The results suggest that in the oesophageal epithelium of the patients with tylosis, inflammation is the predominant abnormality, together with individual cell keratinization, and that these lesions appear in a much younger age group than dyspla

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1991.tb00044.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

The phenotype of 165 gastrointestinal stromal tumours was studied by immunohistochemistry. In each case the phenotype was compared to the histological diagnosis. The phenotype was muscle in 49 tumours (30%), neural in 18 (11%), histiocytic in 20 (12%) and mixed in five (3%); 68 tumours (41%) were positive for vimentin only, four tumours had no markers and one tumour was positive for keratin only. Histologically, the tumours were classified as smooth muscle, probably smooth muscle, probably nerve sheath tumours or tumours of undetermined differentiation, In 30 istologically unequivocal muscle tumours, the phenotype was muscle in 28. Half of them, all benign, arose in the oesophagus or gastric cardia. Apart from this group, there was no correlation between phenotype, site of tumour and histological differentiation. Actin was a more sensitive muscle marker than desmin. With the exception of oesophageal tumours, the histological appearances alone could not establish a diagnosis of malignancy and were inadequate in evaluating differentiation. Immunohistochemical examination determined differentiation in 54% of the tumours, but this finding should be interpreted with caution in terms of histogenesis. It allowed us. however, to specify the differential diagnosis in 57 tumours in which the histological diagnosis was uncertain.

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1991.tb00045.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

Tissue from 15 livers with primary sclerosing cholangitis, obtained at transplantation, was examined histologically with respect to: small and medium sized bile duct lesions; large bile duct lesions; fibrosis/cirrhosis; and parenchymal changes. Lesions affecting small and medium‐sized bile ducts were quantified by determining the percentage of 20 portal tracts involved. The two characteristic bile duct lesions of primary sclerosing cholangitis, periductal fibrosis and fibro‐obliterative scars, were largely confined to medium‐sized portal areas. Although present in each case, the number of such lesions varied considerably. Loss of bile ducts was the most conspicuous feature in small portal tracts, where the diagnostic duct lesions of primary sclerosing cholangitis were rarely observed. Inflammation, ulceration and cholangiectases of large intrahepatic ducts were common, and appear to be useful additional diagnostic fea

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1991.tb00046.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

Subacute cutaneous lupus erythematosus is an uncommon, non‐scarring variant oflupus erythematosus which has received scant attention in the pathology literature. Its recognition as a distinct entity is important, as, although mild systemic features may be associated, there is characteristically a relative absence of life‐threatening renal or central nervous systemic involvement. Subacute cutaneous lupus erythematosus may be clinically sub‐divided into the more common annular and the rarer papulosquamous (psoriasiform) variants.A clinicopathological study of five cases of the annular variant is presented with a review of the literature. We highlight the histological and ultrastructural appearances. Discriminatory features from the other variants of lupus erythematosus and additional conditions with which it may be confused, including lichen planus and acute graft‐versusmost disease, are di

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1991.tb00047.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

Cell proliferation indices and DNA content have been determined in 18 intradermal naevi, 40 dysplastic naevi and 16 superficial malignant melanomas (<0.76 mm depth of invasion) using flow cytometry. In this study, proliferation indices of intradermal naevi and dysplastic naevi were not significantly different from eachother. Abnormalities of DNA ploidy were not identified in the intradermal naevi or dysplastic naevi; whereas three of the malignant melanomas were aneuploid. In addition, cellular proliferation was increased within the group of malignant melanomas, in comparison with the naevi.This study has found no evidence to indicate that sporadic dysplastic naevi were more likely than intradermal naevi to transform to malignant melanoma, when objective criteria were employed. However, dysplastic naevi could be distinguished from some early malignant melanomas by absence of aneuploidy and by low cell proliferation indices.

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1991.tb00048.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

Lichenoid dermatosis is a pattern description of a variety of cutaneous lesions which primarily affect the dermoepidermal junction. Involvement of skin appendages has been restricted to hair follicles in lichen planopilaris and discoid lupus erythematosus. Sweat gland involvement has not been described in the four common members of this group, namely, lichen planus, discoid lupus erythematosus, fixed drug eruptions and erythema multiforme, although structural abnormalities have been reported in graft‐versus‐host disease. In a detailed morphological study of 59 cases, including lichen planus (12), discoid lupus erythematosus (18), fixed drug eruption (14) and erythema multiforme (15 78% (47/59) showed sweat, gland abnormalities. The abnormalities included vacuolation of cell cytoplasm, with and without lymphocytic infiltration, apoptosis of basal cells and basal cell hyperplasia of the excretory ducts which predominantly affected the portion of the duct adjoining the acrosyringium. The portion of the duct close to the secretory gland was only involved in continuity and the secretory glands were unaffected. These abnormalities of the sweat gland mostly constitute primary involvement by the disease process in contrast to structural abnormalities secondary to fibro

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1991.tb00049.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

Adhesion molecules are considered to have an important role in inflammatory reactions. We investigated the kinetics of ICAM‐1 expression on keratinocytes and correlated this with the numbers of lymphocytes expressing LFA‐1 in the dermis and epidermis of evolving allergic contact dermatitis reactions. In nickel‐sensitive individuals, after application of a nickel patch, increased expression of ICAM‐1 on keratinocytes was observed as early as 3 h and reached a maximum at 48 h. The number of lymphocytes expressing LFA‐1 in the dermis and epidermis was greatest at 48 h. The LFA cells were observed to be in close proximity to keratinocytes expressing ICAM‐1, thus supporting the hypothesis that T‐lymphocytes attach to keratinocytes via LFA‐1/I

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1991.tb00050.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1991.tb00051.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

We have studied 27 oligodendrogliomas with a panel of antibodies (vimentin, GFAP, S‐100 protein, myelin basic protein, CAM 5.2) and of lectins (WGA, Con A, PNA, RCA, DBA, SBA) to different glycoproteins. There were 16 well‐differentiated tumours, including one gliofibrillary and 11 anaplastic oligodendrogliomas, three of which were gliofibrillary. Four cases showed positivity for vimentin, three of which were anaplastic tumours. Fifteen cases were positive for S‐100 protein (nine well‐differentiated and six anaplastic tumours) and 13 contained GFAP‐positive cells (three well‐differentiated and 10 anaplastic tumours). WGA binding was positive in 75% of well‐differentiated and 63% of anaplastic oligodendrogliomas, the corresponding figures were 50% and 45% for PNA, 37% and 81% for Con‐A and 25% and 54% for RCA. On the basis of the results with lectin binding, we believe that there are changes in the spectrum of tumour cell‐associated lectin‐like proteins during malignant transformation. Our observations also suggest at the pattern of lectin expression can undergo substantial changes in the course

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1991.tb00052.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY