摘要:

This article reviews the clinicopathological features of several recently described soft tissue tumours, namely ossifying fibromyxoid tumour, angiomyofibroblastoma, epithelioid angiosarcoma, retiform haemangioendothelioma, intra‐abdominal desmoplastic small cell tumour, spindle cell liposarcoma and low grade fibromyxoid sarcoma. Conceptual changes are also discussed. These include the relationship between Ewing's sarcoma and peripheral primitive neuroectodermal tumour, the proposed use of the term atypical lipoma for a subset of well differentiated liposarcomas, and the occurrence at a wide variety of sites of inflammatory myofibroblastic lesions of uncertain biological potential. In addition, advances in the study of soft tissue lesions at the molecular and cytogenetic levels are outlined, with particular emphasis on the recent identification of tumour‐specific karyotypic abnormalities in a wide variety of sarco

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1995.tb00019.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

The so‐called sclerosing haemangioma of the lung is an uncommon tumour with predilection for Chinese women. Twenty‐five cases showed a predominantly solid/cellular pattern in three, a haemorrhagic/angiomatoid pattern in three, a papillary pattern in one, a sclerotic pattern in one, and in seventeen, a mixed pattern was observed. Immunostaining revealed the expression of epithelial membrane antigen, vimentin (V9), and CD68 (KP1) in all tumours, cytokeratin in 23 (Cam 5.2 and MNF116), S‐100 protein in 22 and alpha‐smooth muscle actin in 23 tumours. All tumours were negative for surfactant, factor VIII‐related antigen, CD34 and MAC387. There was strong labelling for progesterone receptor protein in 20 tumours, and oestrogen receptor protein was weakly stainable in 13 tumours. The histogenesis of sclerosing haemangioma of the lung is controversial and origin from pneumocyte, histiocyte, mesothelial, endothelial and Clara cell has been suggested. Our immunohistochemical findings, in the largest series studied to date, indicated a cytokeratin+, vimentin+, epithelial membrane antigen+, alpha‐smooth muscle actin+, CD68+, oestrogen+, progesterone+, phenotype, confirming an epithelial lineage but which does not clearly correspond to any recognized cell in the respiratory system. The distinct expression of progesterone and oestrogen receptor proteins correlates with the predilection of this tumou

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1995.tb00020.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

We have studied 14 cases of low‐grade, splenic marginal zone, B‐cell non‐Hodgkin's lymphoma. The clinical presentation in all cases was with splenomegaly and, in 10 cases, circulating neoplastic lymphoid cells in the peripheral blood with involvement of bone marrow. In all cases the splenic white pulp was hyperplastic with expansion of marginal zones and varying degrees of infiltration of germinal centres by neoplastic cells. The cells were a mixture of medium sized lymphocytes with moderate amounts of cytoplasm and finely dispersed nuclear chromatin, together with occasional blast cells with small nucleoli. Satellite red pulp aggregates of tumour cells centred on small epithelioid cell clusters were seen in all cases. These appear to be a characteristic and diagnostically important feature of splenic marginal zone lymphoma. The tumour cells expressed CD20, CD45RA, bcl‐2 and the antigens detected by MB2. All cases expressed IgM with light chain restriction. In addition, IgD was expressed in four cases. The follicular dendritic cell network was disrupted in those follicles which were infiltrated by tumour cells. A network of stromal myoid cells, at the periphery of the marginal zone, identified by expression of α‐smooth muscle actin, was preserved. Alpha‐smooth muscle actin positive dendritic cells were also seen within and around satellite tumour nodules in

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1995.tb00021.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

Thirteen cases of nasal lymphomas with T‐cell or natural killer (NK)‐cell phenotype were studied, with attention to clinical presentation and follow‐up, the presence of Epstein‐Barr virus (EBV) using in situ hybridization (EBER), the immunophenotype, and the presence of cytotoxic granules. All but two patients presented with stage I disease. In three cases local progression resulted in involvement of the central nervous system. When dissemination occurred, this was predominantly to extranodal localizations, in two cases to the skin. Response to therapy was highly variable, but patients treated with radiotherapy with or without additional chemotherapy had a better prognosis than patients treated with initial chemotherapy alone. All lymphomas were associated with EBV, and most cases howed cytotoxic features, ten of which were CD56 positive. In eight cases a T‐cell origin was proven, but in five ases a possible NK‐cell origin could not be excluded, No clinical differences were seen between true T‐cell lymphomas and possible NK‐cell neoplasms. Nasal T‐cell lymphomas should be considered as a distinct clinicopathological entity, strongly associated with EBV, and with cytotoxic features in most cases. No prognostic parameters were detected to predict dissemination and re

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1995.tb00022.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

Aseptic loosening of prosthetic components is the most important long‐term complication of total joint replacement. To investigate the underlying destructive mechanisms, periprosthetic tissues from both well‐fixed and loosened sites from six patients, undergoing surgery for aseptic loosening of knee or hip prostheses, were analysed in detail by immunohistochemical methods for the presence, of matrix metalloproteinases and tissue inhibitor of metalloproteinases‐1 (TIMP‐1). The tissues contained small numbers of cells positive for either collagenase, stromelysin, gelatinase A or TIMP‐1; these were randomly distributed, neither specifically next to the bone interface nor to wear particles, and the number of positive cells did not correlate with macroscopic observations at operation. Gelatinase A was co‐localized in cells with prolyl‐4‐hydroxylase, an enzyme involved in collagen synthesis. The predominant cell type in these tissues was shown to be the macrophage by the use of cell marker antibodies. Dual localization was not technically possible but the results strongly suggest that monocyte/macrophages were the primary source of gelatinase A and TIMP‐1. Stromelysin was immunolocalized on connective tissue matrix in four patients, and gelatinase A in one patient, and were also observed in tissues in which there was no evidence of cellular synthesis of these enzymes. This suggests that secretion had taken place previously, resulting in enzyme bound to matrix for some time. Taken together, these data indicate that localized focal connective tissue remodelling occurs in periprosthetic tissues from both well fixed a

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1995.tb00023.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

Eighty‐two selected gastric mucosal biopsy or resection specimens were stained both conventionally, to classify subtypes of intestinal metaplasia and carcinoma, and immunohistochemically with a mouse monoclonal antibody (MMM‐17), raised against normal human colonic mucin, which has an affinity for di‐ and/or tri‐O‐acetylated sialomucin. The aims of the study were to reassess the prevalence of O‐acetylated sialomucins in normal, metaplastic and carcinomatous gastric mucosa and to investigate whether the production of these mucins by intestinal metaplasia is related to its associated mucosal pathology. O‐acetylated sialomucins were not seen in normal mucosa. They were, however, prevalent in all sub‐types of metaplastic (64.8%) and carcinomatous (42.9%) mucosa. Type 1 intestinal metaplasia was significantly more likely to contain this type of mucin ifHelicobacter pyloriinfection was identifiable in the adjacent gastric mucosa (81.0% v. 38.5%,P<0.025). Type 3 showed a similar, albeit nonsignificant, relationship (100% v. 62.5%). O‐acetylated sialomucins are, therefore, much more prevalent in gastric intestinal metaplasia and carcinoma than previously recognized by conventional staining techniques. The production of this type of mucin by intestinal metaplasia may reflect an adaptive response to alterations in the luminal environment such as an increase in

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1995.tb00024.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

Although approximately 50% of patients with non‐invasive (Ta) papillary transitional cell carcinoma show no recurrence of their disease, current histopathological approaches cannot distinguish this sub‐group from those patients in whom the disease will recur. In this 5 year retrospective study, we have shown that cytokeratin 20 (CK20) was expressed in 19 of 29 (65.5%) of non‐invasive papillary tumours of grades 1 or 2. CK20 expression patterns were predictive of disease non‐recurrence in a sub‐group of eight patients, representing 51.7% of patients with non‐recurrent disease. In normal bladder mucosa, CK20 expression was restricted to the terminally‐differentiated superficial cell. In eight CK20‐positive tumours which showed no recurrence at 5 years, CK20 expression was either restricted to, or most intense in, the luminal cells of the papillae. This pattern of expression was not seen in any of the 15 tumours from the recurrent group. Disruption of normal CK20 expression was highly significantly correlated with recurrent tumours. These results suggest that changes in the expression of differentiation‐associated antigens, such as CK20, may be useful in predicting benign versus malignant behaviour and may, therefore, be useful in defining tre

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1995.tb00025.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

The clinical and pathological features of four cases of the rare entity diffuse leiomyomatosis of the uterus are described. The patients, who ranged in age from 28 to 35 years, presented with a six month to ten year history of abnormal uterine bleeding, dysmenorrhoea and an enlarged uterus. Hysterectomy in each case revealed a symmetrically enlarged uterus containing numerous small ill‐defined leiomyomatous nodules. On microscopic examination the nodules were composed of compact fascicles and interweaving bundles of plump uniform benign smooth muscle cells. The nodules blended with each other and merged imperceptibly with the surrounding less cellular normal myometrium. The four patients are alive and well without further treatment. The follow‐up period ranged from six months to twelve ye

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1995.tb00026.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

We previously observed, in decalcificated bone specimens, intraosseous crystal deposits with morphological and analytical similarity to calcium pyrophosphate dihydrate. We have now been able, by a combination of more detailed morphological studies of these and similar cases, and by infrared spectroscopy in three cases, to show that this is, in fact deposition of the secondary calcium salts brushite and monetite, occurring as an artefact during formic acid decalcification. Our earlier postulate of bone as an additional primary crystallization site for calcium pyrophosphate dihydrate is effectively disproved. This artefact deserves wider recognition.

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1995.tb00027.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1995.tb00028.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY