摘要:

A new method (KOH/AB 1.0/PAPS) for the simultaneous detection of sulphated and non‐sulphated sialomucins in intestinal epithelium was compared to the standard high iron diamine/alcian blue(HID/AB) technique. Although there was no difference in the sensitivity of the methods in detecting cells containing only one type of mucin, detection of cells containing both types was twice as effective with the KOH/AB 1.0/PAPS method. This indicates that previous investigations using only HID/AB may have seriously underestimated mucosal non‐sulphated mucin content and raises doubts about the validity of some of the conclusions reached concerning the pre‐neoplastic potential of ‘transitional’ mucosa of

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02794.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

The present study concerns eight patients with ulcerative colitis treated by total colectomy and ileorectal anastomosis and subjected to follow‐up rectal biopsies who later developed precancer (two cases) or carcinoma in the retained rectum. We report the results of the biopsies and the detailed mapping of lesions in the resected rectal stump to highlight certain features which may lead to increased detection rate of early malignancy. Two groups of patients emerged. Group A: (i) in all four cases the follow‐up biopsies showed increasing severity of dysplasia; (ii) altered mucin secretion with predominance of sialomucins was seen in the biopsies even in the absence of inflammation or dysplasia; (iii) the biopsy findings (morphological and secretory) mirrored those observed in the rectal stump; (iv) in three, the lesions were villous polypoid growths, of which two were invasive carcinomas. Group B: (i) in none of the cases was dysplasia seen in the biopsies and mucus secretion was normal; (ii) similar features were seen in the rectal stump; (iii) all had invasive carcinoma of which three were flat ulcerated lesions. The different behaviour of carcinoma in the two groups almost certainly reflects the different tumour phenotype characteristics and this is a matter for further study. From the practical point of view we emphasize the risk of relying on biopsy evidence of dysplasia alone as an indicator of malignancy and the need for additional immunological or histochemical tests to assess the individual risk of cancer in coli

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02795.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

Seven patients with perianal and anorectal giant condyloma acuminatum (Buschke‐Loewenstein tumour) are presented. In five of these patients histopathological examination of the lesions disclosed varying degrees of dysplasia and/or squamous carcinoma. The clinicopathological features and aetiology of perianal and anorectal condylomata acuminata, giant condyloma acuminatum and verrucous carcinoma are discussed. The viral induction and malignant transformation of these papillomatous squamous lesions are emphasize

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02796.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

The characteristic adrenal lesions of five patients with bilateral primary adrenocortical nodular dysplasia and Cushing's syndrome developing in adolescence are presented histopathologically, and in two cases ultrastructurally. Two of the patients were siblings with additional extra‐adrenal lesions such as pigmented spots on the face, myxoid cutaneous tumours and in one case familial cardiac myxoma. The adrenals were small with an uneven surface due to numerous small brown to black pigmented nodules in the inner cortex. The nodules were composed of eosinophilic giant cells filled with lipofuscin granules. The familial cases in addition revealed a pronounced disorganization of the adrenocortical architecture with capsular disruption and infiltration of periadrenal fatty tissue. The early onset of Cushing's syndrome in the second decade, the bilateral involvement of adrenal glands despite ACTH independence and the familial occurrence in combination with other peculiar rare lesions are strongly suggestive of a malformative process of the zona reticularis of the adrenal gland

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02797.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02798.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

Cholesterol granulomas are infrequent and rarely described renal lesions occurring usually in the interstitium, characterized by clusters of foreign body giant cells containing ingested cholesterol crystals. Over a seven‐year period, we observed them in 5 of 789 (0.6%) renal biopsies from patients with nephrotic syndrome of varying glomerulopathies. Four patients had renal insufficiency at the time of biopsy, while the fifth developed it within three months. To define the lesions we studied the morphogenesis of cholesterol granulomas by light and electron microscopy. Initially small cholesterol crystals formed in tubular epithelium; the crystals enlarged and were released into tubular lumina where they elongated or were passed in the urine. Further luminal growth caused the crystals to become lodged at some point in the nephron, distort and destroy tubule cells, and pierce through basement membranes with subsequent exposure to interstitial monocytes and formation of granulomas. It is likely these morphological abnormalities evolve from lipid disturbances in the nephrotic syndrom

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02799.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

We report a unique angiosarcoma of the skin of the face in which a large part of the tumour was of granular cell appearance. Histologically the granular cells resembled those of conventional granular cell tumours. By electron microscopy the granules were identical to those of granular cell tumours but other features were lacking. Stains for vimentin and factor VIII related antigen were positive, but for S‐100 protein and CEA were negative. The occurrence of granular cell change in an angiosarcoma supports the view that granular cell tumours are histogenetically divers

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02800.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

Three patients with an unusual stenosing lesion affecting the upper respiratory tract are described. The lesion involved the mucosa of the nasal septum and lateral nasal wall in two cases and the mucosa of the sub‐glottic region of the larynx in one. The lesion leads to thickening of the sub‐mucosal connective tissues by an usual pathological process. It begins as a focal peri‐vascular sub‐epithelial exudate of eosinophils accompanied by collections of plasma cells and lymphocytes without fibrinoid necrosis. These foci progress to form extensive areas of peri‐vascular fibrosis showing a characteristic angiocentric whorling with an ‘onion‐skin’ pattern. This process leads to thickening and matting of the mucosa which becomes adherent to the underlying structures. As fibrosis progresses, the lympho‐plasmacytic component regresses but the eosinophils remain. The fibrosis does not resolve and the consequent stenosis requires surgical relief. No other site appears to be affected by this process, but one case was associated with granuloma faciale. The cause is unknown. We have given the term ‘eosinophilic angiocentric fibrosis of the upper respiratory tract’ to this condition to encompass

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02801.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

A 27‐year‐old patient contracted a Coxsackie virus A9 meningitis at 33 weeks gestational age. Two weeks later a macerated female stillborn infant was delivered. The placenta showed a diffuse perivillous fibrin deposition with villous necrosis and inflammatory cell infiltration and yielded Coxsackie virus A9 on culture. Post‐mortem examination of the fetus showed only minimal inflammatory changes in the cardiac connective tissue and the subarachnoid

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02802.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02803.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY