摘要:

Endocrine cells are normal inhabitants of the para‐urethral, Bartholin's and endocervical glands and of mesonephric rests. All these cells were characterized as serotonin‐storing cells. In the para‐urethral and Bartholin's glands, serotonin‐containing cells were most often found in the transitional epithelium of excretory ducts. Endocrine cells participated in some pathological conditions. Abundant argentaffin cells were observed among the terminal ductules in chronic bartholinitis and serotonin‐storing cells were identified in a peculiar ectocervical epithelium. Numerous serotonin‐storing cells were detected in a well‐differentiated adenocarcinoma of cervix occurring in a patient with the Peutz‐Jeghers syndrome. Argyrophilic cells were present in cases of endometrial carcinomas; a striking feature was the demonstration of gut peptide hormones in an unusual type of endometrial adenocarcinoma. Finally, serotonin‐storing cells were a constituent of Brenner tumours. It is suggested that a similar endocrine pattern may be shared by tissues originating from both Müllerian ducts and th

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02430.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

PGP.9.5 is a soluble protein isolated from brain and is a general marker for neuronal and neuroendocrine tissue. Its function is not known. Until now neurone specific enolase (NSE) has been the only general marker for the paracrine system and tumours derived from it. Seventy‐four neuroendocrine tumours, 17 melanocytic naevi, 51 melanomas and four granular tumours were stained immunohistochemically for PGP 9.5 and NSE. A variety of pulmonary and non‐neuroendocrine tumours were also stained. Two so‐called goblet cell carcinoids of the appendix were included in the series. Using NSE 59/74 neuroendocrine tumours were positive and 58/74 stained for PGP 9.5. In combination 63/74 of these tumours were positive for either NSE or PGP 9.5 or both. Staining for PGP 9.5 was better for demonstration of nerves in routinely processed material than was staining for NSE. Twenty‐one out of 43 primary melanomas stained for PGP 9.5 and 36 showed staining for NSE. Only two of eight metastatic melanomas stained for PGP 9.5 while seven of these eight stained for NSE. Six of 17 melanocytic naevi stained for PGP 9.5 and five stained for NSE. All four granular cell tumours stained for PGP 9.5 and NSE. Both ‘goblet cell carcinoids’ of the appendix were negative for NSE and PGP 9.5. Fifteen out of 32 pulmonary cancers showed staining for either marker and no non endocrine tumour showed any specific staining. Staining for PGP 9.5 is a valuable additional probe in the exploration of the paracrine system and the diagnosis of tumours aris

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02431.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

A series of 13 myxoid leiomyosarcomas (LS) is presented. Seven were from genital and six from extragenital sites and most tumours were large. The myxoid matrix in some tumours separated individual tumour cells; occasionally the myxoid areas were trabecular in shape, resulting in a plexiform tumour pattern; in other tumours there were many closely spaced small mucoid pools which produced a pseudoglandular pattern; in one tumour the pools were large and confluent, and macroscopically evident as gelatinous areas. Four patients who were followed up and whose tumours had shown an absent or very low mitotic rate, nevertheless developed recurrences or metastases; hence a low mitotic count was an unreliable prognostic criterion. The myxoid LS studied did not differ in clinical behaviour and prognosis from the more common solid counterparts. Myxoid LS should be included in the differential diagnosis of any myxoid malignant soft tissue tumour.

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02432.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

Ultrastructurat features of 12 liver biopsies from patients with chronic active hepatitis were studied, particular attention being paid to endothelial cells. In areas of piecemeal necrosis and parenchymal inflammation sinusoidal endothelial cells show swelling of the cytoplasm, protrusion of the cell body into the sinusoidal lumen, increase in micropinocytotic vesicles and appearance of numerous dense bodies. This cell type is termed ‘active endothelial cell. Subsequent changes include enlargement of the Golgi complex, increase of rough endoplasmic reticulum in cytoplasmic processes with concomitant decrease of dense bodies, appearance of a fuzzy coat and formation of hemidesmosomes in close relationship to basement membrane‐like material and reticulin fibres in the space of Disse. The latter ultrastructural characteristics correspond to those of ‘fibroblastic reticulum cells’ described in lymph nodes. Active endothelial cells and fibroblastic reticulum cells may play a protective role in liver parenchymal inflammation by reducing the accessibility of noxious agents from the blood stream to liver parenchymal cells, and be crucial in the initiation of perisinusoidal f

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02433.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

Three cases of invasive mammary carcinoma with stromal osteoclast‐like giant cells are reported. All the specimens were grossly of reddish‐brown colour. On microscopical examination two were invasive ductal carcinomas and the third was of mixed ductal. and mucoid type. In the stroma all specimens showed numerous osteoclast‐like giant cells, vascular proliferation, and accumulation of haemosiderin pigment. Supplementary immunohistochemical and electron microscopical investigations indicated that the giant cells originated from mononuclear stromal cells with only slight histiocytic properties. The giant cell formation was probably induced by the infiltrating carcinomatous tissue which is also believed to induce new blood vessel formation. However, there is no evidence of a direct relationship between these fea

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02434.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

Mucoepidermoid carcinoma of the thyroid (MECT) has been recently recognized as a pathological entity. The origin of MECT is unknown but the morphology of this tumour closely resembles features seen in the ultimobranchial body (UB) vestiges. Recent studies in man have shown strong evidence that the so‐called solid cell nests (SCN) of the thyroid may correspond to the human UB vestiges. To investigate whether these vestiges are the site of origin of this tumour a comparative study on SCN and MECT was undertaken. One hundred autopsied thyroids cut at 2–3 mm intervals were studied for the presence of SCN. Histochemical (H&E, Alcian blue‐PAS, Mayer mucicarmine) and immunohistochemical studies (calcitonin, epidermal keratin) were perfonned in SCN and four cases of MECT. Sixty percent of thyroids were found to have SCN. They were mainly composed of epidermoid‐like cells arranged in solid structures or lining cystic cavities, tubular and follicular structures. Solid clusters usually showed lumina containing PAS‐positive and mucin‐positive cell debris. Mucin stains also revealed mucinous cells placed around lumina filled by mucosubstances. Characteristic PAS‐positive rounded bodies were found filling lumina as well as within some apical epidermoid‐like cells, mucinous cells and cell debris. An obvious transition between these cells, cell debris and mucosubstances filling the lumina was noticed; suggesting degenerative changes undergone by the epidertnoid‐like cell. MECT basically presented all histological and histochemical features shown by SCN, furthermore, calcitonin containing cells were observed in 54% of SCN, while a metastatic MECT also showed scattered C cells within solid islands. The presence of epidermal keratin in all SCN and MECT, together with the previous findings, are strong evidence that MECT could originate in the SCN or

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02435.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

Liver cell dysplasia (LCD) was found in 28 (60%) of 47 patients with hepatocellular carcinoma (HCC); 22 (79%) of them had associated liver cirrhosis. LCD was more frequently observed in posthepatitic cirrhosis (82%) than in the other forms. Carcino‐embryonic antigen (CEA), alpha‐ 1‐antitrypsin (AAT) and alpha‐fetoprotein (AFP), as demonstrated by the peroxidase‐antiperoxidase method, were similarly expressed both in normal and in dysplastic cells. Hepatitis B surface antigen was found in eight cases (17%), six of which were associated with LCD. HBsAg was rarely found in dysplastic cells and frequently displayed a peculiar perinuclear pattern. The possible preneoplastic role of LCD is

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02436.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

The clinical notes and histology of 374 patients treated by colectomy and ileo‐rectal anastomosis for ulcerative colitis were reviewed. Only those with definite diagnosis of ulcerative colitis and follow‐up rectal biopsies were included (171 cases). Morphology and patterns of mucin secretion were investigated to assess whether abnormal mucin with predominance of sialomucins is a useful indicator of malignancy‐risk. Carcinoma has developed in six patients and ‘precancer’ in seven. The results show coexistence of dysplasia and sialomudn even in the absence of inflammation in all but three biopsies; in contrast the presence of both dysplasia and normal mucin profile was found in less than 1%. A significant correlation was noted between an inflamed mucosa and the development of cancer or precancer, the presence of sialomucins and the appearance of dysplasia. Sialomucins showed a greater sensitivity in detecting cancer than dysplasia (75% versus 30%). However, dysplasia was notably more specific (94% compared with 50%), hence its greater predictive value as indicator of malignancy (50% as against 15% for a positive sialomucin result). Mucin stains on routine fixed paraffin‐embedded tissue provide a simple screening method to sharpen the assessment of dysplasia and cancer‐risk in patients with ulcerative colitis despite the limitations referred to above. The lack of definite evidence of dysplasia in four patients who developed malignancy without premalignant changes in the rectal biopsies emphasises the need for frequent multiple biopsies in patients with an ileo‐rectal anastomosis for ulc

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02437.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

A patient who abstained from alcohol consumption but who had asymptomatic chronic progressive hepatomegaly, mild disturbance of liver function tests and hepatitis resembling alcoholic hepatitis (nonalcoholic steatohepatitis) developed glucose intolerance several years after the hepatitis was diagnosed. The patient had a family history of both diabetes and chronic liver disease. A lesion resembling alcoholic hepatitis in a patient who denies alcohol consumption, may be diabetic or pre‐diabetic in aetiology and such a patient should be followed up with glucose tolerance test

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02438.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

A case of verruciform xanthoma is described, representing the fourth case of an extraoral lesion and the first case of xanthoma of this type to involve the true skin. The differential diagnosis from other types of xanthoma, and from granular cell tumour, verrucous carcinoma and other lesions is discussed. This lesion is well known to oral pathologists but deserves wider recognition by histopathologists in general.

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02439.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY