摘要:

In a series of 316 surgically removed spleens, a histological and supportive immunohistological study was performed on methylmethacrylate sections. The structure of the human white and red pulp differs from the rat spleen in many respects, e.g. the human lacks the marginal sinus and the architecture of the periarteriolar lymph sheath seen in the rat. In man, the lymphoid compartment is in both white and red pulps. In the white pulp separate periarteriolar T‐cell areas contain a large lymph‐vessel plexus, which was reconstructed in serial sections. The circulation in the red pulp is discussed. The area between the red and white pulp, the perifollicular zone, is not the equivalent of the marginal sinus in the rat. Its anatomy in man suggests that it is an area formed from red pulp during the expansion of new follicles. The micro‐anatomy was analysed in 119 controls. In cases of traumatic rupture the white pulp showed evidence of stimulation. A pathognomonic histological picture was not found in idiopathic thrombocytopenic purpura. In haemolytic anaemia the pulp cords were engorged by erythrocytes accompanied by a decreased B/T cell ratio in autoimmune haemolytic anaemia and by an increased B/T cell ratio in congenital spherocy

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02841.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

This paper describes the light and electron microscopy and monoclonal antibody findings in the lymph nodes of nine patients with mycosis fungoides. Four cases showed dermatopathic change characterized by close association between small convoluted T4 lymphocytes and T6 antigen‐presenting cells (Langerhans' and indeterminate dendritic cells) in the sinuses and paracortical zones. The T4:T8 ratio was between 3 and 5:1. One case showed dermatopathic change but included large convoluted T4 lymphocytes and occasional T10 lymphocytes. The T4:T8 ratio was 4:1. The antigen‐presenting cells were mostly T6 negative (interdigitating reticulum cells). One case showed extensive paracortical expansion by small and large convoluted T4 lymphocytes. The T4:T8 ratio was 20:1. Few B lymphocytes and antigen‐presenting cells were present. Two cases showed partial and one case total effacement by atypical lymphoid tissue. This included small and large convoluted T4 lymphocytes and T4 immunoblasts. The T4:T8 ratios were between 30 and 40:1. The changes in their antigen‐presenting cell population were complex. Langerhans' cells in one case generally failed to express T6 antigen and in two displayed histiocyte features. In one case, both immature and budding type C retrovirus‐like particles were identified in Langerhans cells. One extracellular mature type C virus‐like particle was identified in another case. No ultrastructural distinction could be made between similarly sized primary lysosomes and possible intracytoplasmic mature type C retrovirus particles. These findings support the hypothesis that mycosis fungoides may represent an altered dermatonodal cycle resulting from an interaction between retrovirus, Langerhans' cells and

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02842.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

Ultrastructural examination of five adenoid cystic carcinomas, three breast and two salivary gland, reveals identical patterns of tumour cell differentiation, organization and distribution of cellular products (Zaloudek, Oertel&Orenstein 1984). In both sites, there is proliferation of two populations of cells, one with characteristics and organization of duct‐type luminal epithelial cells and a second that forms the principal proliferating component and has the overall organization and appearance that would suggest that they represent modified myoepiphelial cells. Recent ultrastructural studies also indicate that tumour cell types and histological organization similar to those described for adenoid cystic carcinoma occur during histodifferentiation of salivary gland pleomorphic adenoma (Dardicket al. 1983a, b). The characteristic histological pattern of adenoid cystic carcinoma is dependent on the formation of pseudolumina containing proteoglycans and reduplicated basal lamina. Similar, but smaller, lumina of like organization and contents are evident in some cases of pleomorphic adenoma. Both the ultrastuctural similarities of the tumour cell types and their organization, in adenoid cystic carcinoma and pleomorphic adenoma, suggest that these tumours have a similar histogenetic basis. The fact that one lesion is malignant and the other benign does not preclude common types of tumour cells and developmental processe

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02843.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

Between 1975 and 1983, 9434 colonoscopic examinations were performed at the University Hospital of Zürich. Localized vascular ectasia was detected in 84 patients and there were 48 mucosal biopsies from 46 patients. From the total of 48 biopsies only 24 (50%) showed vascular anomalies. The most frequent lesion encountered was groups of thin‐walled dilated vessels in the lamina propria seen in 21 biopsies from 20 patients. These dilated vessels are not specific but in respect of age (median 69 years), location (predominantly in the caecum and the ascending colon) and frequent multiplicity, they are suggestive of angiodysplasia. Five of the 20 patients suffered from chronic anaemia due to haemorrhages. The three other positive biopsies (from two patients) revealed a tiny haemangioma in the sigmoid colon of a 28‐year‐old woman and a few large, thick‐walled probably malformed vessels in the mucosa of the caecum of a 17‐year‐old boy. Twenty‐four biopsies did not show any histologically significant vascular anomaly. Mucosal biopsy of vascular lesions detected during routine colonoscopic examination will, if positive, most frequently simply confirm the endoscopically diagnosed vascular ectasia and may in rare cases show or alert suspicion to vascular lesions other than angiodysplasia. Definitive morphological diagnosis will however only rarely be achieved by this method of

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02844.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

A review of a series of 226 melanomas, representing 95% of the melanomas presenting in one year, has shown that 34% are associated with atypical melanocytic proliferation or melanocytic dysplasia in the adjacent skin. The dysplasia may be lentiginous, predominantly spindle‐celled or non‐lentiginous in pattern. These variants appear to correspond to the previously reported lesions, lentiginous and epithelioid melanocytic dysplasia and atypical melanocytic hyperplasia respectively. Some of these are referred to as dysplastic naevi. All these variants were seen in a review of 325 cases of melanocytic dysplasia. The variations are commonly seen within the same lesion and it is argued that they are variants of a single premalignant process which might best be termed melanocytic dysplasia. Melanocytic dysplasia is seen in white races, on non‐exposed and exposed skin. They may be solitary as well as multiple and the majority are non‐familial. Although melanocytic dysplasia may be a precursor of a large proportion of malignant melanomas it is suggested that most lesions mature into a benign intradermal melanonaevus. The behaviour of the lesions in any single patient appears to be proportional to the number and cellularity of the lesions and the strength of the family history. A diffuse mottled pattern of melanocytic dysplasia appears to have a particularly unfavourable pr

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02845.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

A patient with mycosis fungoides is described in whom two excised epidermoid cysts showed mycotic involvement.

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02846.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02847.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02848.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02849.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02850.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY