摘要:

The normal lymph node comprises a superficial cortex, a deep cortex or paracortex and a medulla. In each of these regions there are three kinds of spaces: an intralymphatic space, an intravascular space and an extravascular space or interstitium. Both the vascular endothelium and the lymphatic endothelium are specialized in these different regions. The cell types in lymph nodes comprise lymphoid cells, accessory or non‐lymphoid cells and stromal cells, and within these cell types a number of different sub‐types can now be identified by means of enzyme‐ and immunocytochemistry. Based predominantly on experimental studies, the origin, migratory patterns, localization, inter‐relationships and interactions between these various cells are r

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02830.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

In order to test the reproducibility of a histomorphometrical grading system of bladder tumours, 15 tumours were twice measured independently by three pathologists. The data obtained were then analysed and compared with that of histological grading only. The way in which these morphometrical results are presented to the clinician in a computerized report is described. The need for a satisfactory reliable reproducibility test of every histomorphometrical grading system before introduction in diagnostic pathology is discussed.

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02831.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

Nuclear morphometry has been studied by a simple visual method in order to obtain an objective criterion for distinguishing epitheliosis from intraduct carcinoma in tissue sections. Nuclear area was found to be superior to the measurement of major or minor axes. Estimated area (major x minor axes), although less accurate than measured area, gave equally good discrimination. The best discrimination was obtained using the differences between the mean estimated nuclear area of the diseased duct and a normal duct in the same section. Using a difference of 20μm2as the dividing line, epitheliosis and intraduct carcinoma could be correctly classified by this criterion alone in 86% of the lesions studied

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02832.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

A series of 20 cases of radiation bowel disease (RBD) was studied qualitatively and the arterial changes were studied quantitatively. A control series of 45 cases was studied. In the control cases there were positive correlations between the medial thickness of all vessels studied and the diastolic blood pressure as well as the incidence of intimal fibrosis in both intramural and extramural arteries. The medial thickness in all the arteries in cases of RBD was significantly higher than in the controls. This was probably due to the large number of fibrin thrombi which increased the vascular resistance. The degree of intimal fibrosis of the intramural arteries and arterioles was significantly greater than in the controls. Similarly the incidence of intimal fibrosis in all arterioles and intramural arteries was greater than the control group. The degree of intimal fibrosis was related to the dose of radiation received. The effect of radiation was an on‐going process since the percentage of arterioles with intimal fibrosis increased with the time after radiotherapy. Blood pressure and age played no part in these correlations in RBD. The most consistently observed qualitative changes in RBD were in the arteries, arterioles and to a lesser extent the veins. These showed fibrin thrombi, fibrinoid necrosis, subendothelial oedema and fibrin. Various stages of healing were seen in the vessels. We believe that the blood vessels are the main site of injury in RBD and that the endothelial cell is the initial target for radiation damag

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02833.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

The variation between three pathologists examining histological features seen in non‐neoplastic colonic mucosa from 40 biopsies was analysed. Several procedures to express observer variation were used and compared, with emphasis on kappa statistics. Only five features, the presence of ulceration, villous surface, epithelioid granulomas, severe mucus depletion and crypt abscesses were sufficiently reproducible by the three pairs of pathologists. These findings suggest that other criteria used for the classification of inflammatory bowel disease are potentially unsatisfactory. When results from different studies on biopsies are being compared, influence of observer variation should be identified. Comparison of statistical techniques showed overall variation to be less useful than other statistical procedures. There was little difference between results from kappa statistics and other measures of agreement (overall agreement excluded

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02834.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

This study of thirteen cases of chordoma serves to emphasize the occurrence of three different histological patterns; classical, seven; chondroid, three; and intermediate or mesenchymal, three. The study also suggests that more adequate sampling of these tumours detects the chondroid variant more readily. These varying patterns of differentiation in tumours of notochordal origin suggest that the parent tissue may have the potential to develop along similar lines in the embryo. Thus mesenchymal and cartilaginous tissue formed from notochordal cells could contribute to the formation of the nucleus pulposus and inner portion of the intervertebral disc cartilages. This concept contrasts with the previously held view that the notochord atrophies at an early stage in embryonic development.

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02835.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

Three cases showing focal intestinal metaplasia of the endocervical glands are presented. The intestinal‐type epithelium contained absorptive cells, goblet cells and argentaffin cells, and resembled that found in intestinal types of mucinous ovarian tumours. Two of the cases were associated with squamous cell carcinoma‐in‐situ (CIN III), and both of these also showed borderline glandular malig

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02836.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02837.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02839.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02840.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY