ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1988.tb02034.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1988.tb02035.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

This essay examines critically the concept of ‘dysplasia’ as it applies to melanocytic neoplasia and concludes that the concept is flawed. Doubt is cast also upon the validity of the concepts of a dysplastic naevus and a dysplastic naevus syndrome. The author is of the view that most malignant melanomas arisede novoand not in pre‐existing dysplastic naevi. Because so‐called dysplastic naevi are considered by the author to be the commonest melanocytic naevi in man and devoid of nuclear atypia, he proposes that they be re‐named ‘common naevi’ in the interest of symplicity, accuracy, and care of patients. Lastly, it is suggested that resolution of problems in the sphere of melanocytic neoplasia might be accomplished more readily were terms like dysplasia, dysplastic cells, dysplastic naevi, and the dysplastic naevus synd

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1988.tb02036.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

The production and characterization of a new monoclonal antibody, Y2/51, against platelet glycoprotein IIIa is described. A useful feature of this antibody is its ability to recognize platelets and megakaryocytes in formalin‐fixed routinely processed material. It could also be used to reveal platelets both in thrombi in large vessels and in microthrombi too small to be readily apparent on conventional microscopic examination. For this purpose it was helpful to use the antibody in conjunction with a new monoclonal reagent (Ret40f) against red cell sialoglycoprotein β‐which detects red cells and their precursors in routinely processed tissue. The use of these antibodies should be valuable for the detection of thrombi in a variety of situations such as renal transplant rejection, coronary artery disease and vascul

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1988.tb02037.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

The microscopic anatomy of the oesophago‐gastric territory is interpreted as the result of the interaction of three main phenotypes: squamous, oxyntic and intestinal. This synthesis allows the comparison between phenotype development, atrophy and metaplasia. The concomitances in the processes of development and repair lead to the proposal of an intestinalization gradient inherent to the oesophago‐gastric field. This hypothesis permits an integration of the epithelial changes associated with gastritis and oesophagitis together with ontogenesis. The global tendencies in epithelial development and repair are discussed; a link between the two appears evident. The shifting potential of the progenitor gland zones in development and repair is in consonance with Wolpert's theory of positional informat

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1988.tb02038.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Two patients receiving gold therapy for rheumatoid arthritis developed skin pigmentation, chrysiasis, which in one appeared 4 months after cessation of the therapy. The diagnosis was confirmed by transmission electron microscopy and mass spectrometry laser microprobe analysis of paraffin sections and its extent demonstrated by epipolarized light. The condition is poorly reported and clinically may be confused with silver and mercury impregnation. Tissue diagnosis requires ancillary methods and of these, transmission electron microscopy and laser microprobe mass spectrometry are excellent examples. The transmission electron microscopy findings differ from previous reports and raise doubts on the hypothesis on the role of the skin in gold excretion. Because of the renewed interest in crysotherapy and the latent period that can separate this from chrysiasis, an increase in chrysiasis and the need for its diagnosis can be anticipated.

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1988.tb02039.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

The aims of the study were to (1) determine the histopathology of parathyroid autografts in patients with renal failure treated by parathyroidectomy, (2) relate this to any evidence of hyperfunction, such as histological osteitis fibrosa and (3) determine whether there were any features in the donor parathyroid glands which correlated with autograft behaviour. Fourteen patients were studied; 106 implanted parathyroid fragments were identified in nine at necropsy and in the remaining five patients multiple fragments were obtained at the time of autograft surgical reduction. Of the patients studied at necropsy, in two the autografts were small and hypofunctional and in one of these the implants appeared partially involuted. In neither was there osteitis fibrosa. In the others there were varying degrees of hyperplasia and osteitis fibrosa. Four of the surgically excised autografts were markedly hyperplastic but there was no unequivocal evidence of malignancy. In one case, requiring repeated reduction of rapidly growing autograft tissue, there were frequent mitoses in the donor parathyroid gland and in the autograft. The presence of atypical cellular features and frequent mitoses in intra‐operative frozen sections of a parathyroid gland militate against its use for implantatio

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1988.tb02040.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Penicillium marneffeiis a rare human pathogen that often causes problems in clinical and histological diagnosis. A patient who presented with autoimmune haemolytic anaemia and hepatosplenomegaly, and was subsequently found to be suffering from disseminatedPenicillium marneffeiinfection, is reported. The liver biopsy showed epithelioid cell granulomas only, and tuberculosis was initially considered the most likely diagnosis. The correct diagnosis became evident in a subsequent colonic biopsy, which showed extensive infiltration by penicillium‐laden macrophage

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1988.tb02041.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Light and electron microscopic studies of 14 cases of collagenous colitis are reported. Comparative electron microscopic examinations were carried out on 13 cases of ulcerative colitis in the chronic fibrotic stage of the disease. Separation of pericryptal fibro‐blasts which showed enhanced fibre‐forming activity, proliferation of myofibroblasts, accumulation of mast cells and a pericapillary collagen accumulation were noted in both groups. Based on these results, collagenous colitis was considered to result from scar formation secondary to previous superficial inflammat

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1988.tb02042.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Eleven resected primary lung carcinomas classified as large cell carcinomas or squamous cell carcinomas, but showing some microscopic resemblances to bronchial carcinoid and small cell carcinoma, were studied. All cases were neurone‐specific enolase and protein gene product 9.5 positive, indicating neuroendocrine differentiation. Staining for bombesin, C‐terminal peptide of human pro‐bombesin and chromogranin was positive in some cases. Electron microscopy showed dense‐core granules in six of seven cases investigated, the remaining case showing small granules of uncertain nature. All but one patient died within 15 months after operation. These data indicate that neuroendocrine differentiation in non‐small cell carcinomas of the lung may in some cases be suspected on routine histology. The follow‐up data suggest that the identification of these cases might have implications for prognosis and therapy, and consequently for diagnostic lung tumour cla

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1988.tb02043.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY