摘要:

Evidence suggests that in susceptible individuals lymphocytic myocarditis is a virus‐induced autoimmune disease which may progress to dilated cardiomyopathy. Its biopsy pathology, the application of the ‘Dallas’ criteria for diagnosis and the role of immunohistochemistry are discussed. The potential role forin situhybridization in the detection of viral genomes is referred to. Pathogenesis may be related to persistence of viral RNA in tissues and may involve both cellular and humoral immune mechanisms. The effect may manifest itself at cellular level with myocytolysis or at sub‐cellular level with interference in energy production, giving rise to considerable functional deficit with few morphological

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1990.tb00707.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

Twenty cases of malignant lymphoma arising in the thyroid gland were studied clinically, histologically and immunohistochemically. Nineteen cases were non‐Hodgkin's lymphoma (15 diffuse and four follicular lymphoma) and one was a plasmacytoma. Immunohistochemical analysis of the lymphomas using paraffin‐embedded sections disclosed that 17 lymphomas were B‐cell type and two were T‐cell type. The plasmacytoma was of IgG kappa type. The large majority of the lymphomas were associated with an underlying chronic thyroiditis. The 5‐year survival rate of the patients was 70%. An unfavourable diagnosis was more likely when the tumour was diffuse rather than follicular, when it was of diffuse large cell type or of immunoblastic type and when there was cervical lymph node in

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1990.tb00708.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

The CD30 antigen has been reported as the immunophenotypic hallmark of a recently described category of non‐Hodgkin's lymphoma, termed anaplastic large cell lymphoma. From a series of approximately 500 lymphomas, 17 cases showing typical anaplastic features have been identified. They were strongly labelled by monoclonal antibodies recognizing CD30 (Ki‐1 or BerH2). However, 36 other lymphomas, mainly high‐grade, of non‐anaplastic cytology also expressed CD30, either diffusely or focally, with a staining pattern identical to that seen in anaplastic large cell lymphomas. This clearly suggests that such lymphomas cannot be identified solely on the basis of being high‐grade non‐Hodgkin's lymphomas showing CD30 positivity. From the present results, the distinction between the anaplastic and non‐anaplastic types would be better made with antibodies to epithelial membrane antigen than to CD30. Clinical data, available for 48 of the patients (16 with anaplastic large cell lymphomas and 32 with non‐anaplastic) revealed no significant differences with regard to age at presentation, sex or clinical signs. A short‐term follow‐up study of 25 patients revealed that for the first 2 years after diagnosis there were no significant differences in patient survival between anaplastic large cell lymphoma, other CD30+ high‐grade lymphomas and all high‐grade non‐Hodgkin's lymphomas considered together. These findings, which must be confirmed by larger studies, suggest that in a general lymphoma clinic there is probably little justification for differentiating anaplastic large cell lymphomas or CD30+ lymphomas from other high‐gr

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1990.tb00709.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

We report a case of intestinal metaplasia of the bladder urothelium associated with dysplastic foci and a transitional cell carcinoma. A mixture of sialomucins,O‐acetylated sialomucins and sulphomucins was found in the goblet cells. Neuraminidase resistant binding of the lectin peanut agglutinin was demonstrated in the brush border of columnar cells in intestinal metaplasia and diffusely in columnar cells in dysplastic foci. The histochemical findings are compared with those described in normal, dysplastic and neoplastic colonic mucos

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1990.tb00710.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

Biopsy and autopsy material from the urinary bladder was studied using PAS and PAS‐D techniques to identify glycogen and neutral mucins, the alcian blue/high iron diamine method to distinguish sialo‐ and sulphamucins and the PB/KOH/PAS technique to localizeO‐acylated sialomucins. All of 10 examples of normal urothelium and both of two cases of transitional carcinomain situcontained glycogen, but no mucin. Other lesions displayed one of two patterns of mucin production: the extracellular mucin seen focally in 17 cases of cystitis cystica consisted of sialo‐ and/or neutral mucins only, a pattern also displayed by mucins produced in 10 of 13 examples of transitional cell carcinomas and by three of nine tumours purely or in part adenocarcinomas. The intracellular mucins expressed in five of the 17 cases of cystitis glandularis and in all of eight cases of frank intestinal metaplasia with goblet cells displayed a colonic phenotype, with production ofO‐acylated sialomucins. A similar profile was expressed by six adenocarcinomas and this included tumours likely to be of vesical and also of urachal origin. It is concluded that identification ofO‐acylated mucins cannot distinguish between primary bladder tumours and metastases from a colonic primary, or between carcinomas of vesical and ura

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1990.tb00711.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

The immunohistochemical localization of copper, zinc‐superoxide dismutase (Cu, Zn‐SOD) in human gastric mucosa and gastric cancer was studied using a monoclonal antibody. In gastric mucosa, parietal cells, pyloric glandular cells and foci of intestinal metaplasia showed positive staining in the cytoplasm and/or nucleus. The wide distribution of Cu, Zn‐SOD in the gastric mucosa suggests cell function may be vulnerable to active oxygen species. In gastric cancer, 34 of 70 cases showed a positive reaction for Cu, Zn‐SOD. There was a relationship between the grade of Cu, Zn‐SOD immunoreactivity and the histological type of gastric cancer, well‐differentiated types of gastric cancer being more frequently positive. The positive cases of poorly‐differentiated adenocarcinoma were characterized by a pattern of diffusely infiltrative invasion. These results suggest that some types of gastric cancer are resistant to active o

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1990.tb00712.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

The immunoreactivity of a new monoclonal antibody to endothelium, QBEND/10, in formalin‐fixed, paraffin‐embedded sections from a variety of vascular and lympotic tumours is described and compared to that of two other endothelial markers, von Willebrand factor andUlex europaeusagglutinin, type 1. All the benign tumours of blood vascular origin showed immunoreactivity whereas only five out of eight lymphangiomas demonstrated a weak focal reaction with QBEND/10. Primitive lumina in epithelioid and spindle cell haemangioendotheliomas were highlighted in all the cases. Tumour cells in angiosarcoma forming vasoformative areas and solid areas showed immunopositivity to QBEND/10 in 17/23 and 13/24 cases respectively, and complementary immunoreactivity for von Willebrand factor was observed. Proliferating vessels and the majority of spindle cells in Kaposi's sarcoma were positive in all 40 cases. Only one of 54 cases of carcinoma showed luminal reaction to QBEND/10. However, 17 of 45 spindle cell tumours displayed a positive reaction. QBEND/10 is an additional marker for demonstrating endothelial differentiation and has some advantages over currently available antibod

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1990.tb00713.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

Over‐expression of the c‐erbB‐2 oncogene occurs in a proportion of human adenocarcinomas and in breast carcinoma is associated with poorer prognosis. Sections of formalin‐fixed, paraffin‐embedded tumour tissue from 22 patients with mammary and extramammary Paget's disease have been stained immunohistochemically using a monoclonal antibody (NCL‐CB11) raised against a synthetic peptide from the C‐terminal end of the predicted equence of the c‐erbB‐2 protein product. All 12 cases of mammary Paget's disease showed membrane staining of intra‐epidermal cells, indicating c‐erbB‐2 over‐expression. Sections of underlying ductal breast carcinoma were available in nine cases; all nine tumours were c‐erbB‐2 positive and in eight thein situcomponent was of comedo or solid type. There was membrane staining of tumour cells in four of the 10 cases of extramammary Paget's disease; staining intensity was generally weaker than that observed in the cases of mammary disease. The possible implications of these findings for the histogenesis of both mammary and extramammary

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1990.tb00714.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

Atypical stromal cells were identified in either the cervix or vagina in 27 (13%) of 205 autopsy specimens. They were more commonly observed in the vulva, occurring in 29 (78.4%) of 37 vulvar surgical specimens. In only seven patients were the cells present as a continuous band: five in cervix or vagina and two in vulva. Electronmicroscopic examination confirmed the fibro‐blastic nature of these cells. Although hormonal influences may be responsible for this stromal alteration, their occurrence in elderly patients and in males at other sites is not consistent with a specific hormonal profile. It is important not to misdiagnose these cells as malignan

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1990.tb00715.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

A case of signet‐ring cell carcinoid of the gallbladder is reported. The tumour diffusely infiltrated the gallbladder wall and extensively ulcerated the mucosa. Neoplastic nests were composed of numerous signet‐ring cells mixed with clear endocrine cells. The latter expressed chromogranin A, gastrin and somatostatin and contained neurosecretory granules. The diagnostic problem of differentiating between signet‐ring cell carcinomas and composite adenocarcinoma‐carcinoid tumours is di

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1990.tb00716.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY