ISSN:1015-3837    

DOI:10.1159/000318670

出版商:S. Karger AG    

年代:1993

数据来源: Karger

摘要:

In order to elucidate the effects of corticosteroids on fetal hearts during midtrimester, pregnant rats were injected with a daily dose of betamethasone (1 mg/kg) from the 12th day through the 17th day of pregnancy. The fetal cardiovascular and pulmonary systems were studied on the 21 st day of pregnancy (term). The treated fetuses showed the following signs of hydrops fetalis: retarded growth, pale, edematous skin, and decreased movement. The thymus and lung displayed prominent hypoplasia. The morphometry of the treated fetuses revealed: decreased right ventricle mass by 37% and decreased left ventricle mass by 29 %. We concluded betamethasone had a significant effect on the developing fetal cardiovascular system, inducing hydrops fetalis. Additionally, betamethasone caused hypoplasia of the thymus and lung

ISSN:1015-3837    

DOI:10.1159/000263754

出版商:S. Karger AG    

年代:1993

数据来源: Karger

摘要:

Separation of fetal cells from maternal blood could provide a means for prenatal diagnosis that would not endanger the fetus. In this pursuit, we attempted cytogenetic analysis of candidate fetal cells flow sorted on the basis of parental HLA disparity. Metaphases showing 46, XY or aneuploidy and concordant with prenatal diagnostic studies (i.e., amniocentesis, chorionic villus sampling) would presumably be fetal in origin. Blood samples were obtained from 78 pregnant women and their partners. Among 18 HLA informative cases in which metaphases were recovered, 15 involved fetuses that were 46, XY or aneuploid. From these 15 cases, 2,483 metaphases were analyzed. All metaphases were 46, XX. Cytogenetic analysis of flow-sorted fetal cells thus probably will need to emphasize not metaphase analysis but in situ hybridization with chromosome-specific probes.

ISSN:1015-3837    

DOI:10.1159/000263755

出版商:S. Karger AG    

年代:1993

数据来源: Karger

ISSN:1015-3837    

DOI:10.1159/000263898

出版商:S. Karger AG    

年代:1993

数据来源: Karger

摘要:

Increasing utilization of chorionic villus sampling (CVS) has lead to the discovery that the placenta can karyotypically be a very heterogenous organ, and chromosomal mosaicism within the placenta can confuse cytogenetic interpretation. Recently, confined placental mosaicism (confined regions of aneuploidy in the otherwise normal diploid placenta and fetus) has been described involving a number of chromosomal abnormalities. Fetal trisomy 16 is considered uniformly lethal early in gestation. However, we present 3 cases of nonmosaic trisomy 16 confined regionally to the placenta. We discuss the possible etiology, impact on the developing fetus, and suggest an approach to the workup and evaluation of cases where the karyotype obtained on CVS is not compatible with the findings on ultrasound.

ISSN:1015-3837    

DOI:10.1159/000263756

出版商:S. Karger AG    

年代:1993

数据来源: Karger

摘要:

Fetal hypoxemia is one of the most frequent causes of intrauterine growth retardation (IUGR). In chronic fetal hypoxia, peripheral blood flow and blood flow to the kidneys is reduced to maintain heart, brain and adrenal perfusion, the ‘brain-sparing effect’. In kidneys the cells of the proximal tubules seem to be most sensitive to hypoxia caused by reduced blood flow. Damage to the cells of the proximal tubules can be easily diagnosed by urinary levels of N-acetyl-β-D-glucosaminidase (NAG), an enzyme present in high concentrations in these cells. The aim of the present study was to define the levels of NAG in the amniotic fluid, to diagnose damage to the cells of the proximal renal tubules in fetuses, and to correlate them with a detectable brain-sparing effect. The study was conducted on a total of 55 pregnancies: 9 pregnancies were complicated by IUGR, and the remaining 46 normal pregnancies formed the control group. Higher levels of NAG were detected in the amniotic fluid from the IUGR-complicated pregnancies (p < 0.025). In particular, fetuses with IUGR had high levels of NAG in the amniotic fluid in 8 of 9 cases (+ 2 SD compared with controls), while 1 had normal concentrations. In the 8 cases with high concentrations of NAG in the amniotic fluid, velocimetric Doppler study documented a brain-sparing effect, which was not present in the 1 fetus with normal NAG levels. In conclusion, high levels of NAG in the amniotic fluid may identify in uterus fetuses with renal damage. These individuals are in need of stricter peri- and postnatal care as, in the case of perinatal anoxia, this particular condition may be one of the causes concurrent in the onset of postnatal acute renal fai

ISSN:1015-3837    

DOI:10.1159/000263757

出版商:S. Karger AG    

年代:1993

数据来源: Karger

摘要:

Ultrasonographic examination on a fetus at 24 weeks of gestation revealed an intrathoracic cystic mass with fetal hydrops and polyhydramnios. Pathological findings obtained at autopsy which was conducted on the fetus at 28 weeks indicated a typical congenital cystic adenomatoid malformation (CCAM) of the lung. The differential diagnosis and possible intrauterine treatment for lung CCAM are discussed.

ISSN:1015-3837    

DOI:10.1159/000263758

出版商:S. Karger AG    

年代:1993

数据来源: Karger

摘要:

Diabetes, whether or not it is insulin deficient, is frequently associated with vascular complications during pregnancy. It is accepted nowadays that the uterine artery velocity waveform is predictive concerning pregnancy-induced hypertension (PIH) and its complications. It thus seemed interesting to analyse the predictivity of vascular complications of diabetes by using uterine artery velocity waveforms. We have thus explored 37 diabetic patients [group 1: insulin-deficient diabetes (IDD), n = 10; group 2: gestational IDD, n = 6; and gestational non-IDD, n = 21). We have found vascular complications for 10 patients, divided between all 2 groups: 2 preeclampsia, 2 fetal suffering before any labour, 2 cases of intra-uterine growth retardation (including a trisomy 18) and 5 PIH. The uterine artery velocimetry measurement has been found to be pathological 5 times, and always in patients who later developed vascular complications. Among this selected population and excluding the trisomy 18, the sensitivity is of 44.5%, the specificity of 100%, the positive predictive value of 100%, and the negative predictive value of 84.3 %. If these results are confirmed, this examination could be an excellent marker of the vascular risk and thus would have its place during systematic survey of pregnancies complicated by diabetes.

ISSN:1015-3837    

DOI:10.1159/000263759

出版商:S. Karger AG    

年代:1993

数据来源: Karger

摘要:

Cerebral hemorrhages are the most serious complication in preterm and hypotrophic neonates. The mechanisms underlying the formation of these hemorrhages are unclear. In utero Doppler cerebral velocimetry is not yet used as a parameter to predict this complication. Our case allowed us to analyze the evolution of cerebral Doppler abnormalities with the appearance of an intracerebral hemorrhage. The modifications in the Doppler cerebral velocimetry could not be predicted. Therefore it is necessary to determine other parameters which show the evolution of the intracerebral vasomotricity.

ISSN:1015-3837    

DOI:10.1159/000263760

出版商:S. Karger AG    

年代:1993

数据来源: Karger

摘要:

Pregnancy during familial Mediterranean fever complicated with amyloidosis and severe nephrotic syndrome is rare and may cause several maternal and fetal complications. Asymmetrical intrauterine growth retardation, superimposed pre-eclampsia, thromboembolic phenomena, resistant anemia and renal failure only partially represent the possible complications. A successful outcome of a full-term pregnancy is presented and the efficiency of colchicine, a high protein diet, acetylsalicylic acid and dipyridamole is discussed.

ISSN:1015-3837    

DOI:10.1159/000263761

出版商:S. Karger AG    

年代:1993

数据来源: Karger