摘要:

This report describes 3 successive cases in which fetomatemal hemorrhage was suspected but confirmed in only 2. The manifestations of fetomatemal hemorrhage are often nonspecific and diagnosis can be difficult. We discuss diagnostic methods, especially the value of the Kleihauer-Betke test and maternal serum alpha-fetoprotein measurement, and approach.

ISSN:1015-3837    

DOI:10.1159/000264192

出版商:S. Karger AG    

年代:1995

数据来源: Karger

摘要:

In order to determine the frequency of associated malformations and chromosomal defects in patients with congenital diaphragmatic hernia (CDH) our experiences with CDH during the last 8 years (1985–1993) were reviewed. During the study period, 33 fetuses (prenatal group) with CDH were examined at our level III ultrasound department. In the same period 11 neonates (postnatal group) were admitted to our pediatric surgical unit after postnatal diagnosis of a CDH. Those cases had not been suspicious for CDH during prenatal level I scan. In 24 (72.7%) of the cases with CDH seen prenatally, at least one or more extradiaphragmatic malformations could be detected. Most of them affected the cardiovascular, skeletal, genitourinary and nervous system. Six (18.1%) fetuses had chromosomal abnormalities, especially trisomy 18. In contrast to these findings just 4 of the 11 babies (36.3%) seen postnatally had associated malformations and all of them had a normal chromosome set. Survival rate of fetuses with CDH and associated anomalies (7.1 %) was poor, in contrast to those with an isolated CDH (43.7%). Prenatal ultrasound investigations being suspect for CDH should encourage the clinician to make further diagnostical efforts. This includes detailed ultrasound examination and cytogenetic analysis. Associated malformations as well as chromosomal defects are often present in affected patient

ISSN:1015-3837    

DOI:10.1159/000264193

出版商:S. Karger AG    

年代:1995

数据来源: Karger

摘要:

The amniotic fluid cells of 2 patients with rubella at the 18th week of pregnancy were obtained during therapeutic abortion and examined with a transmission and a scanning electron microscope (SEM). In comparison with amniocytes of healthy women, those of rubella patients showed marked alterations, consisting of lack of heterochromatin, almost complete disappearance of the electrondense cytoplasmic layer and membrane changes. The membrane damage was clearly demonstrated by SEM and was expressed by a decrease in the number and size of microvilli. Although more experience is needed for evaluation of the ultrastructure of the amniotic fluid cells in rubella patients, these findings may serve as an additional tool for the intrauterine diagnosis of rubella.

ISSN:1015-3837    

DOI:10.1159/000264194

出版商:S. Karger AG    

年代:1995

数据来源: Karger

摘要:

Coelomic fluid (n = 32), amniotic fluid (n = 26) and placental tissue were obtained from 32 women undergoing termination of pregnancy at 7–11 weeks of gestation. Fluorescence in situ hybridisation (FISH) was performed to determine fetal sex using a heterochromatic Y probe and an alpha satellite repeat probe for chromosome X. In each case there was concordance in the fetal sex from the three compartments. However, no result could be obtained from 4 of the 32 coelomic fluids and 4 of the 26 amniotic fluid samples. The hybridisation efficiency was significantly lower in coelomic and amniotic fluid compared with placental tissu

ISSN:1015-3837    

DOI:10.1159/000264195

出版商:S. Karger AG    

年代:1995

数据来源: Karger