摘要:

The mutagenicity of halothane was tested In an <in-vitromicrobial assay system employing two histidine-dependent mutants of Salmonella typhimurium, TA9S and TA100. Halothane in concentrations ranging from 0.1 to 30 per cent was incubated with bacteria in the presence or absence of a metabolic activation system prepared from either nit liver treated with Aroclur 1254 or human liver. Trifluoroacelic acid, a major metabolite of halothane, and urine from patients anesthetized with halothane also were tested. Halothane, trifluoroacetic acid, and patients* urines were not mutagenic.

ISSN:0003-3022    

出版商:OVID    

年代:1976

数据来源: OVID

ISSN:0003-3022    

出版商:OVID    

年代:1976

数据来源: OVID

摘要:

The effects of diazepam on cerebral blood How (CBF) and cerebral oxygen uptake(CMRo2) was studied using a 133xenon modification of the Kety— Schmidt (1948) technique in paralyzed, artificially ventilated nits with and without simultaneous administration of 70 per cent nitrous oxide. Diazepam was given iv in doses that induced light to heavy sedation or general anesthesia. When given with 70 per cent nitrous oxide, diazepam in sedative and anesthetic doses lowered CBF and CMRo2to about GO per cent of control. In the absence of nitrous oxide all doses of diazepam caused moderate (20–30 percent) decreases in CBF, but CMRo2remained unchanged or was only slightly lowered. It is concluded that diazepam interacts with nitrous oxide to produce a reduction in CMRo2similar to that seen in barbiturate anesthesia, but that alone the drug produces sedation and anesthesia without a comparable decrease in CMRo2.

ISSN:0003-3022    

出版商:OVID    

年代:1976

数据来源: OVID

ISSN:0003-3022    

出版商:OVID    

年代:1976

数据来源: OVID

摘要:

The cardiovascular effects of halothane-nitrous oxide anesthesia, and beta-receptor blockade with either propranolol or practolol, were studied in 15 dogs in which severe myocardial infarction had been induced ten days earlier. The hemodynamic responses to blood loss amounting to 25 per cent of estimated blood volume, and its subsequent replacement, were studied before and after induction of beta-receptor blockade. In terms of cardiac output and aortic blood (low acceleration, cardiac performance in the absence of beta-blockade was markedly impaired during steady-state anesthesia, compared with corresponding values in normal dogs. Practolol (2.0 mg/kg) administered during anesthesia induced no significant circulatory change other than a 14 per cent decrease in heart rate and a 25 per cent increase in stroke volume. Propranolol (0.3 mg/kg) caused a comparable reduction of heart rate, but significantly reduced cardiac output (-27 per cent), aortic blood (low acceleration (-26 per cent), and peak L.V power (-19 per cent), and increased systemic vascular resistance (+49 per cent). The two drugs caused comparable shifts of the isoproterenol dose-response curve during anesthesia. Graduated blood loss during anesthesia, to a total of 25 per cent of blood volume, caused consistent circulatory changes (decreased mean arterial pressure, cardiac output, peak LV power, LV minute work) that were essentially similar before and after beta-receptor blockade with either propranolol or practolol. The positive inotropic effect of calcium gluconate during halo thane anesthesia was significantly reduced following either propranolol or practolol, but the hemodynamic responses to changes of systemic vascular resistance induced with acetylcholine or phenylephrine were not modified by beta-receptor blockade.

ISSN:0003-3022    

出版商:OVID    

年代:1976

数据来源: OVID

ISSN:0003-3022    

出版商:OVID    

年代:1976

数据来源: OVID

ISSN:0003-3022    

出版商:OVID    

年代:1976

数据来源: OVID

摘要:

An inexpensive modification to the stopcock of a conventional gas-sampling bulb permits convenient preparation of standards for gas chromatography.

ISSN:0003-3022    

出版商:OVID    

年代:1976

数据来源: OVID

ISSN:0003-3022    

出版商:OVID    

年代:1976

数据来源: OVID

ISSN:0003-3022    

出版商:OVID    

年代:1976

数据来源: OVID