ISSN:0003-3022    

出版商:OVID    

年代:1976

数据来源: OVID

摘要:

Localized edema follows the freezing of a small area of cerebral cortex. Effects of five subsequent hours of anesthesia on this edema were studied in six groups of six dogs each. Six anesthetic techniques were studied. In six additional “awake” dogs, anesthesia (halothane) was discontinued immediately after the lesion was made. Eight control dogs received neither anesthesia nor cryogenic injury. Control white matter contained 67.4 = .4 (mean = SE) per cent water by weight. Twenty-four hours after the cryogenic injury water accounted for the following percentages of total weight of white matter adjacent to the lesion: 60 mg/kg pentobarbital. 73.2 = .9; 70 per cent N2O/Innovar, 73.6 = .9; “awake”. 77.9 = .9; 1.95 per cent enflurane. 78.2 = .9: 1.33 per cent iso-flurane. 78.6 = .8; 0.86 per cent halothane, 78.2 = .6; 1.89 per cent halothane, 79.7 = .6 Peak intracranial pressures (ICP) were 15.4 = 1.3 torr with pentobarbital. 21.6 = 1.8 torr with N2O /In-novar, and 31.1 = 2.6 to 38.3 = 45 torr with the halogenated anesthetics. The water content of white matter and ICP were significantly lower (P< 0.05) in animals receiving pentobarbital or N2O /Innovar anesthesia than in animals receiving inhalation anesthetics. The authors conclude that pentobarbital and fentanyl-droperidol (Innovar) limit the extent of cerebral edema, but that inhaled anesthetics do not.

ISSN:0003-3022    

出版商:OVID    

年代:1976

数据来源: OVID

摘要:

Circulatory and respiratory effects of change of posture from sitting In supine were studied in 11 obese patients scheduled for gastric bypass operations. Patients were studied on the morning of operation before any medication was given. Average weight was 138.8 kg, 108.6 per cent above ideal weight. Change of posture from sitting to supine was associated with II per cent increase in oxygen consumption (Vo2, 35.5 per cent increase in cardiac output (CO)2, 35.8 per cent increase in cardiac index, 17.85 per cent decrease in arteriovenous oxygen difference, 31 per cent increase in mean pulmonary arterial pressure. 44 per cent increase in pulmonaryartery wedge pressure. 21.5 per cent decrease in peripheral resistance (PR), 6 per cent decrease in heart rate, and 17.7 per cent increase in venous admixture (Qs/QtAll these changes were significant. There was no change in mean arterial pressure, alveolo-arterial O2difference and respiratory rate. The increase in CO was attributed to reduction in PR and to increased V02probably due to increased work of breathing.

ISSN:0003-3022    

出版商:OVID    

年代:1976

数据来源: OVID

ISSN:0003-3022    

出版商:OVID    

年代:1976

数据来源: OVID

摘要:

Neuromuscular blockades induced by clindamycin alone and withd-tubocurarine or pancuronium were examined in thein-vitroguinea pig lumbrical muscle-nerve preparation. Clindamycin, 8O-240 μ/ml, initially increased twitch tension. With higher concentrations (180–240 μg/ml) twitch tension subsequently decreased. With 15 to 20 per cent depression of twitch tension by clindamycin. neostigmine (5–20 ng/ml) or calcium (81 μg/ml) slightly but not completely antagonized the blockade. Clindamycin, 40 μg/ml, a dose that did not depress twitch tension, potentiatedd-tubocurarine- or pancuronium-induced neuromuscular blockade. Plasma concentrations of clindamycin of 10–40 μg/ml are recommended for treating serious infections. The authors conclude that the administration of clindamycin may augment nondepolarizing blockade in man, and antagonism by neostigmine and calcium may be incomplete.

ISSN:0003-3022    

出版商:OVID    

年代:1976

数据来源: OVID

ISSN:0003-3022    

出版商:OVID    

年代:1976

数据来源: OVID

ISSN:0003-3022    

出版商:OVID    

年代:1976

数据来源: OVID

ISSN:0003-3022    

出版商:OVID    

年代:1976

数据来源: OVID

ISSN:0003-3022    

出版商:OVID    

年代:1976

数据来源: OVID

ISSN:0003-3022    

出版商:OVID    

年代:1976

数据来源: OVID