ISSN:0003-3022    

出版商:OVID    

年代:1971

数据来源: OVID

摘要:

Methoxyflurane was administered to eight healthy male volunteers over a three-hour period during which myocardial contractility, cardiac output, oxygen consumption, and total peripheral resistance were measured serially. Myocardial contractile force initially decreased, but returned toward control with time. Cardiac output remained unchanged. Total peripheral resistance, reduced at one hour in most cases, did not decrease further during the next two hours. Oxygen consumption remained directly related to cardiac output. It was concluded that some “adaptation” or “recovery” occurs when methoxyflurane is administered for an extended period, but recovery was not as marked as that observed with halothane.

ISSN:0003-3022    

出版商:OVID    

年代:1971

数据来源: OVID

ISSN:0003-3022    

出版商:OVID    

年代:1971

数据来源: OVID

摘要:

The effects of three beta-adrenergic stimulating agents, isoproterenol, salbutamol, and terbutaline, were studied in the cat. In animals receiving halopropane, the dose of salbutamol or terbutaline necessary to produce ventricular arrhythmias was 100-500 times greater than the dose of isoproterenol needed. In cats receiving nitrous oxide, a dose of carbachol which increased airway pressure 50-135 per cent for a preset tidal volume was given. This action of carbachol was blocked by 2 µg/kg of salbutamol or terbutaline. The large differences between bronchodilating and arrhythmia-producing doses of salbutamol and terbutaline suggest that these agents might be of value in the treatment of bronchoconstriction in conscious and anesthetized patients.

ISSN:0003-3022    

出版商:OVID    

年代:1971

数据来源: OVID

摘要:

Methoxyflurane reduced the total developed tensions of isolated guinea pig atria and isolated cat papillary muscle but did not change the rate of spontaneous beating of isolated atria. The staircase phenomenon and postextrasystolic potentiation appeared not to be affected when the increases in developed tension were expressed as percentages of the preceding values. These effects are similar to those reported for halothane. Unlike halothane, methoxyflurane did not produce significant changes in the increases of developed tension induced in papillary muscle by high-voltage electrical stimulation or tyramine or in the effective refractory period of papillary muscle.

ISSN:0003-3022    

出版商:OVID    

年代:1971

数据来源: OVID

ISSN:0003-3022    

出版商:OVID    

年代:1971

数据来源: OVID

摘要:

The antiarrhythmic effects ofd-tubocurarine, gallamine and succinylcholine were evaluated in mongrel dogs mechanically ventilated with nitrous oxide-oxygen. Arrhythmias were induced by intravenous administration of epinephrine. The severity and incidence of ventricular arrhythmias were significantly reduced by the muscle relaxants in comparison with thiopental. Repeated injections of epinephrine were less effective in producing ventricular arrhythmias while they continued to produce the same degree of pressor response. The results suggest that neuromuscular blocking drugs may protect against some types of ventricular arrhythmias.

ISSN:0003-3022    

出版商:OVID    

年代:1971

数据来源: OVID

ISSN:0003-3022    

出版商:OVID    

年代:1971

数据来源: OVID

摘要:

The interaction of diazepam with neuromuscular blocking agents was studied in patients and in several animal nerve-muscle preparations. This drug did not alter the recovery slope of blockade produced byd-tubocurarine, decamethonium, or gallamine. In higher doses diazepam produced a decrease in muscle contractions and blocked the actions of exogenously applied nicotine and acetylcholine in the superfused chick biventer cervicis nerve—muscle preparation. In low doses the commercially available drug given intra-arterially reversed the myoneural blockades produced by both depolarizing and nondepolarizing blockers. However, this property was due to the solvent system of the drug.

ISSN:0003-3022    

出版商:OVID    

年代:1971

数据来源: OVID

摘要:

Amnesia for the events occurring during surgical operations is a desirable feature of general anesthesia but is not always attained. Evidence from research on memory suggests that anesthetic amnesia results from 1) attenuation of sensory transmission and 2) impairment of the ensuing memory-consolidation process. In a few patients, however, auditory information of high emotional content, coinciding with a lightening of anesthesia, results in memory consolidation sufficient to permit unpleasant recall, spontaneously or under hypnosis. The physiologically desirable light levels of modern anesthesia impose the constraint of avoiding conversation in surgery that can result in psychologically undesirable memory traces.

ISSN:0003-3022    

出版商:OVID    

年代:1971

数据来源: OVID