摘要:

The time course of nitrous oxide analgesia was studied in rats with a behavioral criterion, the tail-flick test to radiant heat. All rats were placed individually in a Plexiglas® tube and exposed to either nitrous oxide, 75% in oxygen, or room air (control) for 2 hr. Analgesic potency was evaluated by prolongation of the time required to induce tail-flick. Although individual animals showed variability in the tail-flick time during exposure to nitrous oxide, no animal showed a tendency toward the development of tolerance, and a statistically significant sustained prolongation of tail-flick time was produced.

ISSN:0003-3022    

出版商:OVID    

年代:1985

数据来源: OVID

摘要:

The Edwards® lung water computer system uses the thermaldye indicator technique to estimate the lung extravascular fiuid volume (EVLW). The authors tested the effect of changes in cardiac output (CO) on EVLW estimates made with the lung water computer in six dogs anesthetized with halothane. Baseline CO was 2.5 ± 1.3 1/min (mean ± SD); CO subsequently was increased either by 220% or decreased by 70% by either giving 0.5 mg/kg of isoproterenol or increasing the inspired halothane (1–4%), respectively. There was a significant correlation between the estimated EVLW and CO in each animal (P< 0.05) such that a 50% decrease in CO from baseline caused an approximately 40% increase in estimated EVLW. Postmortem examination showed that the lungs were not edematous, even though the lung water computer data indicated that severe pulmonary edema had developed at reduced COs. At increased COs, estimated EVLW decreased. The authors conclude that the Edwards® lung water computer overestimtes lung water, possibly because the thermal indicator diffuses into nonpulmonary as well as pulmonary tissue. The overestimate is greatest at low cardiac outputs.

ISSN:0003-3022    

出版商:OVID    

年代:1985

数据来源: OVID

摘要:

Serum cholinesterase (E.C. 3.1.1.8) was assayed with succinylcholine as a substrate. The reaction was coupled with choline oxidase and peroxidase in the presence of 4-aminoantipyrine and phenol to produce a red quinone dye that was measured spectro-photometrically. The method requires 25 μl of sample in a total volume of 1.0 ml. The mean activity for 35 adults of the usual genotype was 74.4 ± 28 U/l (range 24–125 U/l). Succinylcholine-sensitive individuals had activities below 18 U/l. The same serum samples also were assayed with propionylthiocholine as a substrate. Activities with the two substrates showed a coefficient of correlation of 0.980 (n = 68). However, the method using propionylthiocholine showed more overlap between the activities of succinylcholine-sensitive and insensitive individuals. Assay with succinylcholine thus may offer a more effective method of screening for sensitive individuals, since some escape detection by conventional genotyping with dibucaine and fluoride.

ISSN:0003-3022    

出版商:OVID    

年代:1985

数据来源: OVID

ISSN:0003-3022    

出版商:OVID    

年代:1985

数据来源: OVID

ISSN:0003-3022    

出版商:OVID    

年代:1985

数据来源: OVID

ISSN:0003-3022    

出版商:OVID    

年代:1985

数据来源: OVID

ISSN:0003-3022    

出版商:OVID    

年代:1985

数据来源: OVID

ISSN:0003-3022    

出版商:OVID    

年代:1985

数据来源: OVID

ISSN:0003-3022    

出版商:OVID    

年代:1985

数据来源: OVID

ISSN:0003-3022    

出版商:OVID    

年代:1985

数据来源: OVID