ISSN:0003-3022    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

An experiment was performed to determine whether needles inserted into appropriate acupuncture points could delay onset of a pain-terminating response more than needles inserted as placebos into inappropriate points could. A heat source contained in a modified Hardy-Wolff-Goodell dolorimeter was used as a stimulus to Procedure produce pain on the posterolateral aspects of the left forearms of volunteer subjects. Subjects pressed a switch as soon as pain was experienced, and the latency between stimulus onset and response was measured to the nearest hundredth of a second. Response latencies were recorded before and after needling, which included electrical stimulation. Needles placed in specific acupuncture point called Ho-ku and Wai-Kuan delayed onset of the pain-terminating response slightly more than needles inserted as placebos. Even with needles in appropriate acupuncture points, analgesia was slight and subjects still experienced pain.

ISSN:0003-3022    

出版商:OVID    

年代:1975

数据来源: OVID

ISSN:0003-3022    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

Responses to electrical stimulation of the tooth pulp were obtained in both baseline and test sessions for subjects receiving acupuncture, 33 per cent nitrous oxide, or control conditions. A signal-detection analysis across sessions showed that both treatment groups demonstrated reduced sensitivity to stimulation, and increases in bias against reporting strong stimuli as painful.

ISSN:0003-3022    

出版商:OVID    

年代:1975

数据来源: OVID

ISSN:0003-3022    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

Ten consecutive adult patients undergoing elective cardiac surgery with extracorporeal circulation were anesthetized using morphine (1–3 mg/kg) and nitrous oxide. Pre-bypass plasma renin activity showed a 3.3-fold elevation (P < 0.001) over baseline values. This correlated with maximal blood pressure elevation. Plasma renin activity remained elevated during bypass. High baseline aldosterone levels increased 3.4-fold (P < 0.001) after 15 minutes on bypass and 4.0-fold by the end of bypass. Plasma potassium decreased from 3.9 mEq/1 before bypass to 3.2 mEq/1 (P < 0.001) during bypass, and the fractional urinary- excretion of potassium was 32 per cent before bypass with a mean of 34.4 per cent during bypass. Urinary output remained high during bypass despite a progressive decrease in glomerular filtration rate. Catecholamine levels showed no significant change. The data suggest that the renin-angiotensin-aldosterone system may play a role in blood pressure regulation during cardiopulmonary bypass and may result in the excessive urinary excretion of potassium and decrease in plasma a decrease in plasma potassium levels.

ISSN:0003-3022    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

Binding of thiopental to proteins in plasma from healthy, cirrhotic, and uremic subjects was studied using equilibrium dialysis. In plasma from healthy volunteers 28.0 ± 0.9 per cent of thiopental was unbound. In plasma from patients with hepatic disease 53.0 ± 2.1 per cent was unbound, while in patients with renal disease 53.7 ± 1.5 per cent Method remained unbound. The decreased binding in uremia could not be explained completely by competitive displacement by nitrogenous end products or by hypoalbuminemia, although hypoalbuminemia may account for the decreased binding in cirrhotic patients.

ISSN:0003-3022    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

The cardiovascular effects of acute metabolic alkalosis (NaHCO3) in normal male volunteers anesthetized with halothane were measured. Pure metabolic alkalosis was studied by maintaining the end-tidal carbon dioxide tension at 40 torr. In each subject, cardiac index increased and total peripheral resistance decreased after each dose of NaHCO3. The increased cardiac index was associated with increased central blood volume, left ventricular minute work index, stroke index, and heart rate. Systolic time intervals showed in-creased myocardial performance. NaHCO3administered to volunteers whose hearts were depressed by halothane appeared to cause peripheral vasodilation, volume expansion, and myocardial stimulation. The authors conclude that NaHCO3, administered during halothane anesthesia decreases total peripheral resistance and may lead to severe hypotension.

ISSN:0003-3022    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

The effects of doxapram on carotid chemoreceptor activity and on ventilation (phrenic-nerve activity) were tested before and after denervation of the peripheral chemoreceptors in cats. Doxapram was found to be a potent stimulus to the carotid chemoreceptors; the stimulation produced by 1.0 mg/kg doxapram, iv, equalled that produced by a Pao2of 38 torr. Doxapram also increased phrenic-nerve activity in doses as low as 0.2 mg/kg, iv. After denervation of the peripheral chemoreceptors, doxapram in doses as large as 6 mg/kg failed to stimulate ventilation. It is concluded that (in anesthetized cats) doxapram in doses of less than 6 mg/kg increases ventilation by direct stimulation of the carotid, and, probably, the aortic, chemoreceptors, not by a direct effect on the medullary respiratory center.

ISSN:0003-3022    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

The hemodynamic response to the combination of isoflurane (1 MAC) and propranolol (0.5 mg/kg) was studied in 12 intact ventilated dogs following basal anesthesia with chloralose-urethane. When propranolol was administered during isoflurane anesthesia, stroke volume was maintained with a higher pulmonary capillary wedge pressure (3.2 ± 0.7 mm Hg to 6.3 ± 1.4 mm Hg), while systemic vascular resistance remained unchanged. When isoflurane was administered to the previously beta-adrenergically blocked dog, there were declines in systemic pressure and cardiac output (P < 0.01) and in pulmonary arterial pressure and stroke volume (P < 0.05), without change in systemic vascular resistance. When isoflurane was subsequently discontinued, these changes were reversed, and in addition, systemic vascular resistance increased (P < 0.05). These data indicate that isoflurane has pharmacologic properties compatible with a peripheral beta-adrenergic stimulating action.

ISSN:0003-3022    

出版商:OVID    

年代:1975

数据来源: OVID