ISSN:0003-3022    

出版商:OVID    

年代:1972

数据来源: OVID

摘要:

Mice died 5 to 24 hours after having recovered from anesthesia with 4.5 per cent fluroxene in air. Mortality was related to duration of anesthesia. No mortality was observed after halothane anesthesia. Pretreatment with phenobarbital increased mortality after fluroxene anesthesia, while pretreatment with carbon tetrachloride decreased mortality. This suggests that the toxic substance is not fluroxene itself but a metabolite, possibly trifluoroethanol.

ISSN:0003-3022    

出版商:OVID    

年代:1972

数据来源: OVID

摘要:

The effects of four inhalation anesthetics on rat-liver microsomal glucuronyltransferasc activity-have been examined in vitro. Anesthetics depressed tilts reaction in a dose-related, noncompetitive manner. Equal MAC values inhibited in a quantitatively similar manner. Formation of the glucuronic acid donor, UDPCA (uridine diplios-phoglucuronic acid) was depressed by only one of the anesthetics studied, diethyl ether.

ISSN:0003-3022    

出版商:OVID    

年代:1972

数据来源: OVID

ISSN:0003-3022    

出版商:OVID    

年代:1972

数据来源: OVID

摘要:

Suspension cultures of rat hepatoma cells growing logarithmically were exposed to 0.1–5.0 per cent halothane for 24 hours. Halothane inhibitedcell multiplication in a dose-related manner. This effect was completely reversible for all doses tested upon removal of halothane from the cultures. Highly significant inhibition of growth was detected within six hours. Cell viability was unaffected. High, but nontoxic, concentrations of acetate, pyruvate, and lactate did not prevent halothanc-induccd inhibition of cell multiplication.

ISSN:0003-3022    

出版商:OVID    

年代:1972

数据来源: OVID

摘要:

Using a large intravenous bolus of lidocaine and immediate and frequent sampling of arterial blood, the authors identified an initial rapidly-clearing lidocaine compartment in the cat. This first compartment has the volume characteristics of the cat's intravascular space. The three-compartment open model matches lidocaine kinetics better than the two-compartment model.

ISSN:0003-3022    

出版商:OVID    

年代:1972

数据来源: OVID

ISSN:0003-3022    

出版商:OVID    

年代:1972

数据来源: OVID

摘要:

Respiratory rate and peak airway pressure were independently varied during controlled mechanical ventilation of infants with severe respiratory distress syndrome. During the first five days of mechanical ventilation five newborn infants were studied four times each. Each study consisted of six predetermined rate and/or pressure changes. Pressures ranged from 21 to 53 cm H2O and rates from 8 to 40 breaths/min. Changes in Pao2, Paco2and pH2the dependent variables, were correlated with changes in the independent van-ablcs, rate and pressure. When pressure is increased, Pao2and pII2, increase and Paco2decreases. When rate is increased, Pao2and Paco2decrease and pH2, increases. The magnitudes of the changes in dependent variables for unit changes in rate and pressure are given. Specific variations of rate and/or pressure during controlled mechanical ventilation of infants with respiratory distress syndrome do result in changes in Pao2Paco2and pH2, which are predictable in magnitude and direction.

ISSN:0003-3022    

出版商:OVID    

年代:1972

数据来源: OVID

摘要:

The durations of neuromuscular blockades with various doses ofd-tubocurarine (dTc), gallamine, and pancuronium, without and with neostigmine reversal, were determined in 60 unpremedicated surgical patients anesthetized with nitrous oxide– halothane. Neostigmine, 0.25 mg, was administered intravenously every 3 minutes, beginning when twitch height showed 5 per cent recovery of the control twitch height. During spontaneous recovery from relaxant effects, times to achieve twitch heights which were 3 per cent of control twitch heights increased equally fordTc, gallamine, and pancuronium to doses of 12, 80, and 2.4 mg/m2, respectively. However, with gallamine, 120 mg/m2 this time was 80 to 100 per cent longer than withdTc, 18 mg/m2, or pancuronium, 3.6 mg/m2. Significantly more neostigmine (30 to 50 per cent) was needed to antagonize blockades produced by gallamine. These results suggest that the mechanism of action of gallamine may differ from those ofdTc and pancuronium.

ISSN:0003-3022    

出版商:OVID    

年代:1972

数据来源: OVID

摘要:

The effects of halothane and hypocapnia on cerebrospinal fluid pressure (CSFP) were ex amincd in 48 patients undergoing craniotomy for tumors (36 patients) or vascular lesions (12 patients). All patients were hyperventilated to Paco2levels less than 30 mm IIg (mean 26). Twenty-one patients (Group I) received halothane (0.5 to 1.0 per cent) simultaneously with the onset of hyperventilation, and 17 patients (Group II) received halothane (0.5 to 1.0 percent) after hyperventilation had been established for 10 minutes. Large increases in CSFP occurred only in Group I (seven patients, mean increase = 260 mm H2O). Only small increases in CSFP occurred in Group II (10 patients, mean increase = 26 mm H2O). The pressure increases in all patients were transient (10 to 30 minutes). A third group (10 patients) was given Innovar in the absence of halothane, and no increases in CSFP occurred. The authors conclude that halothane is capable of increasing CSFP in patients with intracranial disease, but that these increases are transient and can be minimized or abolished by the prior induction of hypocapnia.

ISSN:0003-3022    

出版商:OVID    

年代:1972

数据来源: OVID