ISSN:0003-3022    

出版商:OVID    

年代:1976

数据来源: OVID

ISSN:0003-3022    

出版商:OVID    

年代:1976

数据来源: OVID

ISSN:0003-3022    

出版商:OVID    

年代:1976

数据来源: OVID

摘要:

Halothane has dual effects on lipolysis of human adipose tissue: at low tissue concentrations a stimulatory effect is found, while at higher tissue concentrations lipolysis is inhibited. The lipolytic response of human adipose tissue was studiedin vitrowith or without halothane, the phosphodiesterase inhibitor theophylline, the lipase activator dibutyryl cAMP (dbcAMP), the α-receptor antagonist phentolamine, the nonselective β-receptor antagonist propranolol, and the selective β1-receptor antagonist practolol. In the absence of β-receptor antagonists low concentrations of halothane stimulated lipolysis. This effect was bhmted by β-receptor antagonists, indicating that halothane at low tissue concentrations may directly stimulate the β-receptors. The inhibitory effect of higher tissue concentrations of halothane was not the result of increased α-receptor activity since addition of phentolamine did not inhibit this effect High concentrations of theophylline or dbcAMP increased lipolysis in specimens exposed to halothane, but the lipolytic rate was still less than that found in specimens not exposed to halothane. The data thus indicate that the inhibitory effect of halothane is exerted at a step beyond the formation and degradation of cAMP.

ISSN:0003-3022    

出版商:OVID    

年代:1976

数据来源: OVID

ISSN:0003-3022    

出版商:OVID    

年代:1976

数据来源: OVID

摘要:

Ventilatory responses to CO2and hypoxia were measured in four normal volunteers breathing 30–50 per cent N2O with and without added inspiratory resistance. CO2response was measured by a steadystate technique, hypoxic response by a non-steadystate progressive technique. Added inspiratory resistance depressed ventilatory responses in both CO2and hypoxia. N2O had no effect on CO2response either with or without resistance. N2O depressed the ventilatory response to hypoxia without added resistance and further depressed the response measured with added resistance. It is thought that this was probably the result of selective depression of peripheral chemoceptor function by N2O.

ISSN:0003-3022    

出版商:OVID    

年代:1976

数据来源: OVID

摘要:

Carotid endarterectomy requires temporary surgical occlusion of the involved carotid artery. During occlusion, the minimally acceptable (critical) internal carotid artery stump pressure is reported to be 50 torr, whereas for regional cerebral blood flow (rCBF), a critical range is reported to be 18–24 ml/100 g/min. During 90 carotid endarterectomies. rCBF and stump pressure were measured and the EEG continuously monitored. A positive correlation between rCBF and stump pressure (i.e., when both were either above or below their respective critical values) was observed in only 58 percent of the cases. In 28 per cent stump pressures of less than 50 torr were observed despite rCBF's above 24 ml/100 g/min and normal EEG's. In 8 per cent stump pressures were more than 50 torr but rCBF's were less than 18 ml/100 g/min and EEG changes of ischemia were commonly observed. In the remaining 6 per cent rCBF's were marginal (18–24 ml/100 g/min) while stump pressures were more than 50 torr and EEG changes were not observed. The relationship between stump pressure and rCBF was influenced by the anesthetic. In the absence of transient ischemia during occlusion (that is, rCBF > 18 ml/100 g/min), halothane and enflurane anesthesia were associated with significantly higher rCBF's and lower stump pressures than was neuroleptanesthesia. Pre-occlusion and post-occlusion rCBF measurements also demonstrated cerebral vasodilation by halothane and enflurane (halothane > enflurane) and vasoconstriction by neuroleptanesthesia. It is concluded that stump pressure is an unreliable index of CBF during carotid occlusion and that its relationship to CBF is considerably influenced by the anesthetic.

ISSN:0003-3022    

出版商:OVID    

年代:1976

数据来源: OVID

摘要:

The neurobehavioral status of 20 newborn infants was evaluated after two to four hours of life following maternal epidural anesthesia with hupivacaine for labor and vaginal delivery. All infants were normal products of uncomplicated full-term gestations. The 20 infants, whose mothers had received continuous lumbar epidural anesthesia with bupivacaine. demonstrated no measurable difference from control infants and did not have the decrease in muscle tone and strength observed in infants whose mothers had received continous lumbar epidural anesthesia with lidocaine or mepivacaine in a previous study.

ISSN:0003-3022    

出版商:OVID    

年代:1976

数据来源: OVID

ISSN:0003-3022    

出版商:OVID    

年代:1976

数据来源: OVID

摘要:

In man, diazepam alone and in combination with scopolamine interferes with the memory of visual and painful stimuli. With a 15-minute interval between injection of the drug and the showing of emotionally neutral pictures, scopolamine (0.5 mg/70 kg) produces 14 per cent forgetting when evaluated 24 hours later. Under these conditions diazepam (10 mg/70 kg) produces 41 per cent forgetting, while the combination causes 64 per cent. Under conditions designed to insure selection of subjects in whom registration was clearly quite intact at the time of the initial exposure to the pictures, memory was still found to be impaired when tested 24 hours later. Graded doses of diazepam to as much as mg/70 kg in combination with 0.5 mg/70 kg scopolamine produced a virtually linear dose-response curve for amnesia. These results are compatible with the interpretation that the diazepam-scopolamine mixture interferes with memory by blocking consolidation of the memory trace.

ISSN:0003-3022    

出版商:OVID    

年代:1976

数据来源: OVID