ISSN:0003-3022    

出版商:OVID    

年代:1971

数据来源: OVID

ISSN:0003-3022    

出版商:OVID    

年代:1971

数据来源: OVID

摘要:

Halothane depresses the metabolism of amobarbital, hexobarbital, pentobarbital, and aminopyrine (type I substrates) by rat hepatic microsomal enzymes. This inhibition is dose-dependent, reversible, noncompetilive, and independent of the lipid solubilities of the substrates. In contrast, the metabolism of aniline (type II substrate) is enhanced by halothane. These actions may represent an effect of halothane on the terminal oxidase of the system, cytochrome P-450.

ISSN:0003-3022    

出版商:OVID    

年代:1971

数据来源: OVID

摘要:

Serun inorganic fluoride concentration and urinary inorganic fluoride and oxalic acid excretion were found to be markedly elevated in ten patients previously shown to have methoxyflurane-induced renal dysfunction. Five patients with climically evident renal dysfunction had a mean peak serum inorganic fluoride level (190.4 ± 20.9 μ/1) significantly higher (P< 0.02) than that of those with abnormalities in laboratory tests only (105.8 ± 17.0 μ/1). Similarly, patients with clinically evident renal dysfunction had a mean peak oxalic acid excretion (286.8 ± 39.3 mg/24 hours) significantly greater (P< 0.05) than that of those with laboratory abnormalities only (130.6 ± 51.4 mg/24 hours). That patients anesthetized with halothane had insignificant changes in serum inorganic fluoride concentration and oxalic acid excretion indicates that these substances are products of methoxyflurane metabolism. A proposed metabolic pathway to support this hypothesis is presented, as well as evidence to suggest that inorganic fluoride is the substance responsible for methoxyflurane; induced renal dysfunction.

ISSN:0003-3022    

出版商:OVID    

年代:1971

数据来源: OVID

摘要:

Liver mitochondria obtained from rats exposed to either 3 per cent or 5 per cent halothane had significantly higher rates of oxygen uptake than did those of a corresponding control series. This increased respiration occurred both in the presence and in the absence of adenosine diphosphate. No significant change in rates of respiration was found with exposure to 1 per cent halothane. The respiratory control ratio and adenosine-diphosphate-to-oxygen values were not altered by prior halothane anesthesia at any dose level used. Electron microscopic study of the mitochondria of the control and experimental groups revealed no morphologie differences. Apparently, therefore, the inhalation of halothane, as administered under the conditions of this study, does not induce any long-lasting impairment of liver mitochondrial function.

ISSN:0003-3022    

出版商:OVID    

年代:1971

数据来源: OVID

摘要:

The ability of isolated rat liver milochondria to accumulate calcium in the presence of various concentrations of halothane was studied. Calcium transport into mitochondria is completely prevented by true uncouplers of oxidative phosphorylation. Mitochondrial calcium accumulation continued in the presence of halothane concentratoins as high as 4 per cent. The rate of calcium accumulation showed as halothane levels increased, but the amount accumulated was the same. The conclusion is that halothane is not a true uncoupler of oxidative phosphorylation, and that any uncoupling with anesthetic levels must be very limited. Malignant hyperpyrexia associated with halothane anesthesia is probably not the result of a direct uncoupling of oxidative phosphorylation in normal mitochondria. Greater susceptibility of mitochondria in individuals prone to hyperpyrexia reactions for genetic reasons is not ruled out.

ISSN:0003-3022    

出版商:OVID    

年代:1971

数据来源: OVID

摘要:

The biotransformation of Ēthrane was studied in seven healthy female patients by measuring urinary fluorine excretion. The total amount of Ēthrane recovered was 85.1 per cent of the amount absorbed; 82.7 ± 18.8 per cent was recovered as unchanged Ēthrane in exhaled air and 2.4 per cent as nonvolatile fluorinated metabolites in urine. Of the urinary fluorine, 0.5 per cent was excreted in inorganic form and 1.9 per cent in organic form. Following anesthesia, urinary excretion rates of fluoride in reached a maximum in seven hours. Maximum excretion of organic fluorine metabolites was reached on the second day. Urinary excretion then assumed a simple exponential decay, with half-times of 1.53 days for inorganic fluoride and 3.69 days for or-ganic fluorine. The excretion of unaltered Ēthrane in exhaled air assumed a three-term exponential decay, with half-times of 17.8 minutes, 3.2 hours, and 36.2 hours.

ISSN:0003-3022    

出版商:OVID    

年代:1971

数据来源: OVID

摘要:

Mammalian hepatoma cells in suspension culture were exposed to thiopental, methohexital, amobarbital, and lidocaine in doses that reversibly inhibit cell multiplication. The effects of these drugs on the incorporation of exogenously administered macromolecular precursors (thymidine, uridine, and leueine) into their respective mac-romolecules (deoxyribonuleic acid, ribonucleic acid, and protein) were determined. All of these anesthetics produced nontelective, dose-related inhibition of precursor incorporation into the acid-insoluble cell fraction. This parallels their inhibitory effect on the rate of cell multiplication. The methodology used does not permit a more precise localization of the block in the incorporation processes.

ISSN:0003-3022    

出版商:OVID    

年代:1971

数据来源: OVID

ISSN:0003-3022    

出版商:OVID    

年代:1971

数据来源: OVID

摘要:

The cardiovascular effects of nitrous oxide-halo-thane-oxygen anesthesia were studied in eight unpremedicated healthy male volunteers and the results compared with those obtained in previous studies in which only halothane-oxygen anesthesia was used. Adding nitrous oxide to halothane-oxygen anesthesia resulted in less depression of the cardiovascular system than comparable levels of halothane-oxygen anesthesia. The differences were greatest at light levels of anesthesia and early in the anesthetic course. Most of the differences between the nitrous oxide and non-nitrous oxide groups were abolished at deeper levels of halothane anesthesia or after five hours of anesthesia had elapsed. Body temperature increased an average of 0.3 C with increasing depth of halothane anesthesia when nitrous oxide was present. The effect of discontinuing nitrous oxide for 15 minutes was also compared with data from a previous study in which nitrous oxide was added to halothane-oxygen anesthesia. The results seem to conform a sympathetic stimulating action of nitrous oxide.

ISSN:0003-3022    

出版商:OVID    

年代:1971

数据来源: OVID