ISSN:0003-3022    

出版商:OVID    

年代:1964

数据来源: OVID

ISSN:0003-3022    

出版商:OVID    

年代:1964

数据来源: OVID

摘要:

Alterations in physiological dead space have been calculated in 7 patients undergoing surgical procedures and subjected to nitrous oxide-halo-thane anesthesia with deliberate hypotension produced by pentolinium and head-up tilt. Mean blood pressure was lowered from an average of 87 mm. of mercury to an average of 50 mm. of mercury. Physiological dead space increased in all patients. The increase resulted from enlargement of both anatomical and alveolar dead spaces, but more especially the latter. The increase was greater in this group of patients as compared with another group anesthetized with the same agents but whose blood pressure was within normal limits.

ISSN:0003-3022    

出版商:OVID    

年代:1964

数据来源: OVID

摘要:

Using a physiological preparation in the dog to perfuse the subarachnoid space continuously, the amount of procaine recovered in the spinal fluid was determined after repeated epidural injections of various concentrations (0.5–5%). The studies extended into the post-mortem phase. The subarachnoid transfer of procaine was found to bear a direct relation to concentration. Repeated doses magnified the clinical effect of the previous injections and increased the amount of procaine recovered. This seemed to be due to incomplete vascular removal of the previous dose. Position influenced epidural clearance by allowing a greater paravertebral escape, possibly because of regional differences in circulation. A greater quantity of procaine was recovered from the sub-arachnoid space in the supine than in the lateral position. Death of the animal did not reduce subarachnoid passage. On the contrary, it prolonged the period of time during which procaine could be recovered.In correlating these facts with clinical experiences, we suggest that epidural blockade results from a dual mechanism, basically an intradural block, due to direct passage of the anesthetic through the dura, and secondly via an extradural absorption in the paravertebral regions.

ISSN:0003-3022    

出版商:OVID    

年代:1964

数据来源: OVID

摘要:

Contemporary methods of searching the literature have become obsolete. A technique has been developed of high speed literature search which provides instantly readable abstracts and full reference information on parent publications.

ISSN:0003-3022    

出版商:OVID    

年代:1964

数据来源: OVID

摘要:

One hundred patients for elective surgical procedures were given tetracaine spinal anesthesia and observations were made in regard to time of injection, onset of motor blockade and limb position before and after blockade. Twenty-four patients experienced a painless phantom sensation which was directly related to the position of their limbs at the time of the motor blockade. Seventy-three patients were supine with outstretched limbs at the time of onset of motor blockade and did not experience phantoms. Three patients had subarachnoid sacral block, did not lose proprioceptive function and did not have phantom sensations.

ISSN:0003-3022    

出版商:OVID    

年代:1964

数据来源: OVID

摘要:

Blood levels were correlated with clinical observations following the intravenous administration of 4-hydroxybutyrate in the unpremedicated patient. The blood level rose rapidly immediately following injection and then fell in a biphasic fashion. The peak clinical effect lagged behind the peak blood levels suggesting activity by means of a metabolite rather than the parent compound.There is evidence to suggest that the intercurrent administration of thiobarbiturate produces a rise in the blood level of 4-hydroxybutyrate.

ISSN:0003-3022    

出版商:OVID    

年代:1964

数据来源: OVID

摘要:

Studies were conducted to characterize electroanesthesia in cats and to provide insight into inter-relations of various electrical parameters. Data were obtained from 138 trials in 20 cats with a pair of subcutaneously implanted palladium wire electrodes, one located between the eyes and the other at the occiput. Current was provided by an instrument which delivered square-wave pulses automatically elevated above the zero potential base-line, which could be adjusted to various pulse durations and periods. Satisfactory anesthesia could be produced in cats without supplemental drugs or artificial ventilation. Assessment of pain reflexes during electro-anesthesia led to the suggestion that electrical current produces analgesia in ways not yet elucidated. Elevation of the electrical waveform above the base-line was not beneficial. Several residual effects were noted to persist for a short time after electro-anesthesia. The results also disclosed the importance of the relationhip of the waveforms' pulse duration and period. Waveforms with small ratios were the most effective in terms of achieving anesthesia with the least amount of average current.

ISSN:0003-3022    

出版商:OVID    

年代:1964

数据来源: OVID

摘要:

The effects of hyperventilation and of carbon dioxide inhalation on neuromuscular transmission, integrated electromyographic (IEMG) activity and on the action of d-tubocurarine were studied in patients during anesthesia and operation. The twitch response of the adductor pollicis muscle to supramaximal ulnar nerve stimulation was increased by hyperventilation and decreased by breathing 10 per cent CO2. The neuromuscular blocking action of d-tubocurarine was decreased by hyperventilation and increased by 10 per cent CO2. Both sets of results were attributed to induced changes in arterialpH and PCO2. The IEMG activity of the oblique-transversus group of abdominal muscles was not affected by inhalation of 10 per cent CO2but was decreased by hyperventilation. This latter effect, which was not due to hypocapnia but appeared to be reflex in nature, may be responsible for the clinically observed abdominal muscle relaxation seen with hyperventilation.

ISSN:0003-3022    

出版商:OVID    

年代:1964

数据来源: OVID

摘要:

A trace of C14-dimethyl-d-tubocurarine was administered intravenously to 26 control dogs and to 26 dogs under induced conditions of prolonged hypoxia, hypercapnia, shock and hypothermia. Fifteen hours subsequent to administration to the controls 0.8 per cent of the drug was still in plasma, 85 per cent was eliminated in the urine and 14 per cent was distributed in the extravascular space.Radiochromatographic scannings suggested that C14-dlimethyl-d-tubocurarine remains unchanged in the body of the dog. Seventy per cent of the C14-dimethyl-d-tuhocurarine was bound to human plasmain vitro.—After trace injection, a moderate amount of labeled curarine (of the order of 10-5of the administered dose) crossed the blood-brain barrier and appeared in cerebrospinal fluid. During the abnormal conditions a slower disappearance from plasma, impaired urinary elimination, higher and persistent accumulation in the extravascular space and increased passage into the CSF were found.

ISSN:0003-3022    

出版商:OVID    

年代:1964

数据来源: OVID