ISSN:0003-3022    

出版商:OVID    

年代:1970

数据来源: OVID

ISSN:0003-3022    

出版商:OVID    

年代:1970

数据来源: OVID

ISSN:0003-3022    

出版商:OVID    

年代:1970

数据来源: OVID

摘要:

Plasma levels of bupivacaine following peridural administration of 150 mg bupivacaine hydrochloride with epinephrine to 12 patients, 150 mg without epinephrine to five patients, and 225 mg with epinephrine to six patients were determined. Cerebrospinal fluid levels in five of the patients in the first group were also studied. Peak plasma levels were attained in 20 min in all of the above groups. These levels were 1.14, 1.26 and 2.33 μg/ml, respectively. The peak CSF level, 30.6 μg/ml, was observed 30 min after administration. These levels are generally comparable to those that might be expected after administration of equivalent doses of the more established local anesthetics. The post-absorption/distribution half-life of bupivacaine in both plasma and CSF ranged from 2.4 to 3.6 hours, which is not significantly different from the half-lives of shorter-acting drugs such as lidocaine, prilocaine and mepivacaine. It is concluded that the relatively long duration of action of bupivacaine is related not to its overall retention in the body but rather to its binding to nerve tissue.

ISSN:0003-3022    

出版商:OVID    

年代:1970

数据来源: OVID

摘要:

The effects of 0.75 to 2 per cent end-tidal halothane on cardiovascular and respiratory responses to hypoxia were quantitated. Moderate hypoxia (Pa02. 45 torr) caused stimulation of ventilation and cardiac output at all levels of halothane anesthesia. Although severe hypoxia (Pa0230 torr) further stimulated ventilation and cardiac output at 0.75 to 1.25 per cent halothane, increasing the halothane concentration to 1.0–1.5 per cent rapidly converted hyperventilation and elevated cardiac output to respiratory or cardiac arrest. Oxygen transport did not meet oxygen consumption requirements; hence, severe metabolic acidosis developed during severe hypoxia. Within narrow limits, the dose of halothane is most important in determining the physiologic response to severe hypoxia.

ISSN:0003-3022    

出版商:OVID    

年代:1970

数据来源: OVID

ISSN:0003-3022    

出版商:OVID    

年代:1970

数据来源: OVID

摘要:

The effect of cyclopropane anesthesia on the intrinsic state of the myocardium of the intact heart was determined by means of force-velocity relations in 14 dogs. The maximal intrinsic velocity (Vmax), an index of myocardial contractility, was obtained before and during anesthesia by extrapolating either the force-velocity curve using stress calculation or the isovolemic force-velocity curve using the simplified formula of (dP/dt)/kp as the contractile element velocity. Cyclopropane (arterial blood concentration ranging from 9 to 46 mg/100 ml) did not cause any significant change in either shape or position of the force-velocity curves. The average change in Vmaxwas −6 per cent (P> 0.2). These findings indicate that cyclopropane anesthesia does not alter myocardial contractility.

ISSN:0003-3022    

出版商:OVID    

年代:1970

数据来源: OVID

ISSN:0003-3022    

出版商:OVID    

年代:1970

数据来源: OVID

摘要:

Sixty patients anesthetized with halothane were given either succinylcholine alone or succinylcholine after hexafluorenium. The authors determined the degree of prolongation of relaxation induced by hexafluorenium, as well as the rapidity of recovery following multiple injections of the combination of drugs. Neuromuscular block was evaluated by recording muscle twitch tension response to nerve stimulation. The duration of action of a single dose of succinylcholine, 0.2 mg/kg, was increased sixfold to eightfold when preceded by hexafluorenium, 0.4 mg/kg. After multiple doses of the two drugs, rapidity of recovery from the final dose of succinylcholine was dependent upon the period of time over which the drugs had been administered. Four of 20 patients so treated did not recover for nearly an hour. Since the purported advantage of using hexafluorenium with succinylcholine is to avoid the delayed recovery sometimes seen when succinylcholine is used alone, the authors question the continued use of this technique.

ISSN:0003-3022    

出版商:OVID    

年代:1970

数据来源: OVID

ISSN:0003-3022    

出版商:OVID    

年代:1970

数据来源: OVID